Predication the suppressing human oral cancer cell line by curcumin through the research of fas receptor

Po Yuan Chen, Yu Chi Wu, Tzu Hurng Cheng, Tzu Ching Shih, Cing Tsan Tsai, Chieh Hsi Wu, Tzu Yu Hua, Yen Yu Huang, Chia Hsing Cheng, Ming Jen Fan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Curcumin is commonly applied as food coloring and seasoning but recent research show that curcumin is able to enhance the activation of Fas receptor to the cancer cell apoptosis through extrinsic pathway. Oral cancer results from the particular habit of chewing betel nuts that Taiwanese have. The additive in betel nuts (such as lime) is the main reason that increase the cancer rate of people chewing betel nuts and further increase the death rate gradually. The major treatments for oral cancer are still chemotherapy and surgery. This research expects to perform the computer simulation to calculate the activity of curcumin to oral cancer as medicine. The pharmaceutical activity are evaluate by the score from docking procedure perform by simulation program. We hope this experiment can be the evidence that curcumin can practically be used as medicine for oral cancer therapy in future.

Original languageEnglish
Title of host publicationProceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
Pages209-212
Number of pages4
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 - Taichung, Taiwan
Duration: Oct 24 2011Oct 26 2011

Other

Other2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011
CountryTaiwan
CityTaichung
Period10/24/1110/26/11

Keywords

  • cell apoptosis
  • curcumin
  • docking
  • Fas receptor
  • oral cancer

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Chen, P. Y., Wu, Y. C., Cheng, T. H., Shih, T. C., Tsai, C. T., Wu, C. H., Hua, T. Y., Huang, Y. Y., Cheng, C. H., & Fan, M. J. (2011). Predication the suppressing human oral cancer cell line by curcumin through the research of fas receptor. In Proceedings - 2011 11th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2011 (pp. 209-212). [6092531] https://doi.org/10.1109/BIBE.2011.68