Predialysis glycemic control is an independent predictor of clinical outcome in type II diabetics on continuous ambulatory peritoneal dialysis

Chun Chen Yu, Mai Szu Wu, Ching Herng Wu, Chih Wei Yang, Jeng Yi Huang, Jenn Jye Hong, Chun Yi Fan Chiang, Mei Ling Leu, Chiu Ching Huang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To evaluate the correlation between predialysis glycemic control and clinical outcomes for type II diabetic patients on continuous ambulatory peritoneal dialysis (CAPD). Design: Sixty type II diabetic patients on CAPD were classified into 2 groups according to the status of glycemic control. In group G (good glycemic control), more than 50% of blood glucose determinations were within 3.3-11 mmol/L and the glycosylated hemoglobin (HbA1C) level was within 5-10% at all times. In group P (poor glycemic control), fewer than 50% of blood glucose determinations were within 3.3-11 mmol/L or HbA1C level was above 10% at least once during the follow-up duration. In addition to glycemic control status, predialysis serum albumin, cholesterol levels, residual renal function, peritoneal membrane function, and the modes of glycemic control were also recorded. Setting: Dialysis Unit, Department of Nephrology of a single university hospital. Patients: From February 1988 to October 1995, 60 type II diabetic patients receiving CAPD for at least 3 months were enrolled. Main Outcome Measures: Morbidities before and during the dialysis period, patient survival, and causes of mortality. Results: The patients with good glycemic control had significantly better survival than patients with poor glycemic control (p <0.01). There was no significant difference in predialysis morbidity between the two groups. No significant differences were observed in patient survival between the patients with serum albumin greater than 30 g/L and those with less than 30 g/L (p = 0.77), with cholesterol levels greater or less than 5.18 mmol/L (p = 0.73), and with different peritoneal membrane solute transport characteristics evaluated by peritoneal equilibration test (p = 0.12). Furthermore, there was no significant difference in survival whether the patients controlled blood sugar by diet or with insulin (p = 0.33). Cardiovascular disease and infection were the major causes of death in both groups. Although good glycemic control predicts better survival, it does not change the pattern of mortality in diabetics maintained on CAPD. Conclusions: Glycemic control before starting dialysis is a predictor of survival for type II diabetics on CAPD. Patients with poor glycemic control predialysis are associated with increased morbidity and shortened survival.

Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalPeritoneal Dialysis International
Volume17
Issue number3
Publication statusPublished - May 1997
Externally publishedYes

Fingerprint

Continuous Ambulatory Peritoneal Dialysis
Survival
Blood Glucose
Dialysis
Morbidity
Serum Albumin
Cardiovascular Infections
Cholesterol
Membranes
Nephrology
Mortality
Glycosylated Hemoglobin A
Cause of Death
Cardiovascular Diseases
Outcome Assessment (Health Care)
Insulin
Diet
Kidney

Keywords

  • Diabetes
  • Glycemic control

ASJC Scopus subject areas

  • Nephrology

Cite this

Predialysis glycemic control is an independent predictor of clinical outcome in type II diabetics on continuous ambulatory peritoneal dialysis. / Yu, Chun Chen; Wu, Mai Szu; Wu, Ching Herng; Yang, Chih Wei; Huang, Jeng Yi; Hong, Jenn Jye; Chiang, Chun Yi Fan; Leu, Mei Ling; Huang, Chiu Ching.

In: Peritoneal Dialysis International, Vol. 17, No. 3, 05.1997, p. 262-268.

Research output: Contribution to journalArticle

Yu, Chun Chen ; Wu, Mai Szu ; Wu, Ching Herng ; Yang, Chih Wei ; Huang, Jeng Yi ; Hong, Jenn Jye ; Chiang, Chun Yi Fan ; Leu, Mei Ling ; Huang, Chiu Ching. / Predialysis glycemic control is an independent predictor of clinical outcome in type II diabetics on continuous ambulatory peritoneal dialysis. In: Peritoneal Dialysis International. 1997 ; Vol. 17, No. 3. pp. 262-268.
@article{7a70a3cfa3f040039a044f17451734cc,
title = "Predialysis glycemic control is an independent predictor of clinical outcome in type II diabetics on continuous ambulatory peritoneal dialysis",
abstract = "Objective: To evaluate the correlation between predialysis glycemic control and clinical outcomes for type II diabetic patients on continuous ambulatory peritoneal dialysis (CAPD). Design: Sixty type II diabetic patients on CAPD were classified into 2 groups according to the status of glycemic control. In group G (good glycemic control), more than 50{\%} of blood glucose determinations were within 3.3-11 mmol/L and the glycosylated hemoglobin (HbA1C) level was within 5-10{\%} at all times. In group P (poor glycemic control), fewer than 50{\%} of blood glucose determinations were within 3.3-11 mmol/L or HbA1C level was above 10{\%} at least once during the follow-up duration. In addition to glycemic control status, predialysis serum albumin, cholesterol levels, residual renal function, peritoneal membrane function, and the modes of glycemic control were also recorded. Setting: Dialysis Unit, Department of Nephrology of a single university hospital. Patients: From February 1988 to October 1995, 60 type II diabetic patients receiving CAPD for at least 3 months were enrolled. Main Outcome Measures: Morbidities before and during the dialysis period, patient survival, and causes of mortality. Results: The patients with good glycemic control had significantly better survival than patients with poor glycemic control (p <0.01). There was no significant difference in predialysis morbidity between the two groups. No significant differences were observed in patient survival between the patients with serum albumin greater than 30 g/L and those with less than 30 g/L (p = 0.77), with cholesterol levels greater or less than 5.18 mmol/L (p = 0.73), and with different peritoneal membrane solute transport characteristics evaluated by peritoneal equilibration test (p = 0.12). Furthermore, there was no significant difference in survival whether the patients controlled blood sugar by diet or with insulin (p = 0.33). Cardiovascular disease and infection were the major causes of death in both groups. Although good glycemic control predicts better survival, it does not change the pattern of mortality in diabetics maintained on CAPD. Conclusions: Glycemic control before starting dialysis is a predictor of survival for type II diabetics on CAPD. Patients with poor glycemic control predialysis are associated with increased morbidity and shortened survival.",
keywords = "Diabetes, Glycemic control",
author = "Yu, {Chun Chen} and Wu, {Mai Szu} and Wu, {Ching Herng} and Yang, {Chih Wei} and Huang, {Jeng Yi} and Hong, {Jenn Jye} and Chiang, {Chun Yi Fan} and Leu, {Mei Ling} and Huang, {Chiu Ching}",
year = "1997",
month = "5",
language = "English",
volume = "17",
pages = "262--268",
journal = "Peritoneal Dialysis International",
issn = "0896-8608",
publisher = "Multimed Inc.",
number = "3",

}

TY - JOUR

T1 - Predialysis glycemic control is an independent predictor of clinical outcome in type II diabetics on continuous ambulatory peritoneal dialysis

AU - Yu, Chun Chen

AU - Wu, Mai Szu

AU - Wu, Ching Herng

AU - Yang, Chih Wei

AU - Huang, Jeng Yi

AU - Hong, Jenn Jye

AU - Chiang, Chun Yi Fan

AU - Leu, Mei Ling

AU - Huang, Chiu Ching

PY - 1997/5

Y1 - 1997/5

N2 - Objective: To evaluate the correlation between predialysis glycemic control and clinical outcomes for type II diabetic patients on continuous ambulatory peritoneal dialysis (CAPD). Design: Sixty type II diabetic patients on CAPD were classified into 2 groups according to the status of glycemic control. In group G (good glycemic control), more than 50% of blood glucose determinations were within 3.3-11 mmol/L and the glycosylated hemoglobin (HbA1C) level was within 5-10% at all times. In group P (poor glycemic control), fewer than 50% of blood glucose determinations were within 3.3-11 mmol/L or HbA1C level was above 10% at least once during the follow-up duration. In addition to glycemic control status, predialysis serum albumin, cholesterol levels, residual renal function, peritoneal membrane function, and the modes of glycemic control were also recorded. Setting: Dialysis Unit, Department of Nephrology of a single university hospital. Patients: From February 1988 to October 1995, 60 type II diabetic patients receiving CAPD for at least 3 months were enrolled. Main Outcome Measures: Morbidities before and during the dialysis period, patient survival, and causes of mortality. Results: The patients with good glycemic control had significantly better survival than patients with poor glycemic control (p <0.01). There was no significant difference in predialysis morbidity between the two groups. No significant differences were observed in patient survival between the patients with serum albumin greater than 30 g/L and those with less than 30 g/L (p = 0.77), with cholesterol levels greater or less than 5.18 mmol/L (p = 0.73), and with different peritoneal membrane solute transport characteristics evaluated by peritoneal equilibration test (p = 0.12). Furthermore, there was no significant difference in survival whether the patients controlled blood sugar by diet or with insulin (p = 0.33). Cardiovascular disease and infection were the major causes of death in both groups. Although good glycemic control predicts better survival, it does not change the pattern of mortality in diabetics maintained on CAPD. Conclusions: Glycemic control before starting dialysis is a predictor of survival for type II diabetics on CAPD. Patients with poor glycemic control predialysis are associated with increased morbidity and shortened survival.

AB - Objective: To evaluate the correlation between predialysis glycemic control and clinical outcomes for type II diabetic patients on continuous ambulatory peritoneal dialysis (CAPD). Design: Sixty type II diabetic patients on CAPD were classified into 2 groups according to the status of glycemic control. In group G (good glycemic control), more than 50% of blood glucose determinations were within 3.3-11 mmol/L and the glycosylated hemoglobin (HbA1C) level was within 5-10% at all times. In group P (poor glycemic control), fewer than 50% of blood glucose determinations were within 3.3-11 mmol/L or HbA1C level was above 10% at least once during the follow-up duration. In addition to glycemic control status, predialysis serum albumin, cholesterol levels, residual renal function, peritoneal membrane function, and the modes of glycemic control were also recorded. Setting: Dialysis Unit, Department of Nephrology of a single university hospital. Patients: From February 1988 to October 1995, 60 type II diabetic patients receiving CAPD for at least 3 months were enrolled. Main Outcome Measures: Morbidities before and during the dialysis period, patient survival, and causes of mortality. Results: The patients with good glycemic control had significantly better survival than patients with poor glycemic control (p <0.01). There was no significant difference in predialysis morbidity between the two groups. No significant differences were observed in patient survival between the patients with serum albumin greater than 30 g/L and those with less than 30 g/L (p = 0.77), with cholesterol levels greater or less than 5.18 mmol/L (p = 0.73), and with different peritoneal membrane solute transport characteristics evaluated by peritoneal equilibration test (p = 0.12). Furthermore, there was no significant difference in survival whether the patients controlled blood sugar by diet or with insulin (p = 0.33). Cardiovascular disease and infection were the major causes of death in both groups. Although good glycemic control predicts better survival, it does not change the pattern of mortality in diabetics maintained on CAPD. Conclusions: Glycemic control before starting dialysis is a predictor of survival for type II diabetics on CAPD. Patients with poor glycemic control predialysis are associated with increased morbidity and shortened survival.

KW - Diabetes

KW - Glycemic control

UR - http://www.scopus.com/inward/record.url?scp=0030812652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030812652&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 262

EP - 268

JO - Peritoneal Dialysis International

JF - Peritoneal Dialysis International

SN - 0896-8608

IS - 3

ER -