Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents

Jen Yu Wang, Yen Lin Chen, Chun Hsien Hsu, Sai Hung Tang, Chung Ze Wu, Dee Pei

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Abstract

Objective: To evaluate the cause-effect relationships between serum levels of uric acid (UA) and metabolic syndrome (MetS) in an adolescent-male cohort that was followed for 2.7 years. Study design: We enrolled male adolescents aged between 10 and 15 years at the baseline. A total of 613 subjects were divided into quartiles according to their UA levels, from UA-1 (the lowest) to UA-4 (the highest). Results: After the mean follow-up period of 2.7 ± 0.97 years, 19 (3.1%) subjects developed MetS. Waist circumference (WC), systolic blood pressure, high density lipoprotein cholesterol (HDL-C), and log triglyceride levels were significantly related to baseline UA levels. Compared with the UA-1 group, subjects in the UA-4 group had significantly higher OR for abnormal WC, blood pressure, and HDL-C at the end of follow-up and had a 6.39-fold higher OR (95% CI 1.41-29.08; P 7.6 mg/dL had a 4.32 (95% CI 1.57-11.93) higher risk of developing MetS. Conclusions: In this longitudinal study, we found that serum UA is correlated with future WC, systolic blood pressure, triglyceride, and HDL-C and is a risk factor for developing MetS. UA might be valuable in predicting adolescent MetS.

Original languageEnglish
JournalJournal of Pediatrics
Volume161
Issue number4
DOIs
Publication statusPublished - Oct 2012

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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