Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care

羅 鴻源(Horng-Yuan Lou), 羅 鴻基(Hong-Ji Luo), 謝 清睿(Ching-Ruey Hsieh), 張 甄(Tiong Cheng), 鄭 仰志(Yang-Chih Cheng), 方 聖惟(Sheng-Uei Fang), 劉 正典(Jean-Dean Liu), 潘 憲(Shiann Pan), 張 君照(Chun-Chao Chang)

Research output: Contribution to journalArticle

Abstract

Background: Despite progress in the diagnosis and management of pyogenic liver abscess, the mortality rate remains high in critically ill patients. There have been limited studies on patients with pyogenic liver abscess requiring intensive care. The aim of this study was to assess the risk factors of mortality among patients with pyogenic liver abscess treated in intensive care unit (ICU).
Methods: Thirty-five patients with pyogenic liver abscess admitted to ICU, between January 2003 and June 2009, were studied retrospectively. Parameters including general characteristics, clinical presentations, Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores, features of liver abscess and laboratory data were reviewed. The main outcome measure was survival. Univariate and subsequent multivariate logistic regression analyses were performed to assess the risk factors for mortality. The best cut-off for each identified independent risk factor for mortality was then investigated.
Results: Univariate analysis implicated APACHE Ⅱ scores on admission, abscess size and gas formation as prognostic factors of mortality. Multivariate analysis showed higher APACHE Ⅱ scores on ICU admission (OR=1.387; 95% CI=1.106-1.739) and size of the liver abscess (OR=2.986; 95% CI=1.060-3.723) as independent prognostic factors for mortality. Finally, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were found to be relatively more accurate in predicting mortality in the study population.
Conclusion: In patients with pyogenic liver abscess requiring intensive care, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were accurate predictors of mortality.
Original languageEnglish
Pages (from-to)416-423
Number of pages8
JournalGastroenterological Journal of Taiwan
Volume27
Issue number4
Publication statusPublished - 2010

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Pyogenic Liver Abscess
Critical Care
APACHE
Mortality
Intensive Care Units
Liver Abscess
Liver
Critical Illness
Abscess
Multivariate Analysis
Gases
Logistic Models
Regression Analysis
Outcome Assessment (Health Care)

Keywords

  • 細菌性肝膿瘍
  • 死亡率
  • pyogenic liver abscess
  • mortality

Cite this

羅鴻源(Horng-Yuan L, 羅鴻基(Hong-Ji L, 謝清睿(Ching-Ruey H, 張甄(Tiong C, 鄭仰志(Yang-Chih C, 方聖惟(Sheng-Uei F, ... 張君照(Chun-Chao C (2010). Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care. Gastroenterological Journal of Taiwan, 27(4), 416-423.

Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care. / 羅鴻源(Horng-Yuan Lou); 羅鴻基(Hong-Ji Luo); 謝清睿(Ching-Ruey Hsieh); 張甄(Tiong Cheng); 鄭仰志(Yang-Chih Cheng); 方聖惟(Sheng-Uei Fang); 劉正典(Jean-Dean Liu); 潘憲(Shiann Pan); 張君照(Chun-Chao Chang).

In: Gastroenterological Journal of Taiwan, Vol. 27, No. 4, 2010, p. 416-423.

Research output: Contribution to journalArticle

羅鴻源(Horng-YuanL, 羅鴻基(Hong-JiL, 謝清睿(Ching-RueyH, 張甄(TiongC, 鄭仰志(Yang-ChihC, 方聖惟(Sheng-UeiF, 劉正典(Jean-DeanL, 潘憲(ShiannP & 張君照(Chun-ChaoC 2010, 'Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care', Gastroenterological Journal of Taiwan, vol. 27, no. 4, pp. 416-423.
羅鴻源(Horng-YuanL, 羅鴻基(Hong-JiL, 謝清睿(Ching-RueyH, 張甄(TiongC, 鄭仰志(Yang-ChihC, 方聖惟(Sheng-UeiF et al. Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care. Gastroenterological Journal of Taiwan. 2010;27(4):416-423.
羅鴻源(Horng-Yuan Lou) ; 羅鴻基(Hong-Ji Luo) ; 謝清睿(Ching-Ruey Hsieh) ; 張甄(Tiong Cheng) ; 鄭仰志(Yang-Chih Cheng) ; 方聖惟(Sheng-Uei Fang) ; 劉正典(Jean-Dean Liu) ; 潘憲(Shiann Pan) ; 張君照(Chun-Chao Chang). / Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care. In: Gastroenterological Journal of Taiwan. 2010 ; Vol. 27, No. 4. pp. 416-423.
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abstract = "Background: Despite progress in the diagnosis and management of pyogenic liver abscess, the mortality rate remains high in critically ill patients. There have been limited studies on patients with pyogenic liver abscess requiring intensive care. The aim of this study was to assess the risk factors of mortality among patients with pyogenic liver abscess treated in intensive care unit (ICU).Methods: Thirty-five patients with pyogenic liver abscess admitted to ICU, between January 2003 and June 2009, were studied retrospectively. Parameters including general characteristics, clinical presentations, Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores, features of liver abscess and laboratory data were reviewed. The main outcome measure was survival. Univariate and subsequent multivariate logistic regression analyses were performed to assess the risk factors for mortality. The best cut-off for each identified independent risk factor for mortality was then investigated.Results: Univariate analysis implicated APACHE Ⅱ scores on admission, abscess size and gas formation as prognostic factors of mortality. Multivariate analysis showed higher APACHE Ⅱ scores on ICU admission (OR=1.387; 95{\%} CI=1.106-1.739) and size of the liver abscess (OR=2.986; 95{\%} CI=1.060-3.723) as independent prognostic factors for mortality. Finally, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were found to be relatively more accurate in predicting mortality in the study population.Conclusion: In patients with pyogenic liver abscess requiring intensive care, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were accurate predictors of mortality.",
keywords = "細菌性肝膿瘍, 死亡率, pyogenic liver abscess, mortality",
author = "羅, {鴻源(Horng-Yuan Lou)} and 羅, {鴻基(Hong-Ji Luo)} and 謝, {清睿(Ching-Ruey Hsieh)} and 張, {甄(Tiong Cheng)} and 鄭, {仰志(Yang-Chih Cheng)} and 方, {聖惟(Sheng-Uei Fang)} and 劉, {正典(Jean-Dean Liu)} and 潘, {憲(Shiann Pan)} and 張, {君照(Chun-Chao Chang)}",
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TY - JOUR

T1 - Predictors of Mortality in Patients with Pyogenic Liver Abscess Requiring Intensive Care

AU - 羅, 鴻源(Horng-Yuan Lou)

AU - 羅, 鴻基(Hong-Ji Luo)

AU - 謝, 清睿(Ching-Ruey Hsieh)

AU - 張, 甄(Tiong Cheng)

AU - 鄭, 仰志(Yang-Chih Cheng)

AU - 方, 聖惟(Sheng-Uei Fang)

AU - 劉, 正典(Jean-Dean Liu)

AU - 潘, 憲(Shiann Pan)

AU - 張, 君照(Chun-Chao Chang)

PY - 2010

Y1 - 2010

N2 - Background: Despite progress in the diagnosis and management of pyogenic liver abscess, the mortality rate remains high in critically ill patients. There have been limited studies on patients with pyogenic liver abscess requiring intensive care. The aim of this study was to assess the risk factors of mortality among patients with pyogenic liver abscess treated in intensive care unit (ICU).Methods: Thirty-five patients with pyogenic liver abscess admitted to ICU, between January 2003 and June 2009, were studied retrospectively. Parameters including general characteristics, clinical presentations, Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores, features of liver abscess and laboratory data were reviewed. The main outcome measure was survival. Univariate and subsequent multivariate logistic regression analyses were performed to assess the risk factors for mortality. The best cut-off for each identified independent risk factor for mortality was then investigated.Results: Univariate analysis implicated APACHE Ⅱ scores on admission, abscess size and gas formation as prognostic factors of mortality. Multivariate analysis showed higher APACHE Ⅱ scores on ICU admission (OR=1.387; 95% CI=1.106-1.739) and size of the liver abscess (OR=2.986; 95% CI=1.060-3.723) as independent prognostic factors for mortality. Finally, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were found to be relatively more accurate in predicting mortality in the study population.Conclusion: In patients with pyogenic liver abscess requiring intensive care, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were accurate predictors of mortality.

AB - Background: Despite progress in the diagnosis and management of pyogenic liver abscess, the mortality rate remains high in critically ill patients. There have been limited studies on patients with pyogenic liver abscess requiring intensive care. The aim of this study was to assess the risk factors of mortality among patients with pyogenic liver abscess treated in intensive care unit (ICU).Methods: Thirty-five patients with pyogenic liver abscess admitted to ICU, between January 2003 and June 2009, were studied retrospectively. Parameters including general characteristics, clinical presentations, Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ scores, features of liver abscess and laboratory data were reviewed. The main outcome measure was survival. Univariate and subsequent multivariate logistic regression analyses were performed to assess the risk factors for mortality. The best cut-off for each identified independent risk factor for mortality was then investigated.Results: Univariate analysis implicated APACHE Ⅱ scores on admission, abscess size and gas formation as prognostic factors of mortality. Multivariate analysis showed higher APACHE Ⅱ scores on ICU admission (OR=1.387; 95% CI=1.106-1.739) and size of the liver abscess (OR=2.986; 95% CI=1.060-3.723) as independent prognostic factors for mortality. Finally, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were found to be relatively more accurate in predicting mortality in the study population.Conclusion: In patients with pyogenic liver abscess requiring intensive care, APACHE Ⅱ scores≥17 and the diameter of liver abscess≥5 cm were accurate predictors of mortality.

KW - 細菌性肝膿瘍

KW - 死亡率

KW - pyogenic liver abscess

KW - mortality

M3 - Article

VL - 27

SP - 416

EP - 423

JO - Gastroenterological Journal of Taiwan

JF - Gastroenterological Journal of Taiwan

SN - 1013-7696

IS - 4

ER -