Predicting short-term disease progression among HIV-infected patients in Asia and the Pacific region: Preliminary results from the TREAT Asia HIV Observational Database (TAHOD)

Julian Zhou, N. Kumarasamy, F. Zhang, H. Zhao, N. Han, P. Li, M. P. Lee, Y. M.A. Chen, W. W. Wong, D. C.C. Wang, S. Anand, J. A. Cecelia, S. Pujari, K. Joshi, C. K.C. Lee, S. Kaur, A. Kamarulzaman, R. Ditangco, R. Capistrano, N. I. PatonM. Yap, P. Phanuphak, U. Siangphe, M. Khongphattanayothing, A. Vibhagool, S. Kiertiburanakul, W. Kiatatchasai, J. Chuah, W. Fankhauser, B. Dickson, K. Frost, S. Wong, D. A. Cooper, M. G. Law, K. Petoumenos

Research output: Contribution to journalArticle

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Abstract

Objectives: HIV disease progression has been well documented in Western populations. This study aimed to estimate the short-term risk of AIDS and death from the TREAT Asia HIV Observational Database (TAHOD), a prospective, multicentre cohort study in Asia and the Pacific region. Methods: Prospective data were analysed to estimate short-term disease progression. Endpoints were defined as the time from study entry to diagnosis with AIDS or death. Antiretroviral treatment was fitted as a time-dependent variable. Predictors of disease progression were assessed using Cox proportional hazards models, and prognostic models were developed using Weibull models. Results: A total of 1260 patients with prospective follow-up data contributed 477 person-years of follow-up, during which 18 patients died and 34 were diagnosed with AIDS, a combined rate of 10.1 per 100 person-years. Compared with patients receiving antiretroviral treatment, patients not on treatment had a higher rate of disease progression (17.6 vs. 8.1 per 100 person-years, respectively). Baseline CD4 count was the strongest predictor of disease progression. Prognostic models, using either a baseline CD4 count as the sole marker or markers including baseline haemoglobin, AIDS-related symptoms and previous or current antiretroviral treatment, were successful at identifying patients at high risk of short-term disease progression. Conclusions: Similar to the situation in Western countries, baseline CD4 count was the strongest predictor of short-term disease progression. Prognostic models based on readily available clinical data and haemoglobin level should be useful in estimating short-term clinical risk in HIV-infected patients in Asia and the Pacific region.

Original languageEnglish
Pages (from-to)216-223
Number of pages8
JournalHIV Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - May 1 2005
Externally publishedYes

Fingerprint

Disease Progression
HIV
Databases
Acquired Immunodeficiency Syndrome
CD4 Lymphocyte Count
Hemoglobins
Time and Motion Studies
Therapeutics
Proportional Hazards Models
Multicenter Studies
Cohort Studies
Population

Keywords

  • AIDS
  • Disease progression
  • HIV
  • Observational Database

ASJC Scopus subject areas

  • Health Policy
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Predicting short-term disease progression among HIV-infected patients in Asia and the Pacific region : Preliminary results from the TREAT Asia HIV Observational Database (TAHOD). / Zhou, Julian; Kumarasamy, N.; Zhang, F.; Zhao, H.; Han, N.; Li, P.; Lee, M. P.; Chen, Y. M.A.; Wong, W. W.; Wang, D. C.C.; Anand, S.; Cecelia, J. A.; Pujari, S.; Joshi, K.; Lee, C. K.C.; Kaur, S.; Kamarulzaman, A.; Ditangco, R.; Capistrano, R.; Paton, N. I.; Yap, M.; Phanuphak, P.; Siangphe, U.; Khongphattanayothing, M.; Vibhagool, A.; Kiertiburanakul, S.; Kiatatchasai, W.; Chuah, J.; Fankhauser, W.; Dickson, B.; Frost, K.; Wong, S.; Cooper, D. A.; Law, M. G.; Petoumenos, K.

In: HIV Medicine, Vol. 6, No. 3, 01.05.2005, p. 216-223.

Research output: Contribution to journalArticle

Zhou, J, Kumarasamy, N, Zhang, F, Zhao, H, Han, N, Li, P, Lee, MP, Chen, YMA, Wong, WW, Wang, DCC, Anand, S, Cecelia, JA, Pujari, S, Joshi, K, Lee, CKC, Kaur, S, Kamarulzaman, A, Ditangco, R, Capistrano, R, Paton, NI, Yap, M, Phanuphak, P, Siangphe, U, Khongphattanayothing, M, Vibhagool, A, Kiertiburanakul, S, Kiatatchasai, W, Chuah, J, Fankhauser, W, Dickson, B, Frost, K, Wong, S, Cooper, DA, Law, MG & Petoumenos, K 2005, 'Predicting short-term disease progression among HIV-infected patients in Asia and the Pacific region: Preliminary results from the TREAT Asia HIV Observational Database (TAHOD)', HIV Medicine, vol. 6, no. 3, pp. 216-223. https://doi.org/10.1111/j.1468-1293.2005.00292.x
Zhou, Julian ; Kumarasamy, N. ; Zhang, F. ; Zhao, H. ; Han, N. ; Li, P. ; Lee, M. P. ; Chen, Y. M.A. ; Wong, W. W. ; Wang, D. C.C. ; Anand, S. ; Cecelia, J. A. ; Pujari, S. ; Joshi, K. ; Lee, C. K.C. ; Kaur, S. ; Kamarulzaman, A. ; Ditangco, R. ; Capistrano, R. ; Paton, N. I. ; Yap, M. ; Phanuphak, P. ; Siangphe, U. ; Khongphattanayothing, M. ; Vibhagool, A. ; Kiertiburanakul, S. ; Kiatatchasai, W. ; Chuah, J. ; Fankhauser, W. ; Dickson, B. ; Frost, K. ; Wong, S. ; Cooper, D. A. ; Law, M. G. ; Petoumenos, K. / Predicting short-term disease progression among HIV-infected patients in Asia and the Pacific region : Preliminary results from the TREAT Asia HIV Observational Database (TAHOD). In: HIV Medicine. 2005 ; Vol. 6, No. 3. pp. 216-223.
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abstract = "Objectives: HIV disease progression has been well documented in Western populations. This study aimed to estimate the short-term risk of AIDS and death from the TREAT Asia HIV Observational Database (TAHOD), a prospective, multicentre cohort study in Asia and the Pacific region. Methods: Prospective data were analysed to estimate short-term disease progression. Endpoints were defined as the time from study entry to diagnosis with AIDS or death. Antiretroviral treatment was fitted as a time-dependent variable. Predictors of disease progression were assessed using Cox proportional hazards models, and prognostic models were developed using Weibull models. Results: A total of 1260 patients with prospective follow-up data contributed 477 person-years of follow-up, during which 18 patients died and 34 were diagnosed with AIDS, a combined rate of 10.1 per 100 person-years. Compared with patients receiving antiretroviral treatment, patients not on treatment had a higher rate of disease progression (17.6 vs. 8.1 per 100 person-years, respectively). Baseline CD4 count was the strongest predictor of disease progression. Prognostic models, using either a baseline CD4 count as the sole marker or markers including baseline haemoglobin, AIDS-related symptoms and previous or current antiretroviral treatment, were successful at identifying patients at high risk of short-term disease progression. Conclusions: Similar to the situation in Western countries, baseline CD4 count was the strongest predictor of short-term disease progression. Prognostic models based on readily available clinical data and haemoglobin level should be useful in estimating short-term clinical risk in HIV-infected patients in Asia and the Pacific region.",
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T2 - Preliminary results from the TREAT Asia HIV Observational Database (TAHOD)

AU - Zhou, Julian

AU - Kumarasamy, N.

AU - Zhang, F.

AU - Zhao, H.

AU - Han, N.

AU - Li, P.

AU - Lee, M. P.

AU - Chen, Y. M.A.

AU - Wong, W. W.

AU - Wang, D. C.C.

AU - Anand, S.

AU - Cecelia, J. A.

AU - Pujari, S.

AU - Joshi, K.

AU - Lee, C. K.C.

AU - Kaur, S.

AU - Kamarulzaman, A.

AU - Ditangco, R.

AU - Capistrano, R.

AU - Paton, N. I.

AU - Yap, M.

AU - Phanuphak, P.

AU - Siangphe, U.

AU - Khongphattanayothing, M.

AU - Vibhagool, A.

AU - Kiertiburanakul, S.

AU - Kiatatchasai, W.

AU - Chuah, J.

AU - Fankhauser, W.

AU - Dickson, B.

AU - Frost, K.

AU - Wong, S.

AU - Cooper, D. A.

AU - Law, M. G.

AU - Petoumenos, K.

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N2 - Objectives: HIV disease progression has been well documented in Western populations. This study aimed to estimate the short-term risk of AIDS and death from the TREAT Asia HIV Observational Database (TAHOD), a prospective, multicentre cohort study in Asia and the Pacific region. Methods: Prospective data were analysed to estimate short-term disease progression. Endpoints were defined as the time from study entry to diagnosis with AIDS or death. Antiretroviral treatment was fitted as a time-dependent variable. Predictors of disease progression were assessed using Cox proportional hazards models, and prognostic models were developed using Weibull models. Results: A total of 1260 patients with prospective follow-up data contributed 477 person-years of follow-up, during which 18 patients died and 34 were diagnosed with AIDS, a combined rate of 10.1 per 100 person-years. Compared with patients receiving antiretroviral treatment, patients not on treatment had a higher rate of disease progression (17.6 vs. 8.1 per 100 person-years, respectively). Baseline CD4 count was the strongest predictor of disease progression. Prognostic models, using either a baseline CD4 count as the sole marker or markers including baseline haemoglobin, AIDS-related symptoms and previous or current antiretroviral treatment, were successful at identifying patients at high risk of short-term disease progression. Conclusions: Similar to the situation in Western countries, baseline CD4 count was the strongest predictor of short-term disease progression. Prognostic models based on readily available clinical data and haemoglobin level should be useful in estimating short-term clinical risk in HIV-infected patients in Asia and the Pacific region.

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KW - Disease progression

KW - HIV

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