Preliminary Results of Fractionated Stereotactic Radiotherapy in Patients with Advanced Hepatocellular Carcinoma

王 博民, 辛 政憲(Shin-Jeng Shiang), 鍾 娜娜, 丁 禮莉(Lai-Lei Ting), 雷 德, 林 高德

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The treatment result of advanced hepatocellular carcinoma failed from previous TACE is often unsatisfactory. To minimize the acute and late adverse effects of liver irradiation and preserve maximal normal liver tissue, fractionated stereotactic radiotherapy (R/T) is used in our institute.Materials & Methods: Twenty-three patients with advanced hepatocellular carcinoma received fractionated stereotactic radiotherapy with 55Gy in 22 fractions. All patients were assessable for side effects and response.Results: The mean regression of turner volume was 29% at 1 month after completion of R?T, 41% at 2 months and 55% at 3 months. In 17 patients with elevated serum alpha-fetoptein (AFP), 15 (88%) were found to have response in the first month after R/T, 10 (59%) had regression of more than 50% of the original level at the first month after R/T. Conclusion: For patients with advanced hepatocellular carcinoma, the fractionated stereotactic radiotherapy is a feasible modality and deserves further follow-up for outcome and toxicity.
Translated title of the contribution利用分次立體定位放射治療方式治療晚期肝細胞癌病人之初步成果
Original languageEnglish
Pages (from-to)247-252
Number of pages6
Journal放射治療與腫瘤學
Volume6
Issue number4
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Advanced hepatocellular carcinoma
  • Fractionated stereotactic radiotherapy
  • Radiation toxicity

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