Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan

Chao Hsiun Tang, Chuan Song Wu, Tsong Hai Lee, Sheng Tzu Hung, Chen Yuan Charlie Yang, Cheng Hua Lee, Pao Hsien Chu

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Background and Purpose-The occurrence of preeclampsia-eclampsia during pregnancy has been reported to increase the risk of stroke in mainly Western populations. However, few studies have evaluated stroke risk in Asian populations and followed women beyond the early postpartum period. Thus, the present study determined the risk of stroke in women in Taiwan during pregnancy and the first postpartum year. Methods-A population-based cohort study was performed on 1 132 019 parturients during 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Stroke-free survival rates were estimated using the Kaplan-Meier method, and the log-rank test was used to examine the effect of preelampsia-eclampsia on the prevalence of stroke. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine the adjusted odds ratios of preeclampsia-eclampsia on the risk of hemorrhagic and ischemic stroke during pregnancy and within the first postpartum year. Results-The incidence of stroke was 21.47 cases per 100 000 deliveries. There were 139 cases of hemorrhagic stroke and 107 cases of ischemic stroke. The respective adjusted relative risk of preeclampsia-eclampsia for hemorrhagic and ischemic stroke were 10.68 (95% CI, 3.40 to 33.59) and 40.86 (95% CI, 12.14 to 137.47) within 3 months antepartum; 6.45 (95% CI, 1.42 to 29.29) and 34.71 (95% CI, 11.08 to 108.68) in the first 3 days postpartum; 5.61 (95% CI, 0.71 to 44.10) and 11.23 (95% CI, 2.45 to 51.59) from 3 days to 6 weeks postpartum; 11.76 (95% CI, 4.05 to 34.11) and 11.60 (95% CI, 3.30 to 40.82) from 6 weeks to 6 months pospartum; and 19.90 (95% CI, 7.75 to 51.11) and 4.35 (95% CI, 0.58 to 32.92) from 6 months to 12 months postpartum. Conclusions-Women with preeclampsia-eclampsia have a significantly higher risk of stroke during pregnancy and in the first postpartum year. These results suggest that women with preeclampsia-eclampsia should be closely monitored even after pregnancy.

Original languageEnglish
Pages (from-to)1162-1168
Number of pages7
JournalStroke
Volume40
Issue number4
DOIs
Publication statusPublished - Apr 1 2009

Fingerprint

Peripartum Period
Eclampsia
Pre-Eclampsia
Taiwan
Stroke
Postpartum Period
Pregnancy
Logistic Models
Population
Birth Certificates
National Health Programs
Obstetrics
Cohort Studies
Survival Rate
Odds Ratio

Keywords

  • Preeclampsia-eclampsia
  • Stroke in young adults
  • Taiwan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Medicine(all)

Cite this

Tang, C. H., Wu, C. S., Lee, T. H., Hung, S. T., Yang, C. Y. C., Lee, C. H., & Chu, P. H. (2009). Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan. Stroke, 40(4), 1162-1168. https://doi.org/10.1161/STROKEAHA.108.540880

Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan. / Tang, Chao Hsiun; Wu, Chuan Song; Lee, Tsong Hai; Hung, Sheng Tzu; Yang, Chen Yuan Charlie; Lee, Cheng Hua; Chu, Pao Hsien.

In: Stroke, Vol. 40, No. 4, 01.04.2009, p. 1162-1168.

Research output: Contribution to journalArticle

Tang, CH, Wu, CS, Lee, TH, Hung, ST, Yang, CYC, Lee, CH & Chu, PH 2009, 'Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan', Stroke, vol. 40, no. 4, pp. 1162-1168. https://doi.org/10.1161/STROKEAHA.108.540880
Tang, Chao Hsiun ; Wu, Chuan Song ; Lee, Tsong Hai ; Hung, Sheng Tzu ; Yang, Chen Yuan Charlie ; Lee, Cheng Hua ; Chu, Pao Hsien. / Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan. In: Stroke. 2009 ; Vol. 40, No. 4. pp. 1162-1168.
@article{45bf9bd7cf404c4dbafd8baa8995cc32,
title = "Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan",
abstract = "Background and Purpose-The occurrence of preeclampsia-eclampsia during pregnancy has been reported to increase the risk of stroke in mainly Western populations. However, few studies have evaluated stroke risk in Asian populations and followed women beyond the early postpartum period. Thus, the present study determined the risk of stroke in women in Taiwan during pregnancy and the first postpartum year. Methods-A population-based cohort study was performed on 1 132 019 parturients during 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Stroke-free survival rates were estimated using the Kaplan-Meier method, and the log-rank test was used to examine the effect of preelampsia-eclampsia on the prevalence of stroke. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine the adjusted odds ratios of preeclampsia-eclampsia on the risk of hemorrhagic and ischemic stroke during pregnancy and within the first postpartum year. Results-The incidence of stroke was 21.47 cases per 100 000 deliveries. There were 139 cases of hemorrhagic stroke and 107 cases of ischemic stroke. The respective adjusted relative risk of preeclampsia-eclampsia for hemorrhagic and ischemic stroke were 10.68 (95{\%} CI, 3.40 to 33.59) and 40.86 (95{\%} CI, 12.14 to 137.47) within 3 months antepartum; 6.45 (95{\%} CI, 1.42 to 29.29) and 34.71 (95{\%} CI, 11.08 to 108.68) in the first 3 days postpartum; 5.61 (95{\%} CI, 0.71 to 44.10) and 11.23 (95{\%} CI, 2.45 to 51.59) from 3 days to 6 weeks postpartum; 11.76 (95{\%} CI, 4.05 to 34.11) and 11.60 (95{\%} CI, 3.30 to 40.82) from 6 weeks to 6 months pospartum; and 19.90 (95{\%} CI, 7.75 to 51.11) and 4.35 (95{\%} CI, 0.58 to 32.92) from 6 months to 12 months postpartum. Conclusions-Women with preeclampsia-eclampsia have a significantly higher risk of stroke during pregnancy and in the first postpartum year. These results suggest that women with preeclampsia-eclampsia should be closely monitored even after pregnancy.",
keywords = "Preeclampsia-eclampsia, Stroke in young adults, Taiwan",
author = "Tang, {Chao Hsiun} and Wu, {Chuan Song} and Lee, {Tsong Hai} and Hung, {Sheng Tzu} and Yang, {Chen Yuan Charlie} and Lee, {Cheng Hua} and Chu, {Pao Hsien}",
year = "2009",
month = "4",
day = "1",
doi = "10.1161/STROKEAHA.108.540880",
language = "English",
volume = "40",
pages = "1162--1168",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan

AU - Tang, Chao Hsiun

AU - Wu, Chuan Song

AU - Lee, Tsong Hai

AU - Hung, Sheng Tzu

AU - Yang, Chen Yuan Charlie

AU - Lee, Cheng Hua

AU - Chu, Pao Hsien

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Background and Purpose-The occurrence of preeclampsia-eclampsia during pregnancy has been reported to increase the risk of stroke in mainly Western populations. However, few studies have evaluated stroke risk in Asian populations and followed women beyond the early postpartum period. Thus, the present study determined the risk of stroke in women in Taiwan during pregnancy and the first postpartum year. Methods-A population-based cohort study was performed on 1 132 019 parturients during 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Stroke-free survival rates were estimated using the Kaplan-Meier method, and the log-rank test was used to examine the effect of preelampsia-eclampsia on the prevalence of stroke. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine the adjusted odds ratios of preeclampsia-eclampsia on the risk of hemorrhagic and ischemic stroke during pregnancy and within the first postpartum year. Results-The incidence of stroke was 21.47 cases per 100 000 deliveries. There were 139 cases of hemorrhagic stroke and 107 cases of ischemic stroke. The respective adjusted relative risk of preeclampsia-eclampsia for hemorrhagic and ischemic stroke were 10.68 (95% CI, 3.40 to 33.59) and 40.86 (95% CI, 12.14 to 137.47) within 3 months antepartum; 6.45 (95% CI, 1.42 to 29.29) and 34.71 (95% CI, 11.08 to 108.68) in the first 3 days postpartum; 5.61 (95% CI, 0.71 to 44.10) and 11.23 (95% CI, 2.45 to 51.59) from 3 days to 6 weeks postpartum; 11.76 (95% CI, 4.05 to 34.11) and 11.60 (95% CI, 3.30 to 40.82) from 6 weeks to 6 months pospartum; and 19.90 (95% CI, 7.75 to 51.11) and 4.35 (95% CI, 0.58 to 32.92) from 6 months to 12 months postpartum. Conclusions-Women with preeclampsia-eclampsia have a significantly higher risk of stroke during pregnancy and in the first postpartum year. These results suggest that women with preeclampsia-eclampsia should be closely monitored even after pregnancy.

AB - Background and Purpose-The occurrence of preeclampsia-eclampsia during pregnancy has been reported to increase the risk of stroke in mainly Western populations. However, few studies have evaluated stroke risk in Asian populations and followed women beyond the early postpartum period. Thus, the present study determined the risk of stroke in women in Taiwan during pregnancy and the first postpartum year. Methods-A population-based cohort study was performed on 1 132 019 parturients during 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Stroke-free survival rates were estimated using the Kaplan-Meier method, and the log-rank test was used to examine the effect of preelampsia-eclampsia on the prevalence of stroke. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine the adjusted odds ratios of preeclampsia-eclampsia on the risk of hemorrhagic and ischemic stroke during pregnancy and within the first postpartum year. Results-The incidence of stroke was 21.47 cases per 100 000 deliveries. There were 139 cases of hemorrhagic stroke and 107 cases of ischemic stroke. The respective adjusted relative risk of preeclampsia-eclampsia for hemorrhagic and ischemic stroke were 10.68 (95% CI, 3.40 to 33.59) and 40.86 (95% CI, 12.14 to 137.47) within 3 months antepartum; 6.45 (95% CI, 1.42 to 29.29) and 34.71 (95% CI, 11.08 to 108.68) in the first 3 days postpartum; 5.61 (95% CI, 0.71 to 44.10) and 11.23 (95% CI, 2.45 to 51.59) from 3 days to 6 weeks postpartum; 11.76 (95% CI, 4.05 to 34.11) and 11.60 (95% CI, 3.30 to 40.82) from 6 weeks to 6 months pospartum; and 19.90 (95% CI, 7.75 to 51.11) and 4.35 (95% CI, 0.58 to 32.92) from 6 months to 12 months postpartum. Conclusions-Women with preeclampsia-eclampsia have a significantly higher risk of stroke during pregnancy and in the first postpartum year. These results suggest that women with preeclampsia-eclampsia should be closely monitored even after pregnancy.

KW - Preeclampsia-eclampsia

KW - Stroke in young adults

KW - Taiwan

UR - http://www.scopus.com/inward/record.url?scp=65249166512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249166512&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.108.540880

DO - 10.1161/STROKEAHA.108.540880

M3 - Article

VL - 40

SP - 1162

EP - 1168

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 4

ER -