Preoperative gabapentin prevents intrathecal morphine- induced pruritus after orthopedic surgery

Michael J. Sheen, Shung T. Ho, Chian H. Lee, Yu C. Tsung, Fang L. Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

BACKGROUND: Pruritus is the most common side effect of intrathecal morphine. Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. Its effect in intrathecal morphine-induced pruritus has not yet undergone an evaluation. METHODS: We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5% isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. RESULTS: The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5% vs 47.5%; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 ± 1.8 h) was significantly delayed compared with that in the placebo group (3.1 ± 0.8 h) (P <0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. CONCLUSION: Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia.

Original languageEnglish
Pages (from-to)1868-1872
Number of pages5
JournalAnesthesia and Analgesia
Volume106
Issue number6
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Fingerprint

Pruritus
Morphine
Orthopedics
Placebos
Spinal Injections
Spinal Anesthesia
Lower Extremity
gabapentin
Bupivacaine
Anticonvulsants
Incidence

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Preoperative gabapentin prevents intrathecal morphine- induced pruritus after orthopedic surgery. / Sheen, Michael J.; Ho, Shung T.; Lee, Chian H.; Tsung, Yu C.; Chang, Fang L.

In: Anesthesia and Analgesia, Vol. 106, No. 6, 06.2008, p. 1868-1872.

Research output: Contribution to journalArticle

Sheen, Michael J. ; Ho, Shung T. ; Lee, Chian H. ; Tsung, Yu C. ; Chang, Fang L. / Preoperative gabapentin prevents intrathecal morphine- induced pruritus after orthopedic surgery. In: Anesthesia and Analgesia. 2008 ; Vol. 106, No. 6. pp. 1868-1872.
@article{c1173e15b9f740298d6c266914ef75b3,
title = "Preoperative gabapentin prevents intrathecal morphine- induced pruritus after orthopedic surgery",
abstract = "BACKGROUND: Pruritus is the most common side effect of intrathecal morphine. Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. Its effect in intrathecal morphine-induced pruritus has not yet undergone an evaluation. METHODS: We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5{\%} isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. RESULTS: The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5{\%} vs 47.5{\%}; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 ± 1.8 h) was significantly delayed compared with that in the placebo group (3.1 ± 0.8 h) (P <0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. CONCLUSION: Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia.",
author = "Sheen, {Michael J.} and Ho, {Shung T.} and Lee, {Chian H.} and Tsung, {Yu C.} and Chang, {Fang L.}",
year = "2008",
month = "6",
doi = "10.1213/ane.0b013e3181730130",
language = "English",
volume = "106",
pages = "1868--1872",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Preoperative gabapentin prevents intrathecal morphine- induced pruritus after orthopedic surgery

AU - Sheen, Michael J.

AU - Ho, Shung T.

AU - Lee, Chian H.

AU - Tsung, Yu C.

AU - Chang, Fang L.

PY - 2008/6

Y1 - 2008/6

N2 - BACKGROUND: Pruritus is the most common side effect of intrathecal morphine. Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. Its effect in intrathecal morphine-induced pruritus has not yet undergone an evaluation. METHODS: We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5% isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. RESULTS: The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5% vs 47.5%; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 ± 1.8 h) was significantly delayed compared with that in the placebo group (3.1 ± 0.8 h) (P <0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. CONCLUSION: Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia.

AB - BACKGROUND: Pruritus is the most common side effect of intrathecal morphine. Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. Its effect in intrathecal morphine-induced pruritus has not yet undergone an evaluation. METHODS: We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5% isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. RESULTS: The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5% vs 47.5%; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 ± 1.8 h) was significantly delayed compared with that in the placebo group (3.1 ± 0.8 h) (P <0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. CONCLUSION: Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia.

UR - http://www.scopus.com/inward/record.url?scp=44649110828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44649110828&partnerID=8YFLogxK

U2 - 10.1213/ane.0b013e3181730130

DO - 10.1213/ane.0b013e3181730130

M3 - Article

C2 - 18499625

AN - SCOPUS:44649110828

VL - 106

SP - 1868

EP - 1872

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 6

ER -