Pregnancy following oocyte donation and tubal embryo transfer in patients with premature ovarian failure

report of two cases.

Y. S. Yang, J. L. Hwang, H. N. Ho, Y. S. Kuo, Y. R. Lien, T. Y. Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Two pregnancies in patients with premature ovarian failure utilizing donated oocytes, in-vitro fertilization (IVF) and tubal embryo transfer (TET), are reported. The recipients received cyclic hormone replacement therapy for six months to prepare the endometrium for implantation. An evaluation cycle was tested to document that the hormone milieu established by the hormone replacement protocol was similar to that of a natural ovulatory cycle. During the oocyte donation cycle, the recipient received incremental estrogen replacement treatment of flexible length during the follicular phase of the donor's stimulated cycle to synchronize the recipient's endometrium to the donor's embryo. Concurrently, the donor underwent controlled ovarian hyperstimulation and transvaginal ultrasound-guided oocyte retrieval. After fertilization of the donated oocytes with sperm from the recipient's husband and cleavage of the fertilized oocytes into the 2- to 4-cell stage, laparoscopic embryo transfer into the recipient's fallopian tube was performed. Case 1 received 4 embryos by the TET procedure. Pregnancy was confirmed by visualization of a gestational sac in the uterine cavity 3 weeks after TET, but miscarriage occurred at the tenth gestational week. In Case 2, the pregnancy was established after TET of 2 embryos. Estrogen and progesterone supplements were maintained until day 100 after TET. The patient delivered a healthy male baby, weighing 2,520 g at 38 weeks of gestation.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume90
Issue number7
Publication statusPublished - Jan 1 1991

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Oocyte Donation
Primary Ovarian Insufficiency
Embryo Transfer
Oocytes
Pregnancy
Embryonic Structures
Tissue Donors
Endometrium
Gestational Sac
Hormones
Oocyte Retrieval
Estrogen Replacement Therapy
Follicular Phase
Fallopian Tubes
Hormone Replacement Therapy
Spontaneous Abortion
Fertilization in Vitro
Spouses
Fertilization
Progesterone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pregnancy following oocyte donation and tubal embryo transfer in patients with premature ovarian failure : report of two cases. / Yang, Y. S.; Hwang, J. L.; Ho, H. N.; Kuo, Y. S.; Lien, Y. R.; Lee, T. Y.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 90, No. 7, 01.01.1991, p. 688-692.

Research output: Contribution to journalArticle

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