Preeclampsia and retinopathy of prematurity in very-low-birth-weight infants

A population-based study

Hsin Chung Huang, Hwai I. Yang, Hung Chieh Chou, Chien Yi Chen, Wu Shiun Hsieh, Kuo Inn Tsou, Po Nien Tsao, Chyong Hsin Hsu, Shu Chi Mu, Hung Chih Lin, Chao Ching Huang, Kai Sheng Hsieh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Preeclampsia and retinopathy of prematurity (ROP) are associated with impaired angiogenesis. Previous studies on the relationship between preeclampsia and ROP have produced conflicting results. The goal of this study was to evaluate the association between maternal preeclampsia and ROP using a large population-based cohort of very-low-birth-weight (VLBW) infants from 21 neonatal departments registered in the database of the Premature Baby Foundation of Taiwan. Multivariable logistic regression analysis was used to estimate the adjusted odds ratios (OR) and 95% confidence intervals (CI) for preeclampsia with reference to ROP and severe ROP. A total of 5,718 VLBW infants (844 cases with maternal preeclampsia) were included for analysis. The overall incidences of mild and severe ROP were 36.0% and 12.2%, respectively. Univariable analysis showed lower GA and lower birth weight, vaginal delivery, non-SGA, RDS, PDA, sepsis, transfusion, and absence of maternal preeclampsia to be associated with mild and severe ROP development. However, OR (95% CI) adjusted for the variables that were significant according to univariable analysis showed the risks of developing any-stage ROP and severe ROP for maternal preeclampsia to be 1.00 (0.84-1.20) and 0.89 (0.63-1.25), respectively. The results remained unchanged in stratified analyses according to SGA status. Our data showed that maternal preeclampsia was not associated with the subsequent development of any stage or severe ROP in VLBW infants.

Original languageEnglish
Article numbere0143248
JournalPLoS One
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 1 2015
Externally publishedYes

Fingerprint

pre-eclampsia
premature birth
retinal diseases
Retinopathy of Prematurity
Very Low Birth Weight Infant
low birth weight
Personal digital assistants
Pre-Eclampsia
Regression analysis
Logistics
Population
Mothers
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
risk analysis
infants
angiogenesis
Taiwan

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Huang, H. C., Yang, H. I., Chou, H. C., Chen, C. Y., Hsieh, W. S., Tsou, K. I., ... Hsieh, K. S. (2015). Preeclampsia and retinopathy of prematurity in very-low-birth-weight infants: A population-based study. PLoS One, 10(11), [e0143248]. https://doi.org/10.1371/journal.pone.0143248

Preeclampsia and retinopathy of prematurity in very-low-birth-weight infants : A population-based study. / Huang, Hsin Chung; Yang, Hwai I.; Chou, Hung Chieh; Chen, Chien Yi; Hsieh, Wu Shiun; Tsou, Kuo Inn; Tsao, Po Nien; Hsu, Chyong Hsin; Mu, Shu Chi; Lin, Hung Chih; Huang, Chao Ching; Hsieh, Kai Sheng.

In: PLoS One, Vol. 10, No. 11, e0143248, 01.11.2015.

Research output: Contribution to journalArticle

Huang, HC, Yang, HI, Chou, HC, Chen, CY, Hsieh, WS, Tsou, KI, Tsao, PN, Hsu, CH, Mu, SC, Lin, HC, Huang, CC & Hsieh, KS 2015, 'Preeclampsia and retinopathy of prematurity in very-low-birth-weight infants: A population-based study', PLoS One, vol. 10, no. 11, e0143248. https://doi.org/10.1371/journal.pone.0143248
Huang, Hsin Chung ; Yang, Hwai I. ; Chou, Hung Chieh ; Chen, Chien Yi ; Hsieh, Wu Shiun ; Tsou, Kuo Inn ; Tsao, Po Nien ; Hsu, Chyong Hsin ; Mu, Shu Chi ; Lin, Hung Chih ; Huang, Chao Ching ; Hsieh, Kai Sheng. / Preeclampsia and retinopathy of prematurity in very-low-birth-weight infants : A population-based study. In: PLoS One. 2015 ; Vol. 10, No. 11.
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