Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers

Shu Huei Yu, Fwu Long Mi, Jen Chieh Pang, Shun Chou Jiang, T. H. Kuo, Shao Jung Wu, Shing Shin Shyu

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS+ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.

Original languageEnglish
Pages (from-to)794-802
Number of pages9
JournalCarbohydrate Polymers
Volume84
Issue number2
DOIs
Publication statusPublished - Mar 1 2011
Externally publishedYes

Fingerprint

Gallic Acid
Drug Carriers
Chitosan
Acids
Iron
Nanoparticles
Carbodiimides
Scavenging
Antioxidants
Biological Products
Light scattering
O-carboxymethylchitosan
Fluorescence
Particle size
Nuclear magnetic resonance
Derivatives
Proteins
Water

Keywords

  • Chitosan
  • Gallic acid
  • PH-responsive
  • Radical scavenging

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers. / Yu, Shu Huei; Mi, Fwu Long; Pang, Jen Chieh; Jiang, Shun Chou; Kuo, T. H.; Wu, Shao Jung; Shyu, Shing Shin.

In: Carbohydrate Polymers, Vol. 84, No. 2, 01.03.2011, p. 794-802.

Research output: Contribution to journalArticle

Yu, Shu Huei ; Mi, Fwu Long ; Pang, Jen Chieh ; Jiang, Shun Chou ; Kuo, T. H. ; Wu, Shao Jung ; Shyu, Shing Shin. / Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers. In: Carbohydrate Polymers. 2011 ; Vol. 84, No. 2. pp. 794-802.
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