Predictors of early and late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation

Shih Huang Lee, Ching Tai Tai, Ming Hsiung Hsieh, Chin Feng Tsai, Yung Kuo Lin, Hsuan Ming Tsao, Wen Chung Yu, Jin Long Huang, Kow Chang Ueng, Jun Jack Cheng, Yu An Ding, Shih Ann Chen

Research output: Contribution to journalArticle

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Abstract

Introduction: The outcome of patients with early recurrence of atrial fibrillation (AF) (within one month) after ablation procedure is controversial. Furthermore, the predictors of early and late (up to mean follow-up 30 months) recurrence of AF are not investigated in depth. Aims of the Study: The aim of the present study was to investigate the predictors of early and late recurrence of AF after catheter ablation of arrhythmogenic foci initiating AF in patients with paroxysmal AF. Methods and Results: The study included 207 patients (155 men; mean age 62 ± 13 years) who received catheter ablation of paroxysmal AF. Eighty-one (39%) patients had early recurrence of AF. Five clinical variables were related to the early recurrence of AF: (1) old age (≥65 years) (P = 0.004); (2) presence of associated cardiovascular disease (P = 0.01); (3) presence of multiple AF foci (P = 0.004); (4) presence of AF foci from left atrial free wall (P = 0.039); (5) left atrial enlargement (P = 0.038). Multivariate analysis demonstrated that presence of multiple AF foci could predict early recurrence of AF (P = 0.013; ratio = 2.24; 95% CI 1.18 to 4.25). During the follow-up period (30 ± 11 months), 70 (34%) patients had late recurrence of AF, and two clinical variables were related to the late recurrence of AF: (1) presence of early recurrence of AF (P = 0.025); (2) presence of multiple AF foci (P = 0.034). Multivariate analysis found that presence of early recurrence of AF could predict late recurrence of AF (P = 0.046; hazard ratio = 1.62; 95% CI 1.01 to 2.59). Late recurrence of AF happened in 35 (43%) of the 81 patients with early recurrence of AF, and in 35 (28%) of the 126 patients without early recurrence of AF. Conclusions: Early AF recurrence could predict late AF recurrence.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalJournal of Interventional Cardiac Electrophysiology
Volume10
Issue number3
DOIs
Publication statusPublished - Jun 2004
Externally publishedYes

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Catheter Ablation
Atrial Fibrillation
Recurrence
Multivariate Analysis

Keywords

  • Ablation
  • Atrial fibrillation
  • Radiofrequency
  • Recurrence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Predictors of early and late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation. / Lee, Shih Huang; Tai, Ching Tai; Hsieh, Ming Hsiung; Tsai, Chin Feng; Lin, Yung Kuo; Tsao, Hsuan Ming; Yu, Wen Chung; Huang, Jin Long; Ueng, Kow Chang; Cheng, Jun Jack; Ding, Yu An; Chen, Shih Ann.

In: Journal of Interventional Cardiac Electrophysiology, Vol. 10, No. 3, 06.2004, p. 221-226.

Research output: Contribution to journalArticle

Lee, Shih Huang ; Tai, Ching Tai ; Hsieh, Ming Hsiung ; Tsai, Chin Feng ; Lin, Yung Kuo ; Tsao, Hsuan Ming ; Yu, Wen Chung ; Huang, Jin Long ; Ueng, Kow Chang ; Cheng, Jun Jack ; Ding, Yu An ; Chen, Shih Ann. / Predictors of early and late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation. In: Journal of Interventional Cardiac Electrophysiology. 2004 ; Vol. 10, No. 3. pp. 221-226.
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abstract = "Introduction: The outcome of patients with early recurrence of atrial fibrillation (AF) (within one month) after ablation procedure is controversial. Furthermore, the predictors of early and late (up to mean follow-up 30 months) recurrence of AF are not investigated in depth. Aims of the Study: The aim of the present study was to investigate the predictors of early and late recurrence of AF after catheter ablation of arrhythmogenic foci initiating AF in patients with paroxysmal AF. Methods and Results: The study included 207 patients (155 men; mean age 62 ± 13 years) who received catheter ablation of paroxysmal AF. Eighty-one (39{\%}) patients had early recurrence of AF. Five clinical variables were related to the early recurrence of AF: (1) old age (≥65 years) (P = 0.004); (2) presence of associated cardiovascular disease (P = 0.01); (3) presence of multiple AF foci (P = 0.004); (4) presence of AF foci from left atrial free wall (P = 0.039); (5) left atrial enlargement (P = 0.038). Multivariate analysis demonstrated that presence of multiple AF foci could predict early recurrence of AF (P = 0.013; ratio = 2.24; 95{\%} CI 1.18 to 4.25). During the follow-up period (30 ± 11 months), 70 (34{\%}) patients had late recurrence of AF, and two clinical variables were related to the late recurrence of AF: (1) presence of early recurrence of AF (P = 0.025); (2) presence of multiple AF foci (P = 0.034). Multivariate analysis found that presence of early recurrence of AF could predict late recurrence of AF (P = 0.046; hazard ratio = 1.62; 95{\%} CI 1.01 to 2.59). Late recurrence of AF happened in 35 (43{\%}) of the 81 patients with early recurrence of AF, and in 35 (28{\%}) of the 126 patients without early recurrence of AF. Conclusions: Early AF recurrence could predict late AF recurrence.",
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author = "Lee, {Shih Huang} and Tai, {Ching Tai} and Hsieh, {Ming Hsiung} and Tsai, {Chin Feng} and Lin, {Yung Kuo} and Tsao, {Hsuan Ming} and Yu, {Wen Chung} and Huang, {Jin Long} and Ueng, {Kow Chang} and Cheng, {Jun Jack} and Ding, {Yu An} and Chen, {Shih Ann}",
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T1 - Predictors of early and late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation

AU - Lee, Shih Huang

AU - Tai, Ching Tai

AU - Hsieh, Ming Hsiung

AU - Tsai, Chin Feng

AU - Lin, Yung Kuo

AU - Tsao, Hsuan Ming

AU - Yu, Wen Chung

AU - Huang, Jin Long

AU - Ueng, Kow Chang

AU - Cheng, Jun Jack

AU - Ding, Yu An

AU - Chen, Shih Ann

PY - 2004/6

Y1 - 2004/6

N2 - Introduction: The outcome of patients with early recurrence of atrial fibrillation (AF) (within one month) after ablation procedure is controversial. Furthermore, the predictors of early and late (up to mean follow-up 30 months) recurrence of AF are not investigated in depth. Aims of the Study: The aim of the present study was to investigate the predictors of early and late recurrence of AF after catheter ablation of arrhythmogenic foci initiating AF in patients with paroxysmal AF. Methods and Results: The study included 207 patients (155 men; mean age 62 ± 13 years) who received catheter ablation of paroxysmal AF. Eighty-one (39%) patients had early recurrence of AF. Five clinical variables were related to the early recurrence of AF: (1) old age (≥65 years) (P = 0.004); (2) presence of associated cardiovascular disease (P = 0.01); (3) presence of multiple AF foci (P = 0.004); (4) presence of AF foci from left atrial free wall (P = 0.039); (5) left atrial enlargement (P = 0.038). Multivariate analysis demonstrated that presence of multiple AF foci could predict early recurrence of AF (P = 0.013; ratio = 2.24; 95% CI 1.18 to 4.25). During the follow-up period (30 ± 11 months), 70 (34%) patients had late recurrence of AF, and two clinical variables were related to the late recurrence of AF: (1) presence of early recurrence of AF (P = 0.025); (2) presence of multiple AF foci (P = 0.034). Multivariate analysis found that presence of early recurrence of AF could predict late recurrence of AF (P = 0.046; hazard ratio = 1.62; 95% CI 1.01 to 2.59). Late recurrence of AF happened in 35 (43%) of the 81 patients with early recurrence of AF, and in 35 (28%) of the 126 patients without early recurrence of AF. Conclusions: Early AF recurrence could predict late AF recurrence.

AB - Introduction: The outcome of patients with early recurrence of atrial fibrillation (AF) (within one month) after ablation procedure is controversial. Furthermore, the predictors of early and late (up to mean follow-up 30 months) recurrence of AF are not investigated in depth. Aims of the Study: The aim of the present study was to investigate the predictors of early and late recurrence of AF after catheter ablation of arrhythmogenic foci initiating AF in patients with paroxysmal AF. Methods and Results: The study included 207 patients (155 men; mean age 62 ± 13 years) who received catheter ablation of paroxysmal AF. Eighty-one (39%) patients had early recurrence of AF. Five clinical variables were related to the early recurrence of AF: (1) old age (≥65 years) (P = 0.004); (2) presence of associated cardiovascular disease (P = 0.01); (3) presence of multiple AF foci (P = 0.004); (4) presence of AF foci from left atrial free wall (P = 0.039); (5) left atrial enlargement (P = 0.038). Multivariate analysis demonstrated that presence of multiple AF foci could predict early recurrence of AF (P = 0.013; ratio = 2.24; 95% CI 1.18 to 4.25). During the follow-up period (30 ± 11 months), 70 (34%) patients had late recurrence of AF, and two clinical variables were related to the late recurrence of AF: (1) presence of early recurrence of AF (P = 0.025); (2) presence of multiple AF foci (P = 0.034). Multivariate analysis found that presence of early recurrence of AF could predict late recurrence of AF (P = 0.046; hazard ratio = 1.62; 95% CI 1.01 to 2.59). Late recurrence of AF happened in 35 (43%) of the 81 patients with early recurrence of AF, and in 35 (28%) of the 126 patients without early recurrence of AF. Conclusions: Early AF recurrence could predict late AF recurrence.

KW - Ablation

KW - Atrial fibrillation

KW - Radiofrequency

KW - Recurrence

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