Prediction of dry weight through changes in blood volume and plasma cyclic 3',5'-guanosine monophosphate in patients under maintenance hemodialysis

Guo Liang Wann, Chien Sung Tsai, Shih H. Lin, Woei D. Huang, Pauling Chu, Giien Shuen Chen, Yuh Feng Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dry weight evaluation is generally made from clinical observation of body weight (BW) changes, edema, blood pressure, and chest radiograph. In fact, 25-50% of patients on chronic hemodialysis had an incorrectly determined dry weight. To predict dry weight, twenty stable patients on regular hemodialysis were enrolled to investigate the correlation among dry weight, hematocrit, blood volume (BV), and vasoactive hormones including plasma renin activity (PRA), aldosterone (PA), and cyclic 3',5'-guanosine monophosphate (cGMP) values. BV was estimated by an infrared light reflection method. PRA, PA, and plasma cGMP were determined by commercial radioimmunoassay kits. The results showed significantly decreasing plasma cGMP values toward the end of hemodialysis compared with before hemodialysis (15.76 ± 3.56 pmol/ml vs 33.57 ± 3.98 pmol/ml; p <0.05). A significant correlation exists between changes in plasma cGMP values and BV (p <0.05). In addition, no significant correlation exists between changes in plasma cGMP and BW. A good correlation was found between changes in BV and hematocrit throughout dialysis (r = -0.774; p <0.001). PRA and PA values predict neither BV nor BW changes. All patients were treated to attain a further ultrafiltration of 0.5 to 1.0 L after reaching dry weight, and we found that the critical point in blood pressure drop occurred when BV decreased by 8% or when plasma cGMP values decreased by 50% from their initial values. Continuous BV monitoring with infrared light reflection and detecting of cGMP throughout hemodialysis could help predict dry weight and avoid dialysis hypotension.

Original languageEnglish
JournalASAIO Journal
Volume44
Issue number5
Publication statusPublished - Sep 1998
Externally publishedYes

Fingerprint

Plasma Volume
Cyclic GMP
Blood Volume
Renal Dialysis
Blood
Maintenance
Plasmas
Weights and Measures
Aldosterone
Renin
Light reflection
Body Weight Changes
Dialysis
Blood pressure
Hematocrit
Blood Pressure
Infrared radiation
Light
Hormones
Ultrafiltration

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Prediction of dry weight through changes in blood volume and plasma cyclic 3',5'-guanosine monophosphate in patients under maintenance hemodialysis. / Wann, Guo Liang; Tsai, Chien Sung; Lin, Shih H.; Huang, Woei D.; Chu, Pauling; Chen, Giien Shuen; Lin, Yuh Feng.

In: ASAIO Journal, Vol. 44, No. 5, 09.1998.

Research output: Contribution to journalArticle

Wann, Guo Liang ; Tsai, Chien Sung ; Lin, Shih H. ; Huang, Woei D. ; Chu, Pauling ; Chen, Giien Shuen ; Lin, Yuh Feng. / Prediction of dry weight through changes in blood volume and plasma cyclic 3',5'-guanosine monophosphate in patients under maintenance hemodialysis. In: ASAIO Journal. 1998 ; Vol. 44, No. 5.
@article{d9cc3c6af77b455180eff82373249e3c,
title = "Prediction of dry weight through changes in blood volume and plasma cyclic 3',5'-guanosine monophosphate in patients under maintenance hemodialysis",
abstract = "Dry weight evaluation is generally made from clinical observation of body weight (BW) changes, edema, blood pressure, and chest radiograph. In fact, 25-50{\%} of patients on chronic hemodialysis had an incorrectly determined dry weight. To predict dry weight, twenty stable patients on regular hemodialysis were enrolled to investigate the correlation among dry weight, hematocrit, blood volume (BV), and vasoactive hormones including plasma renin activity (PRA), aldosterone (PA), and cyclic 3',5'-guanosine monophosphate (cGMP) values. BV was estimated by an infrared light reflection method. PRA, PA, and plasma cGMP were determined by commercial radioimmunoassay kits. The results showed significantly decreasing plasma cGMP values toward the end of hemodialysis compared with before hemodialysis (15.76 ± 3.56 pmol/ml vs 33.57 ± 3.98 pmol/ml; p <0.05). A significant correlation exists between changes in plasma cGMP values and BV (p <0.05). In addition, no significant correlation exists between changes in plasma cGMP and BW. A good correlation was found between changes in BV and hematocrit throughout dialysis (r = -0.774; p <0.001). PRA and PA values predict neither BV nor BW changes. All patients were treated to attain a further ultrafiltration of 0.5 to 1.0 L after reaching dry weight, and we found that the critical point in blood pressure drop occurred when BV decreased by 8{\%} or when plasma cGMP values decreased by 50{\%} from their initial values. Continuous BV monitoring with infrared light reflection and detecting of cGMP throughout hemodialysis could help predict dry weight and avoid dialysis hypotension.",
author = "Wann, {Guo Liang} and Tsai, {Chien Sung} and Lin, {Shih H.} and Huang, {Woei D.} and Pauling Chu and Chen, {Giien Shuen} and Lin, {Yuh Feng}",
year = "1998",
month = "9",
language = "English",
volume = "44",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Prediction of dry weight through changes in blood volume and plasma cyclic 3',5'-guanosine monophosphate in patients under maintenance hemodialysis

AU - Wann, Guo Liang

AU - Tsai, Chien Sung

AU - Lin, Shih H.

AU - Huang, Woei D.

AU - Chu, Pauling

AU - Chen, Giien Shuen

AU - Lin, Yuh Feng

PY - 1998/9

Y1 - 1998/9

N2 - Dry weight evaluation is generally made from clinical observation of body weight (BW) changes, edema, blood pressure, and chest radiograph. In fact, 25-50% of patients on chronic hemodialysis had an incorrectly determined dry weight. To predict dry weight, twenty stable patients on regular hemodialysis were enrolled to investigate the correlation among dry weight, hematocrit, blood volume (BV), and vasoactive hormones including plasma renin activity (PRA), aldosterone (PA), and cyclic 3',5'-guanosine monophosphate (cGMP) values. BV was estimated by an infrared light reflection method. PRA, PA, and plasma cGMP were determined by commercial radioimmunoassay kits. The results showed significantly decreasing plasma cGMP values toward the end of hemodialysis compared with before hemodialysis (15.76 ± 3.56 pmol/ml vs 33.57 ± 3.98 pmol/ml; p <0.05). A significant correlation exists between changes in plasma cGMP values and BV (p <0.05). In addition, no significant correlation exists between changes in plasma cGMP and BW. A good correlation was found between changes in BV and hematocrit throughout dialysis (r = -0.774; p <0.001). PRA and PA values predict neither BV nor BW changes. All patients were treated to attain a further ultrafiltration of 0.5 to 1.0 L after reaching dry weight, and we found that the critical point in blood pressure drop occurred when BV decreased by 8% or when plasma cGMP values decreased by 50% from their initial values. Continuous BV monitoring with infrared light reflection and detecting of cGMP throughout hemodialysis could help predict dry weight and avoid dialysis hypotension.

AB - Dry weight evaluation is generally made from clinical observation of body weight (BW) changes, edema, blood pressure, and chest radiograph. In fact, 25-50% of patients on chronic hemodialysis had an incorrectly determined dry weight. To predict dry weight, twenty stable patients on regular hemodialysis were enrolled to investigate the correlation among dry weight, hematocrit, blood volume (BV), and vasoactive hormones including plasma renin activity (PRA), aldosterone (PA), and cyclic 3',5'-guanosine monophosphate (cGMP) values. BV was estimated by an infrared light reflection method. PRA, PA, and plasma cGMP were determined by commercial radioimmunoassay kits. The results showed significantly decreasing plasma cGMP values toward the end of hemodialysis compared with before hemodialysis (15.76 ± 3.56 pmol/ml vs 33.57 ± 3.98 pmol/ml; p <0.05). A significant correlation exists between changes in plasma cGMP values and BV (p <0.05). In addition, no significant correlation exists between changes in plasma cGMP and BW. A good correlation was found between changes in BV and hematocrit throughout dialysis (r = -0.774; p <0.001). PRA and PA values predict neither BV nor BW changes. All patients were treated to attain a further ultrafiltration of 0.5 to 1.0 L after reaching dry weight, and we found that the critical point in blood pressure drop occurred when BV decreased by 8% or when plasma cGMP values decreased by 50% from their initial values. Continuous BV monitoring with infrared light reflection and detecting of cGMP throughout hemodialysis could help predict dry weight and avoid dialysis hypotension.

UR - http://www.scopus.com/inward/record.url?scp=0344505829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344505829&partnerID=8YFLogxK

M3 - Article

C2 - 9804497

AN - SCOPUS:0344505829

VL - 44

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 5

ER -