Predictors of Poor Outcome in Non-Diabetic Chronic Kidney Disease Patients with Gouty Arthritis

Chun-Yu Chen, I-Wen Wu, Heng-Jung Hsu, Mai-Szu Wu, Chin-Chan Lee

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Hyperuricemia and gouty arthritis are prevalent in patient with chronic kidney disease (CKD). Few prospective studies have evaluated the possible factors affecting the clinical outcomes of CKD patients with tophaceous gout. METHODS: This is a prospective observational study evaluating renal progression and all-cause mortality in a selected cohort of patients. All non-diabetic patients from different CKD stages who participate the multidisciplinary pre-dialysis education (MPE) program of Chang Gung Memorial Hospital at Keelung were enrolled in this study. All patients were followed-up to September 2011 and noted with clinically poor outcomes (defi ned as renal progression requiring dialysis or all-cause mortality). RESULTS: A total of 138 patients were enrolled in the study. Sixteen (11.59%) of these patients (death: 7 and renal progression: 9) had poor outcomes after a mean follow-up of 34 ± 15 months. Cox regression analysis followed by multivariate analysis showed that high serum creatinine, low hemoglobin (Hb), high systolic blood pressure (SBP) and low waist circumference were associated with poor outcomes independent of age, gender, albumin levels, serum uric acid, calcium, phosphorus, estimated glomerular fi ltration rate, and body-mass index (BMI). CONCLUSION: Serum creatinine, Hb, SBP and waist circumference may help in predicting the risk of poor outcomes in CKD patients with gouty arthritis.
Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalActa Nephrologica
Volume29
Issue number1
DOIs
Publication statusPublished - 2015

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Gouty Arthritis
Chronic Renal Insufficiency
Waist Circumference
Blood Pressure
Kidney
Dialysis
Creatinine
Hemoglobins
Prospective Studies
Hyperuricemia
Mortality
Gout
Uric Acid
Serum
Serum Albumin
Phosphorus
Observational Studies
Body Mass Index
Multivariate Analysis
Regression Analysis

Keywords

  • chronic kidney disease
  • chronic urate nephropathy
  • gouty arthritis
  • uric acid

Cite this

Predictors of Poor Outcome in Non-Diabetic Chronic Kidney Disease Patients with Gouty Arthritis. / Chen, Chun-Yu; Wu, I-Wen; Hsu, Heng-Jung; Wu, Mai-Szu; Lee, Chin-Chan.

In: Acta Nephrologica, Vol. 29, No. 1, 2015, p. 19-26.

Research output: Contribution to journalArticle

Chen, Chun-Yu ; Wu, I-Wen ; Hsu, Heng-Jung ; Wu, Mai-Szu ; Lee, Chin-Chan. / Predictors of Poor Outcome in Non-Diabetic Chronic Kidney Disease Patients with Gouty Arthritis. In: Acta Nephrologica. 2015 ; Vol. 29, No. 1. pp. 19-26.
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AB - BACKGROUND: Hyperuricemia and gouty arthritis are prevalent in patient with chronic kidney disease (CKD). Few prospective studies have evaluated the possible factors affecting the clinical outcomes of CKD patients with tophaceous gout. METHODS: This is a prospective observational study evaluating renal progression and all-cause mortality in a selected cohort of patients. All non-diabetic patients from different CKD stages who participate the multidisciplinary pre-dialysis education (MPE) program of Chang Gung Memorial Hospital at Keelung were enrolled in this study. All patients were followed-up to September 2011 and noted with clinically poor outcomes (defi ned as renal progression requiring dialysis or all-cause mortality). RESULTS: A total of 138 patients were enrolled in the study. Sixteen (11.59%) of these patients (death: 7 and renal progression: 9) had poor outcomes after a mean follow-up of 34 ± 15 months. Cox regression analysis followed by multivariate analysis showed that high serum creatinine, low hemoglobin (Hb), high systolic blood pressure (SBP) and low waist circumference were associated with poor outcomes independent of age, gender, albumin levels, serum uric acid, calcium, phosphorus, estimated glomerular fi ltration rate, and body-mass index (BMI). CONCLUSION: Serum creatinine, Hb, SBP and waist circumference may help in predicting the risk of poor outcomes in CKD patients with gouty arthritis.

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