Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging

Li Chun Hsieh, John W. Chen, Li Ying Wang, Yuk Ming Tsang, Pei Wei Shueng, Li Jen Liao, Wu Chia Lo, Yu Chin Lin, Chien Fu Tseng, Ying Shiung Kuo, Jie Yang Jhuang, Hui Ju Tien, Hsueh Fen Juan, Chen Hsi Hsieh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To develop magnetic resonance imaging (MRI) indicators to predict trismus outcome for post-operative oral cavity cancer patients who received adjuvant intensity-modulated radiation therapy (IMRT), 22 patients with oral cancer treated with IMRT were studied over a two-year period. Signal abnormality scores (SA scores) were computed from Likert-type ratings of the abnormalities of nine masticator structures and compared with the Mann-Whitney U-test and Kruskal-Wallis one-way ANOVA test between groups. Seventeen patients (77.3%) experienced different degrees of trismus during the two-year follow-up period. The SA score correlated with the trismus grade (r = 0.52, p<0.005). Patients having progressive trismus had higher mean doses of radiation to multiple structures, including the masticator and lateral pterygoid muscles, and the parotid gland (p<0.05). In addition, this group also had higher SA-masticator muscle dose product at 6 months and SA scores at 12 months (p<0.05). At the optimum cut-off points of 0.38 for the propensity score, the sensitivity was 100% and the specificity was 93% for predicting the prognosis of the trismus patients. The SA score, as determined using MRI, can reflect the radiation injury and correlate to trismus severity. Together with the radiation dose, it could serve as a useful biomarker to predict the outcome and guide the management of trismus following radiation therapy.

Original languageEnglish
Article numbere92561
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 21 2014

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Trismus
Mouth Neoplasms
Radiotherapy
radiotherapy
Magnetic resonance
magnetic resonance imaging
prognosis
Magnetic Resonance Imaging
Imaging techniques
Dosimetry
Muscle
Radiation
Biomarkers
Analysis of variance (ANOVA)
dosage
radiation injury
parotid gland
muscles
Pterygoid Muscles
adjuvants

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. / Hsieh, Li Chun; Chen, John W.; Wang, Li Ying; Tsang, Yuk Ming; Shueng, Pei Wei; Liao, Li Jen; Lo, Wu Chia; Lin, Yu Chin; Tseng, Chien Fu; Kuo, Ying Shiung; Jhuang, Jie Yang; Tien, Hui Ju; Juan, Hsueh Fen; Hsieh, Chen Hsi.

In: PLoS One, Vol. 9, No. 3, e92561, 21.03.2014.

Research output: Contribution to journalArticle

Hsieh, LC, Chen, JW, Wang, LY, Tsang, YM, Shueng, PW, Liao, LJ, Lo, WC, Lin, YC, Tseng, CF, Kuo, YS, Jhuang, JY, Tien, HJ, Juan, HF & Hsieh, CH 2014, 'Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging', PLoS One, vol. 9, no. 3, e92561. https://doi.org/10.1371/journal.pone.0092561
Hsieh, Li Chun ; Chen, John W. ; Wang, Li Ying ; Tsang, Yuk Ming ; Shueng, Pei Wei ; Liao, Li Jen ; Lo, Wu Chia ; Lin, Yu Chin ; Tseng, Chien Fu ; Kuo, Ying Shiung ; Jhuang, Jie Yang ; Tien, Hui Ju ; Juan, Hsueh Fen ; Hsieh, Chen Hsi. / Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. In: PLoS One. 2014 ; Vol. 9, No. 3.
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