Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers

Shu Huei Yu, Fwu Long Mi, Jen Chieh Pang, Shun Chou Jiang, T. H. Kuo, Shao Jung Wu, Shing Shin Shyu

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS+ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.

Original languageEnglish
Pages (from-to)794-802
Number of pages9
JournalCarbohydrate Polymers
Volume84
Issue number2
DOIs
Publication statusPublished - Mar 1 2011
Externally publishedYes

Keywords

  • Chitosan
  • Gallic acid
  • PH-responsive
  • Radical scavenging

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Fingerprint Dive into the research topics of 'Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers'. Together they form a unique fingerprint.

Cite this