Predictors of clinical progression in HIV-1-infected adults initiating combination antiretroviral therapy with advanced disease in the Asia-Pacific region: Results from the TREAT Asia HIV Observational Database

H. Byakwaga, K. Petoumenos, J. Ananworanich, F. Zhang, M. A. Boyd, T. Sirisanthana, P. C.K. Li, C. Lee, C. V. Mean, V. Saphonn, S. F.S. Omar, S. Pujari, P. Phanuphak, P. L. Lim, N. Kumarasamy, Y. M.A. Chen, T. P. Merati, S. Sungkanuparph, R. Ditangco, S. OkaG. Tau, J. Zhou, M. G. Law, S. Emery

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm3 in the TREAT Asia HIV Observational Database. The main outcome measure was progression to either an AIDS-defining illness or death occurring 6 months after initiation of cART. We used survival analysis methods. A total of 1255 patients contributed 2696 person years of follow-up; 73 were diagnosed with AIDS and 9 died. The rate of progression to the combined end point was 3.0 per 100 person years. The factors significantly associated with a higher risk of disease progression were Indian ethnicity, infection through intravenous drug use, lower CD4 count, and hemoglobin ≤130 g/dL at 6 months. In conclusion, measurements of CD4 count and hemoglobin at month 6 may be useful for early identification of disease progression in resource-limited settings.

Original languageEnglish
Pages (from-to)270-277
Number of pages8
JournalJournal of the International Association of Providers of AIDS Care
Volume12
Issue number4
DOIs
Publication statusPublished - Jul 1 2013
Externally publishedYes

Keywords

  • antiretroviral therapy
  • disease progression
  • HIV
  • resource-limited settings

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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    Byakwaga, H., Petoumenos, K., Ananworanich, J., Zhang, F., Boyd, M. A., Sirisanthana, T., Li, P. C. K., Lee, C., Mean, C. V., Saphonn, V., Omar, S. F. S., Pujari, S., Phanuphak, P., Lim, P. L., Kumarasamy, N., Chen, Y. M. A., Merati, T. P., Sungkanuparph, S., Ditangco, R., ... Emery, S. (2013). Predictors of clinical progression in HIV-1-infected adults initiating combination antiretroviral therapy with advanced disease in the Asia-Pacific region: Results from the TREAT Asia HIV Observational Database. Journal of the International Association of Providers of AIDS Care, 12(4), 270-277. https://doi.org/10.1177/1545109712469684