Preparation and in-vitro evaluation of a biodegradable carrier system for inducing spawning in fish

Jen S. Wu, Chian J. Huang, Chen Chun Ku, Tsuimin Tsai

Research output: Contribution to journalArticle


Repeated injections of hormone drugs to fish reared in captivity during the spawning season is a routine procedure for local fishermen in Taiwan. To prevent stress resulting from multiple administrations, we developed a delivery system using poly(D,L-lactide-co-glycolide) (PLGA) as a carrier. Two drugs, human chorionic gonadotropin (HCG) and leutenizing hormone-releasing hormone Analog-2 (LHRH-A2), which are commonly used by fishermen, were loaded into polymeric microbeads. The microbeads released more than 20% of the loaded drug in an initial burst. However, drug readsorbed to the carrier and 100% release was not achieved in the in vitro studies. For induction of spawning, burst release accompanied by subsequent slow release is a potential single injection administration system.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalChinese Pharmaceutical Journal
Issue number2
Publication statusPublished - Apr 1999



  • Biodegradable polymer
  • Drug delivery system
  • Human chorionic gonadotropin (HCG)
  • Leutenizing hormone-releasing hormone analog-2 (LHRH-A)
  • Poly(D,L-lactide-co-glycolide) (PLGA)

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

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