Predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation

Implication for catheter ablation

Shih Huang Lee, Ching Tai Tai, Ming Hsiung Hsieh, Hsuan Ming Tsao, Yenn Jiang Lin, Shih Lin Chang, Jin Long Huang, Kun Tai Lee, Yi Jen Chen, Jun Jack Cheng, Shih Ann Chen

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

OBJECTIVES: The purpose of this study was to investigate the predictor of non-pulmonary vein (PV) ectopic beats initiating paroxysmal atrial fibrillation (PAF). BACKGROUND: Non-PV ectopic beats can initiate PAF in some patients and play an important role in the recurrence of PAF after PV isolation. Information on the predictors of non-PV ectopic beats initiating PAF is unknown. METHODS: This study included 293 patients (215 men and 78 women, age 60 ± 14 years) with clinically documented drug-refractory PAF. Of the 94 patients with non-PV ectopic beats initiating PAF, 38 (40%) patients had superior vena cava (SVC) ectopic beats and 32 (34%) had left atrial posterior free wall (LAPFW) ectopic beats. RESULTS: In a univariate analysis, only female gender was related to the presence of non-PV (p = 0.016) and SVC ectopic beats (p = 0.012). Right atrial enlargement (p = 0.005) and left atrial enlargement (p <0.001) were related to the presence of LAPFW ectopic beats. In a multivariate analysis, female gender (p = 0.043; odds ratio 2.00, 95% confidence interval [CI] 1.02 to 3.92) and left atrial enlargement (p = 0.007; odds ratio 2.34, 95% CI 1.27 to 4.32) could predict the presence of non-PV ectopic beats. Subgroup analysis showed that female gender could predict the presence of SVC ectopic beats (p = 0.039; odds ratio 2.14, 95% CI 1.04 to 4.43). In contrast, left atrial enlargement could predict the presence of LAPFW ectopic beats (p = 0.002; odds ratio 3.89, 95% CI 1.62 to 9.38). CONCLUSIONS: The location of non-PV ectopic beats initiating PAF can be predicted by both gender and left atrial enlargement.

Original languageEnglish
Pages (from-to)1054-1059
Number of pages6
JournalJournal of the American College of Cardiology
Volume46
Issue number6
DOIs
Publication statusPublished - Sep 20 2005
Externally publishedYes

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Catheter Ablation
Atrial Fibrillation
Veins
Superior Vena Cava
Odds Ratio
Confidence Intervals
Pulmonary Veins
Multivariate Analysis
Recurrence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation : Implication for catheter ablation. / Lee, Shih Huang; Tai, Ching Tai; Hsieh, Ming Hsiung; Tsao, Hsuan Ming; Lin, Yenn Jiang; Chang, Shih Lin; Huang, Jin Long; Lee, Kun Tai; Chen, Yi Jen; Cheng, Jun Jack; Chen, Shih Ann.

In: Journal of the American College of Cardiology, Vol. 46, No. 6, 20.09.2005, p. 1054-1059.

Research output: Contribution to journalArticle

Lee, Shih Huang ; Tai, Ching Tai ; Hsieh, Ming Hsiung ; Tsao, Hsuan Ming ; Lin, Yenn Jiang ; Chang, Shih Lin ; Huang, Jin Long ; Lee, Kun Tai ; Chen, Yi Jen ; Cheng, Jun Jack ; Chen, Shih Ann. / Predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation : Implication for catheter ablation. In: Journal of the American College of Cardiology. 2005 ; Vol. 46, No. 6. pp. 1054-1059.
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abstract = "OBJECTIVES: The purpose of this study was to investigate the predictor of non-pulmonary vein (PV) ectopic beats initiating paroxysmal atrial fibrillation (PAF). BACKGROUND: Non-PV ectopic beats can initiate PAF in some patients and play an important role in the recurrence of PAF after PV isolation. Information on the predictors of non-PV ectopic beats initiating PAF is unknown. METHODS: This study included 293 patients (215 men and 78 women, age 60 ± 14 years) with clinically documented drug-refractory PAF. Of the 94 patients with non-PV ectopic beats initiating PAF, 38 (40{\%}) patients had superior vena cava (SVC) ectopic beats and 32 (34{\%}) had left atrial posterior free wall (LAPFW) ectopic beats. RESULTS: In a univariate analysis, only female gender was related to the presence of non-PV (p = 0.016) and SVC ectopic beats (p = 0.012). Right atrial enlargement (p = 0.005) and left atrial enlargement (p <0.001) were related to the presence of LAPFW ectopic beats. In a multivariate analysis, female gender (p = 0.043; odds ratio 2.00, 95{\%} confidence interval [CI] 1.02 to 3.92) and left atrial enlargement (p = 0.007; odds ratio 2.34, 95{\%} CI 1.27 to 4.32) could predict the presence of non-PV ectopic beats. Subgroup analysis showed that female gender could predict the presence of SVC ectopic beats (p = 0.039; odds ratio 2.14, 95{\%} CI 1.04 to 4.43). In contrast, left atrial enlargement could predict the presence of LAPFW ectopic beats (p = 0.002; odds ratio 3.89, 95{\%} CI 1.62 to 9.38). CONCLUSIONS: The location of non-PV ectopic beats initiating PAF can be predicted by both gender and left atrial enlargement.",
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T1 - Predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation

T2 - Implication for catheter ablation

AU - Lee, Shih Huang

AU - Tai, Ching Tai

AU - Hsieh, Ming Hsiung

AU - Tsao, Hsuan Ming

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Huang, Jin Long

AU - Lee, Kun Tai

AU - Chen, Yi Jen

AU - Cheng, Jun Jack

AU - Chen, Shih Ann

PY - 2005/9/20

Y1 - 2005/9/20

N2 - OBJECTIVES: The purpose of this study was to investigate the predictor of non-pulmonary vein (PV) ectopic beats initiating paroxysmal atrial fibrillation (PAF). BACKGROUND: Non-PV ectopic beats can initiate PAF in some patients and play an important role in the recurrence of PAF after PV isolation. Information on the predictors of non-PV ectopic beats initiating PAF is unknown. METHODS: This study included 293 patients (215 men and 78 women, age 60 ± 14 years) with clinically documented drug-refractory PAF. Of the 94 patients with non-PV ectopic beats initiating PAF, 38 (40%) patients had superior vena cava (SVC) ectopic beats and 32 (34%) had left atrial posterior free wall (LAPFW) ectopic beats. RESULTS: In a univariate analysis, only female gender was related to the presence of non-PV (p = 0.016) and SVC ectopic beats (p = 0.012). Right atrial enlargement (p = 0.005) and left atrial enlargement (p <0.001) were related to the presence of LAPFW ectopic beats. In a multivariate analysis, female gender (p = 0.043; odds ratio 2.00, 95% confidence interval [CI] 1.02 to 3.92) and left atrial enlargement (p = 0.007; odds ratio 2.34, 95% CI 1.27 to 4.32) could predict the presence of non-PV ectopic beats. Subgroup analysis showed that female gender could predict the presence of SVC ectopic beats (p = 0.039; odds ratio 2.14, 95% CI 1.04 to 4.43). In contrast, left atrial enlargement could predict the presence of LAPFW ectopic beats (p = 0.002; odds ratio 3.89, 95% CI 1.62 to 9.38). CONCLUSIONS: The location of non-PV ectopic beats initiating PAF can be predicted by both gender and left atrial enlargement.

AB - OBJECTIVES: The purpose of this study was to investigate the predictor of non-pulmonary vein (PV) ectopic beats initiating paroxysmal atrial fibrillation (PAF). BACKGROUND: Non-PV ectopic beats can initiate PAF in some patients and play an important role in the recurrence of PAF after PV isolation. Information on the predictors of non-PV ectopic beats initiating PAF is unknown. METHODS: This study included 293 patients (215 men and 78 women, age 60 ± 14 years) with clinically documented drug-refractory PAF. Of the 94 patients with non-PV ectopic beats initiating PAF, 38 (40%) patients had superior vena cava (SVC) ectopic beats and 32 (34%) had left atrial posterior free wall (LAPFW) ectopic beats. RESULTS: In a univariate analysis, only female gender was related to the presence of non-PV (p = 0.016) and SVC ectopic beats (p = 0.012). Right atrial enlargement (p = 0.005) and left atrial enlargement (p <0.001) were related to the presence of LAPFW ectopic beats. In a multivariate analysis, female gender (p = 0.043; odds ratio 2.00, 95% confidence interval [CI] 1.02 to 3.92) and left atrial enlargement (p = 0.007; odds ratio 2.34, 95% CI 1.27 to 4.32) could predict the presence of non-PV ectopic beats. Subgroup analysis showed that female gender could predict the presence of SVC ectopic beats (p = 0.039; odds ratio 2.14, 95% CI 1.04 to 4.43). In contrast, left atrial enlargement could predict the presence of LAPFW ectopic beats (p = 0.002; odds ratio 3.89, 95% CI 1.62 to 9.38). CONCLUSIONS: The location of non-PV ectopic beats initiating PAF can be predicted by both gender and left atrial enlargement.

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