Preeclampsia and the Risk of Bronchopulmonary Dysplasia in VLBW Infants: A Population Based Study

Ting An Yen, Hwai I. Yang, Wu Shiun Hsieh, Hung Chieh Chou, Chien Yi Chen, Kuo Inn Tsou, Po Nien Tsao, Chyong Hsin Hsu, Shu Chi Mu, Hung Chih Lin, Chao Ching Huang, Kai Sheng Hsieh

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background:Preeclampsia remains a leading cause of maternal mortality and preterm delivery. Both preeclampsia and bronchopulmonary dysplasia (BPD) of prematurity are associated with impaired angiogenesis. However, the relationship between maternal preeclampsia and BPD remains controversial. This study aims to test whether or not preeclampsia is associated with development of BPD in a cohort of premature infants.Materials and Methods:We conducted a retrospective cohort study assessing the association between preeclampsia and the risk of developing BPD in very-low-birth-weight (VLBW) infants registered in the Premature Baby Foundation of Taiwan from 1997 through 2006. All 21 neonatal departments in Taiwan participated in the data collection. A total of 8,653 VLBW infants were registered in the database. The exclusion criteria included congenital anomalies, chromosome anomalies, infants that died before 36 weeks post-conceptual (PCA), and those whose BPD status were unavailable. BPD was defined as oxygen dependence at 36 weeks postmenstrual age. The association between maternal preeclampsia and BPD was assessed using a multivariate-adjusted logistic regression model.Results:In the end, a total of 5,753 cases were enrolled in this study. The incidence of preeclampsia was 14.7% (n=847) and the overall incidence of BPD was 34.9%. Infants with maternal preeclampsia had a higher gestational age, higher incidence of cesarean section and being small for their gestational age, lower incidence of respiratory distress syndrome, patent ductus arteriosus, and sepsis. BPD occurred significantly less frequently in the maternal preeclampsia group (24.1% vs. 36.7%; adjusted odds ratio: 0.78; 95% confidence interval, 0.62-0.98). Subgroup analysis showed that the association between preeclampsia and BPD was significant only in those VLBW infants with a gestational age between 31-34 weeks.Conclusion:This data supports the association between fetal exposure to maternal preeclampsia and a reduced risk of BPD in relatively mature VLBW infants.

Original languageEnglish
Article numbere75168
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 20 2013
Externally publishedYes

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bronchopulmonary dysplasia
pre-eclampsia
Bronchopulmonary Dysplasia
Very Low Birth Weight Infant
low birth weight
Pre-Eclampsia
Chromosomes
Population
Logistics
Oxygen
Mothers
Gestational Age
incidence
gestational age
Incidence
Taiwan
Logistic Models
small for gestational age
patent ductus arteriosus
premature birth

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Yen, T. A., Yang, H. I., Hsieh, W. S., Chou, H. C., Chen, C. Y., Tsou, K. I., ... Hsieh, K. S. (2013). Preeclampsia and the Risk of Bronchopulmonary Dysplasia in VLBW Infants: A Population Based Study. PLoS One, 8(9), [e75168]. https://doi.org/10.1371/journal.pone.0075168

Preeclampsia and the Risk of Bronchopulmonary Dysplasia in VLBW Infants : A Population Based Study. / Yen, Ting An; Yang, Hwai I.; Hsieh, Wu Shiun; Chou, Hung Chieh; Chen, Chien Yi; Tsou, Kuo Inn; Tsao, Po Nien; Hsu, Chyong Hsin; Mu, Shu Chi; Lin, Hung Chih; Huang, Chao Ching; Hsieh, Kai Sheng.

In: PLoS One, Vol. 8, No. 9, e75168, 20.09.2013.

Research output: Contribution to journalArticle

Yen, TA, Yang, HI, Hsieh, WS, Chou, HC, Chen, CY, Tsou, KI, Tsao, PN, Hsu, CH, Mu, SC, Lin, HC, Huang, CC & Hsieh, KS 2013, 'Preeclampsia and the Risk of Bronchopulmonary Dysplasia in VLBW Infants: A Population Based Study', PLoS One, vol. 8, no. 9, e75168. https://doi.org/10.1371/journal.pone.0075168
Yen, Ting An ; Yang, Hwai I. ; Hsieh, Wu Shiun ; Chou, Hung Chieh ; Chen, Chien Yi ; Tsou, Kuo Inn ; Tsao, Po Nien ; Hsu, Chyong Hsin ; Mu, Shu Chi ; Lin, Hung Chih ; Huang, Chao Ching ; Hsieh, Kai Sheng. / Preeclampsia and the Risk of Bronchopulmonary Dysplasia in VLBW Infants : A Population Based Study. In: PLoS One. 2013 ; Vol. 8, No. 9.
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abstract = "Background:Preeclampsia remains a leading cause of maternal mortality and preterm delivery. Both preeclampsia and bronchopulmonary dysplasia (BPD) of prematurity are associated with impaired angiogenesis. However, the relationship between maternal preeclampsia and BPD remains controversial. This study aims to test whether or not preeclampsia is associated with development of BPD in a cohort of premature infants.Materials and Methods:We conducted a retrospective cohort study assessing the association between preeclampsia and the risk of developing BPD in very-low-birth-weight (VLBW) infants registered in the Premature Baby Foundation of Taiwan from 1997 through 2006. All 21 neonatal departments in Taiwan participated in the data collection. A total of 8,653 VLBW infants were registered in the database. The exclusion criteria included congenital anomalies, chromosome anomalies, infants that died before 36 weeks post-conceptual (PCA), and those whose BPD status were unavailable. BPD was defined as oxygen dependence at 36 weeks postmenstrual age. The association between maternal preeclampsia and BPD was assessed using a multivariate-adjusted logistic regression model.Results:In the end, a total of 5,753 cases were enrolled in this study. The incidence of preeclampsia was 14.7{\%} (n=847) and the overall incidence of BPD was 34.9{\%}. Infants with maternal preeclampsia had a higher gestational age, higher incidence of cesarean section and being small for their gestational age, lower incidence of respiratory distress syndrome, patent ductus arteriosus, and sepsis. BPD occurred significantly less frequently in the maternal preeclampsia group (24.1{\%} vs. 36.7{\%}; adjusted odds ratio: 0.78; 95{\%} confidence interval, 0.62-0.98). Subgroup analysis showed that the association between preeclampsia and BPD was significant only in those VLBW infants with a gestational age between 31-34 weeks.Conclusion:This data supports the association between fetal exposure to maternal preeclampsia and a reduced risk of BPD in relatively mature VLBW infants.",
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