Prediction of vascular dementia and Alzheimer's disease in patients with atrial fibrillation or atrial flutter using CHADS2 score

Ruey Hsing Chou, Chun Chih Chiu, Chin Chou Huang, Wan Leong Chan, Po Hsun Huang, Yu Chun Chen, Tzeng Ji Chen, Chia Min Chung, Shing Jong Lin, Jaw Wen Chen, Hsin Bang Leu

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9 Citations (Scopus)


Background Atrial fibrillation (AF) is associated with an increased risk of dementia. However, limited data are available on the predictors of dementia in patients with AF. This study aimed to evaluate whether the CHADS2 score could be a useful tool for risk stratification with regard to dementia occurrence among patients with AF. Methods AF patients were identified from the National Health Insurance sampling database, which has accumulated a total of 1,000,000 participants since 2000. After excluding patients diagnosed with dementia prior to the index day of enrollment, CHADS2 score was measured to investigate its association with the occurrence of dementia, including vascular dementia and Alzheimer's disease. Results During the mean follow-up period of 3.71 ± 2.78 years, 1135 dementia cases (7.36%) were identified, including 241 cases of vascular dementia and 894 cases of Alzheimer's disease. In multivariate analysis, an increase of 1 point in the CHADS2 score was independently associated with a 54% increase in the risk of vascular dementia (hazard ratio = 1.54; 95% confidence interval, 1.41–1.69; p < 0.001) and a 40% increase in Alzheimer's disease (hazard ratio = 1.40; 95% confidence interval, 1.34–1.46; p < 0.001). Conclusion CHADS2 score is a useful predictor for the development of vascular dementia as well as Alzheimer's disease in patients with AF.

Original languageEnglish
Pages (from-to)470-476
Number of pages7
JournalJournal of the Chinese Medical Association
Issue number9
Publication statusPublished - Sep 1 2016
Externally publishedYes


  • Alzheimer's disease
  • atrial fibrillation
  • CHADS2 score
  • dementia
  • stroke

ASJC Scopus subject areas

  • Medicine(all)


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