Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring

Julia Yi Ru Chen, Geng Chang Yeh, Pao Luh Tao, Chun Ting Kuo, Kuen Bao Chen, Yeong-Ray Wen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Maternal methamphetamine (MA) abuse during pregnancy has been proved to induce various impacts on the development of infant and child. In this study, we examined whether prenatal exposure to MA would affect the development of nociceptive system by measuring the responses to noxious stimulation in the developing rat. Adult female Sprague-Dawley rats received bi-daily subcutaneous injection of methamphetamine (5 mg/kg) or isovolumetric normal saline since the day of mating till the day of delivery. Birth profiles of the offspring including birth length, weight, and body temperature were recorded during the first postnatal month. Mechanical withdrawal thresholds were measured by von Frey filaments on postnatal day (PND) 30 and 60, and hyperalgesic behaviors following plantar formalin injection (2%, 50. μl) were evaluated on PND 60. The birth body weight and length of rats born to MA-injected dam rats (MA group) were significantly lower than those of the control rats during the first postnatal month; however, their body temperature was significantly higher than those of the control rats during the first 3 days after birth. The MA group rats had significantly lower tactile withdrawal values in von Frey test and higher pain scores in the late phase of pain in the formalin test than those of the control rats. There is a gender difference of nociceptive hypersensitivity manifested as that the female MA group rats had significantly lower withdrawal thresholds and higher pain scores in response to formalin injection than the male MA group rats. These results suggest that prenatal MA exposure could predispose an alteration in the development of nociceptive neuronal network, which leads to a long-lasting status of hypersensitivity to pain stimulations in the offspring.

Original languageEnglish
Pages (from-to)432-438
Number of pages7
JournalNeuroToxicology
Volume31
Issue number5
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Methamphetamine
Hyperalgesia
Rats
Rat control
Formaldehyde
Child Development
Body Temperature
Birth Weight
Pain
Hypersensitivity
Parturition
Injections
Pain Threshold
Touch
Pain Measurement
Subcutaneous Injections
Dams
Sprague Dawley Rats
Body Weight
Mothers

Keywords

  • Formalin
  • Methamphetamine
  • Nociception
  • Pain threshold
  • Prenatal exposure
  • Von Frey

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring. / Chen, Julia Yi Ru; Yeh, Geng Chang; Tao, Pao Luh; Kuo, Chun Ting; Chen, Kuen Bao; Wen, Yeong-Ray.

In: NeuroToxicology, Vol. 31, No. 5, 09.2010, p. 432-438.

Research output: Contribution to journalArticle

Chen, Julia Yi Ru ; Yeh, Geng Chang ; Tao, Pao Luh ; Kuo, Chun Ting ; Chen, Kuen Bao ; Wen, Yeong-Ray. / Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring. In: NeuroToxicology. 2010 ; Vol. 31, No. 5. pp. 432-438.
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