Pregnancy following in vitro fertilization and embryo transfer by Microsurgical Epididymal Sperm Aspiration from a patient with Congenital Absence of the Vas Deferens: A case report

Chii Rucy Tzeng, Sen Yuan Hsiao, Li Wei Chien, Shu Ru Chang, Han-Sun Chiang, Chien Chih Wu, An Chiun Chen

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1 Citation (Scopus)

Abstract

Congenital absence of the vas deferens (CAVD) has been considered a virtually untreatable cause of male infertility. Men with this condition have been shown on testicular biospy to have adequate spermatogenesis, and are theoretically producing sperm capable of fertilizing an oocyte. Yet epididymal transit was thought to be essential for the maturation of spermatozoa and development of their fertilizing ability since the characteristics of sperm motility improve as the sperm passes through the cauda. However recent studies in man have shown that spermatozoa aspirated from the obstructed caput epididymis and ductuli efferentia are, in fact, capable of fertilization in vitro. Microsurgical epididymal sperm aspiration (MESA) from the proximal region (caput) of the epididymis, obtained 0.5 × 106 sperm per ml, following washing and direct swim-up. Twelve oocytes were inseminated and three embryos were generated for transfer. The patient conceived and deliveried a healthy female baby weighting 2838 gm, on March 3, 1994. This is the first documentation in Taiwan of live birth resulting from MESA from a patient with CAVD combined with in vitro fertilization and embryo transfer.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalChinese Medical Journal (Taipei)
Volume57
Issue number2
Publication statusPublished - Feb 1996

Fingerprint

Sperm Retrieval
Embryo Transfer
Fertilization in Vitro
Spermatozoa
Pregnancy
Epididymis
Oocytes
Sperm Maturation
Sperm Motility
Male Infertility
Live Birth
Spermatogenesis
Taiwan
Documentation
Embryonic Structures
Congenital bilateral aplasia of vas deferens

Keywords

  • Congenital absence
  • In vitro fertilization
  • Male infertility
  • Vas deferens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Pregnancy following in vitro fertilization and embryo transfer by Microsurgical Epididymal Sperm Aspiration from a patient with Congenital Absence of the Vas Deferens: A case report",
abstract = "Congenital absence of the vas deferens (CAVD) has been considered a virtually untreatable cause of male infertility. Men with this condition have been shown on testicular biospy to have adequate spermatogenesis, and are theoretically producing sperm capable of fertilizing an oocyte. Yet epididymal transit was thought to be essential for the maturation of spermatozoa and development of their fertilizing ability since the characteristics of sperm motility improve as the sperm passes through the cauda. However recent studies in man have shown that spermatozoa aspirated from the obstructed caput epididymis and ductuli efferentia are, in fact, capable of fertilization in vitro. Microsurgical epididymal sperm aspiration (MESA) from the proximal region (caput) of the epididymis, obtained 0.5 × 106 sperm per ml, following washing and direct swim-up. Twelve oocytes were inseminated and three embryos were generated for transfer. The patient conceived and deliveried a healthy female baby weighting 2838 gm, on March 3, 1994. This is the first documentation in Taiwan of live birth resulting from MESA from a patient with CAVD combined with in vitro fertilization and embryo transfer.",
keywords = "Congenital absence, In vitro fertilization, Male infertility, Vas deferens",
author = "Tzeng, {Chii Rucy} and Hsiao, {Sen Yuan} and Chien, {Li Wei} and Chang, {Shu Ru} and Han-Sun Chiang and Wu, {Chien Chih} and Chen, {An Chiun}",
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T1 - Pregnancy following in vitro fertilization and embryo transfer by Microsurgical Epididymal Sperm Aspiration from a patient with Congenital Absence of the Vas Deferens

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AU - Chien, Li Wei

AU - Chang, Shu Ru

AU - Chiang, Han-Sun

AU - Wu, Chien Chih

AU - Chen, An Chiun

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