Preliminary findings of serum creatinine and estimated glomerular filtration rate (eGFR) in adolescents with intellectual disabilities

Jin Ding Lin, Lan Ping Lin, Molly Hsieh, Pei Ying Lin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The present study aimed to describe the kidney function profile - serum creatinine and estimated glomerular filtration rate (eGFR), and to examine the relationships of predisposing factors to abnormal serum creatinine in people with intellectual disabilities (ID). Data were collected by a cross-sectional study of 827 aged 15-18 years adolescents with ID who participated in annual health examinations as they enrolled into special education schools in Taiwan. We used serum samples to determine participants' creatinine profiles, and the Cockcroft-Gault formula to calculate the data of eGFR to present the chronic kidney disease. The results found 22% of the participants have abnormal serum creatinine value (creatinine>1.0mg/dl) and 59.6%, 36.4% and 4.0% at chronic kidney disease (CKD) stage 1, 2 and 3 cases accordingly based on the Cockcroft-Gault formula. No CKD stage 4 and 5 cases in this study. That is, there were 4% CKD cases (eGFR <60mL/min/1.73m2; CKD stage 3, 4 and 5) in adolescents with ID in this study. The results also indicated that gender and BMI could significantly predict abnormal creatinine condition in multivariate logistic regression analysis. Those boys with ID were more likely to have abnormal creatinine value than girls with ID (OR=10.13, 95% CI=5.96-17.23). In term of BMI, those underweight adolescents with ID were less likely to have high creatinine value compared to normal weight group (OR=0.45, 95% CI=0.28-0.72). In summary, this study provides the preliminary information of creatinine and estimated GFR in people with ID; we suggest the public health policy should initiate appropriate management strategies to monitor kidney function and to improve treatment outcomes of chronic kidney disease for this vulnerable population.

Original languageEnglish
Pages (from-to)1390-1397
Number of pages8
JournalResearch in Developmental Disabilities
Volume31
Issue number6
DOIs
Publication statusPublished - Nov 1 2010
Externally publishedYes

Fingerprint

Glomerular Filtration Rate
Intellectual Disability
Creatinine
Chronic Renal Insufficiency
Serum
Disabled Persons
Kidney
Special Education
Thinness
Vulnerable Populations
Public Policy
Health Policy
Taiwan
Causality
Public Health
Cross-Sectional Studies
Logistic Models
Regression Analysis
Weights and Measures
Health

Keywords

  • Creatinine
  • Estimated glomerular filtration rate (eGFR)
  • Intellectual disability
  • The Cockcroft-Gault formula

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology

Cite this

Preliminary findings of serum creatinine and estimated glomerular filtration rate (eGFR) in adolescents with intellectual disabilities. / Lin, Jin Ding; Lin, Lan Ping; Hsieh, Molly; Lin, Pei Ying.

In: Research in Developmental Disabilities, Vol. 31, No. 6, 01.11.2010, p. 1390-1397.

Research output: Contribution to journalArticle

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abstract = "The present study aimed to describe the kidney function profile - serum creatinine and estimated glomerular filtration rate (eGFR), and to examine the relationships of predisposing factors to abnormal serum creatinine in people with intellectual disabilities (ID). Data were collected by a cross-sectional study of 827 aged 15-18 years adolescents with ID who participated in annual health examinations as they enrolled into special education schools in Taiwan. We used serum samples to determine participants' creatinine profiles, and the Cockcroft-Gault formula to calculate the data of eGFR to present the chronic kidney disease. The results found 22{\%} of the participants have abnormal serum creatinine value (creatinine>1.0mg/dl) and 59.6{\%}, 36.4{\%} and 4.0{\%} at chronic kidney disease (CKD) stage 1, 2 and 3 cases accordingly based on the Cockcroft-Gault formula. No CKD stage 4 and 5 cases in this study. That is, there were 4{\%} CKD cases (eGFR <60mL/min/1.73m2; CKD stage 3, 4 and 5) in adolescents with ID in this study. The results also indicated that gender and BMI could significantly predict abnormal creatinine condition in multivariate logistic regression analysis. Those boys with ID were more likely to have abnormal creatinine value than girls with ID (OR=10.13, 95{\%} CI=5.96-17.23). In term of BMI, those underweight adolescents with ID were less likely to have high creatinine value compared to normal weight group (OR=0.45, 95{\%} CI=0.28-0.72). In summary, this study provides the preliminary information of creatinine and estimated GFR in people with ID; we suggest the public health policy should initiate appropriate management strategies to monitor kidney function and to improve treatment outcomes of chronic kidney disease for this vulnerable population.",
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