Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting

Tao Min Huang, Vin Cent Wu, Guang Huar Young, Yu Feng Lin, Chih Chung Shiao, Pei Chen Wu, Wen Yi Li, Hsi Yu Yu, Fu Chang Hu, Jou Wei Lin, Yih Sharng Chen, Yen Hung Lin, Shoei Shen Wang, Ron Bin Hsu, Fan Chi Chang, Nai Kuan Chou, Tzong Shinn Chu, Yu Chang Yeh, Pi Ru Tsai, Jenq Wen HuangShuei Liong Lin, Yung Ming Chen, Wen Je Ko, Kwan Dun Wu

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Whether preoperative proteinuria associates with adverse renal outcomes after cardiac surgery is unknown. Here, we performed a secondary analysis of a prospectively enrolled cohort of adult patients undergoing coronary artery bypass grafting (CABG) at a medical center and its two affiliate hospitals between 2003 and 2007. We excluded patients with stage 5 CKD or those who received dialysis previously. We defined proteinuria, measured with a dipstick, as mild (trace to 1+) or heavy (2+ to 4+). Among a total of 1052 patients, cardiac surgery-associated acute kidney injury (CSA-AKI) developed in 183 (17.4%) patients and required renal replacement therapy (RRT) in 50 (4.8%) patients. In a multiple logistic regression model, mild and heavy proteinuria each associated with an increased odds of CSA-AKI, independent of CKD stage and the presence of diabetes mellitus (mild: OR 1.66, 95% CI 1.09 to 2.52; heavy: OR 2.30, 95% CI 1.35 to 3.90). Heavy proteinuria also associated with increased odds of postoperative RRT (OR 7.29, 95% CI 3.00 to 17.73). In summary, these data suggest that preoperative proteinuria is a predictor of CSA-AKI among patients undergoing CABG.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalJournal of the American Society of Nephrology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

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Proteinuria
Coronary Artery Bypass
Kidney
Thoracic Surgery
Acute Kidney Injury
Renal Replacement Therapy
Logistic Models
Dialysis
Diabetes Mellitus

ASJC Scopus subject areas

  • Nephrology

Cite this

Huang, T. M., Wu, V. C., Young, G. H., Lin, Y. F., Shiao, C. C., Wu, P. C., ... Wu, K. D. (2011). Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting. Journal of the American Society of Nephrology, 22(1), 156-163. https://doi.org/10.1681/ASN.2010050553

Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting. / Huang, Tao Min; Wu, Vin Cent; Young, Guang Huar; Lin, Yu Feng; Shiao, Chih Chung; Wu, Pei Chen; Li, Wen Yi; Yu, Hsi Yu; Hu, Fu Chang; Lin, Jou Wei; Chen, Yih Sharng; Lin, Yen Hung; Wang, Shoei Shen; Hsu, Ron Bin; Chang, Fan Chi; Chou, Nai Kuan; Chu, Tzong Shinn; Yeh, Yu Chang; Tsai, Pi Ru; Huang, Jenq Wen; Lin, Shuei Liong; Chen, Yung Ming; Ko, Wen Je; Wu, Kwan Dun.

In: Journal of the American Society of Nephrology, Vol. 22, No. 1, 01.2011, p. 156-163.

Research output: Contribution to journalArticle

Huang, TM, Wu, VC, Young, GH, Lin, YF, Shiao, CC, Wu, PC, Li, WY, Yu, HY, Hu, FC, Lin, JW, Chen, YS, Lin, YH, Wang, SS, Hsu, RB, Chang, FC, Chou, NK, Chu, TS, Yeh, YC, Tsai, PR, Huang, JW, Lin, SL, Chen, YM, Ko, WJ & Wu, KD 2011, 'Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting', Journal of the American Society of Nephrology, vol. 22, no. 1, pp. 156-163. https://doi.org/10.1681/ASN.2010050553
Huang, Tao Min ; Wu, Vin Cent ; Young, Guang Huar ; Lin, Yu Feng ; Shiao, Chih Chung ; Wu, Pei Chen ; Li, Wen Yi ; Yu, Hsi Yu ; Hu, Fu Chang ; Lin, Jou Wei ; Chen, Yih Sharng ; Lin, Yen Hung ; Wang, Shoei Shen ; Hsu, Ron Bin ; Chang, Fan Chi ; Chou, Nai Kuan ; Chu, Tzong Shinn ; Yeh, Yu Chang ; Tsai, Pi Ru ; Huang, Jenq Wen ; Lin, Shuei Liong ; Chen, Yung Ming ; Ko, Wen Je ; Wu, Kwan Dun. / Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting. In: Journal of the American Society of Nephrology. 2011 ; Vol. 22, No. 1. pp. 156-163.
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AU - Wu, Vin Cent

AU - Young, Guang Huar

AU - Lin, Yu Feng

AU - Shiao, Chih Chung

AU - Wu, Pei Chen

AU - Li, Wen Yi

AU - Yu, Hsi Yu

AU - Hu, Fu Chang

AU - Lin, Jou Wei

AU - Chen, Yih Sharng

AU - Lin, Yen Hung

AU - Wang, Shoei Shen

AU - Hsu, Ron Bin

AU - Chang, Fan Chi

AU - Chou, Nai Kuan

AU - Chu, Tzong Shinn

AU - Yeh, Yu Chang

AU - Tsai, Pi Ru

AU - Huang, Jenq Wen

AU - Lin, Shuei Liong

AU - Chen, Yung Ming

AU - Ko, Wen Je

AU - Wu, Kwan Dun

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