Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers

Shu Huei Yu; Fwu Long Mi; Jen Chieh Pang; Shun Chou Jiang; Tzu Hung Kuo; Shao Jung Wu; Shing Shin Shyu

doi:10.1016/j.carbpol.2010.04.035

Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers

Shu Huei Yu, Fwu Long Mi, Jen Chieh Pang, Shun Chou Jiang, Tzu Hung Kuo, Shao Jung Wu, Shing Shin Shyu

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS⁺ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.

Original language	English
Pages (from-to)	794-802
Number of pages	9
Journal	Carbohydrate Polymers
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/j.carbpol.2010.04.035
Publication status	Published - Mar 1 2011
Externally published	Yes

Keywords

Chitosan
Gallic acid
PH-responsive
Radical scavenging

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2010.04.035

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title = "Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers",

abstract = "A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS+ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.",

keywords = "Chitosan, Gallic acid, PH-responsive, Radical scavenging",

author = "Yu, {Shu Huei} and Mi, {Fwu Long} and Pang, {Jen Chieh} and Jiang, {Shun Chou} and Kuo, {Tzu Hung} and Wu, {Shao Jung} and Shyu, {Shing Shin}",

note = "Funding Information: The financial support for this research was provided by the National Science Council (NSC 97-2221-E-238-002-MY2 ), Taiwan, ROC.",

year = "2011",

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doi = "10.1016/j.carbpol.2010.04.035",

language = "English",

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AU - Yu, Shu Huei

AU - Mi, Fwu Long

AU - Pang, Jen Chieh

AU - Jiang, Shun Chou

AU - Kuo, Tzu Hung

AU - Wu, Shao Jung

AU - Shyu, Shing Shin

N1 - Funding Information: The financial support for this research was provided by the National Science Council (NSC 97-2221-E-238-002-MY2 ), Taiwan, ROC.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS+ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.

AB - A novel chitosan-based nanoparticle carrier was prepared in this study. The chitosan derivative, N,O-carboxymethylchitosan (NOCC) was reacted with gallic acid (GA) using a non-toxic water-soluble carbodiimide to obtain the NOCC-GA conjugate, and the chemical structure of the conjugate was characterized with FT-IR and NMR spectra. The antioxidant activity of the NOCC-GA conjugate was examined by DPPH and ABTS+ radical scavenging activity. The radical/pH-responsive properties of the NOCC-GA conjugate and its iron(II) complex were examined by fluorescence spectral and light transmittance studies. The mean particle sizes of the NOCC-GA conjugate and its iron(II) complex nanoparticles were determined by a light scattering method. The NOCC-GA conjugate and its iron(II) complex nanoparticles might provide a novel way to deliver antioxidative protein or natural products in future.

KW - Chitosan

KW - Gallic acid

KW - PH-responsive

KW - Radical scavenging

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Preparation and characterization of radical and pH-responsive chitosan-gallic acid conjugate drug carriers

Abstract

Keywords

ASJC Scopus subject areas

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