Predictive value of serum apolipoprotein B/apolipoprotein A-I ratio in metabolic syndrome risk: a Chinese cohort study

Yu Ching Chou, Jen Chun Kuan, Chyi-Huey Bai, Tsan Yang, Wan Yun Chou, Po Chien Hsieh, San Lin You, Lee Ching Hwang, Chien Hua Chen, Cheng Yu Wei, Chien An Sun

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate whether the apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio is a promising risk predictor of metabolic syndrome (MetS) and to determine the optimal cut-off value of this ratio in detecting subjects with MetS in a Chinese population. A prospective study was conducted using a representative sample of non-institutionized people in Taiwan. A total of 3,343 participants with mean age (±SD) of 39.86 (±15.61) years old were followed up from 2002 to 2007. The primary outcome was the incidence of MetS. The MetS was defined according to a unified criterion established by several major organizations. There were 462 cases of incident MetS during a mean follow-up period of 5.26 years. A significantly stepwise increase in the incidence of MetS across quartiles of the apoB/apoA-I ratio was noted in both sexes after adjustment for potential confounders (p for trend

Original languageEnglish
Pages (from-to)404-414
Number of pages11
JournalEndocrine
Volume49
Issue number2
DOIs
Publication statusPublished - Oct 12 2014

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Apolipoprotein A-I
Apolipoproteins B
Cohort Studies
Serum
Incidence
Taiwan
Prospective Studies
Population

Keywords

  • Apolipoprotein B/apolipoprotein A-I ratio
  • Cohort study
  • Metabolic syndrome
  • Risk predictor

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Predictive value of serum apolipoprotein B/apolipoprotein A-I ratio in metabolic syndrome risk : a Chinese cohort study. / Chou, Yu Ching; Kuan, Jen Chun; Bai, Chyi-Huey; Yang, Tsan; Chou, Wan Yun; Hsieh, Po Chien; You, San Lin; Hwang, Lee Ching; Chen, Chien Hua; Wei, Cheng Yu; Sun, Chien An.

In: Endocrine, Vol. 49, No. 2, 12.10.2014, p. 404-414.

Research output: Contribution to journalArticle

Chou, YC, Kuan, JC, Bai, C-H, Yang, T, Chou, WY, Hsieh, PC, You, SL, Hwang, LC, Chen, CH, Wei, CY & Sun, CA 2014, 'Predictive value of serum apolipoprotein B/apolipoprotein A-I ratio in metabolic syndrome risk: a Chinese cohort study', Endocrine, vol. 49, no. 2, pp. 404-414. https://doi.org/10.1007/s12020-014-0447-z
Chou, Yu Ching ; Kuan, Jen Chun ; Bai, Chyi-Huey ; Yang, Tsan ; Chou, Wan Yun ; Hsieh, Po Chien ; You, San Lin ; Hwang, Lee Ching ; Chen, Chien Hua ; Wei, Cheng Yu ; Sun, Chien An. / Predictive value of serum apolipoprotein B/apolipoprotein A-I ratio in metabolic syndrome risk : a Chinese cohort study. In: Endocrine. 2014 ; Vol. 49, No. 2. pp. 404-414.
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