Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin.

Jun Jen Liu, Sami Nazzal, Tzu Shan Chang, Tsuimin Tsai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The objective of this study was to develop and characterize a liposome delivery system coencapsulating two cosmeceutical ingredients, avobenzone (AVO) and arbutin (AR). Two different liposome preparation methods, that is, thin film hydration and reverse-phase evaporation, were evaluated. To obtain the optimal formulation, various ratios of lipid to AVO or AR were tested. The effects of liposome formulation and preparation method on particle size, entrapment efficiency (EE), and skin permeation rate were studied. The mean particle size of the liposome formulations obtained by the thin film hydration method was smaller than that obtained by the reverse-phase evaporation method. The EE of AR and AVO in liposomes prepared by the thin film method, however, was lower than that prepared by the reverse-phase evaporation method. No differences in membrane permeation were observed between the two preparation methods. A large portion of AR permeated through the membrane into the receptor chamber. On the other hand, AVO remained in the donor chamber or accumulated in the membrane. The results of this study revealed that liposomes are a promising delivery system for coencapsulated AR and AVO. Liposomes may aid in retaining the sunscreen (AVO) at the surface of the skin for sun protection meanwhile facilitating the penetration of the whitening agent (AR) into the deeper layers of the skin for whitening effect.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalJournal of Cosmetic Science
Volume64
Issue number1
Publication statusPublished - Jan 2013

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Arbutin
Liposomes
Skin
Evaporation
Membranes
Particle Size
Permeation
Thin films
Hydration
Particle size
Bleaching Agents
Sun hoods
Sunscreening Agents
Solar System
avobenzone
Cosmeceuticals
Sun
Lipids

ASJC Scopus subject areas

  • Chemistry(all)
  • Dermatology

Cite this

Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin. / Liu, Jun Jen; Nazzal, Sami; Chang, Tzu Shan; Tsai, Tsuimin.

In: Journal of Cosmetic Science, Vol. 64, No. 1, 01.2013, p. 9-17.

Research output: Contribution to journalArticle

Liu, Jun Jen ; Nazzal, Sami ; Chang, Tzu Shan ; Tsai, Tsuimin. / Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin. In: Journal of Cosmetic Science. 2013 ; Vol. 64, No. 1. pp. 9-17.
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