Prediction of the risk of hepatic failure in patients with portal vein invasion hepatoma after hepatic resection

C. B. Hsieh, C. Y. Yu, C. Tzao, H. C. Chu, T. W. Chen, H. F. Hsieh, Y. C. Liu, J. C. Yu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Aim: Hepatic failure can develop after curative hepatectomy in patients with a hepatocellular carcinoma (HCC) invading the portal vein, because of cirrhosis and excessive tissue loss. This study aimed to identify the risk factors for hepatic failure in such patients. Method: Forty patients with an HCC invading the portal vein underwent curative hepatectomy from January 1995 to June 2003. Eight patients developed hepatic failure and died within 3 months. Possible risk factors for this were analysed using univariate and multivariate regression. These included the liver function index, surgical blood loss, tumour pattern, portal hypertension, estimated residual liver volume measured by computed tomography (ERLVCT) and estimated residual liver volume using the indocyanine green (ICG) retention rate at 15 min (ERLVICG15). Results: The ERLVCT smaller than the ERLVICG15 and presence of portal hypertension were independent risk factors for post-hepatectomy hepatic failure. Conclusion: Having portal vein invasion HCC with portal hypertension or an ERLVCT less than an ERLVICG15 are significant predictors of post-hepatectomy hepatic failure. These factors are important considerations for patients with portal vein invasion HCC who could undergo curative hepatic resection.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalEuropean Journal of Surgical Oncology
Volume32
Issue number1
DOIs
Publication statusPublished - Feb 2006
Externally publishedYes

Fingerprint

Liver Failure
Portal Vein
Hepatocellular Carcinoma
Residual Volume
Hepatectomy
Cone-Beam Computed Tomography
Liver
Portal Hypertension
Surgical Blood Loss
Indocyanine Green
Fibrosis
Neoplasms

Keywords

  • Hepatocellular carcinoma
  • Portal vein invasion
  • Post-hepatectomy hepatic failure
  • Prediction
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Prediction of the risk of hepatic failure in patients with portal vein invasion hepatoma after hepatic resection. / Hsieh, C. B.; Yu, C. Y.; Tzao, C.; Chu, H. C.; Chen, T. W.; Hsieh, H. F.; Liu, Y. C.; Yu, J. C.

In: European Journal of Surgical Oncology, Vol. 32, No. 1, 02.2006, p. 72-76.

Research output: Contribution to journalArticle

Hsieh, C. B. ; Yu, C. Y. ; Tzao, C. ; Chu, H. C. ; Chen, T. W. ; Hsieh, H. F. ; Liu, Y. C. ; Yu, J. C. / Prediction of the risk of hepatic failure in patients with portal vein invasion hepatoma after hepatic resection. In: European Journal of Surgical Oncology. 2006 ; Vol. 32, No. 1. pp. 72-76.
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