Preconditioning threshold of brief pressure overload of the left ventricle

Fei Yi Wu, Chen Yuan Hsiao, Chih Pei Ou-Yang, Chang Chi Lai, Yi You Wang, Zen Chung Weng, Cheng Hsiung Huang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We previously reported that pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits. The threshold of pressure overload was investigated in this study. Methods: Pressure overload of the left ventricle was induced by partial snare of the ascending aorta in anesthetized, open-chest rabbits. Systolic left ventricular pressure (SLVP) was elevated 50% or 30% above baseline value by varying the degree of partial snaring. Different duration of pressure overload, including 10 minutes, 5 minutes, 3 minutes, or 2 minutes, was applied to determine the threshold of protective effects. Ischemic preconditioning was elicited by two 10-minute coronary artery occlusions and reperfusions. Ten minutes after different pretreatment, 1 hour occlusion of the left anterior descending coronary artery followed by 3 hours reperfusion was done to induce MI. The size of area at risk and MI were determined by blue dye injection and triphenyl tetrazolium chloride staining after experiments. Results: Pressure overload increase of SLVP 50% above baseline value for 10 minutes, 5 minutes, and 3 minutes significantly reduced MI size (18.5±3.6%, 21.4±1.9% and 21.6±1.7%, respectively, vs. 26.6±1.0% in the control group, mean±standard deviation, p

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalJournal of the Chinese Medical Association
Volume76
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Heart Ventricles
Pressure
Myocardial Infarction
Ventricular Pressure
Coronary Vessels
Rabbits
Ischemic Preconditioning
Myocardial Reperfusion
Coronary Occlusion
Reperfusion
Aorta
Chlorides
Coloring Agents
Thorax
Staining and Labeling
Control Groups
Injections

Keywords

  • Ischemic preconditioning
  • Left ventricular pressure overload
  • Myocardial infarction
  • Rabbits

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wu, F. Y., Hsiao, C. Y., Ou-Yang, C. P., Lai, C. C., Wang, Y. Y., Weng, Z. C., & Huang, C. H. (2013). Preconditioning threshold of brief pressure overload of the left ventricle. Journal of the Chinese Medical Association, 76(9), 497-503. https://doi.org/10.1016/j.jcma.2013.05.005

Preconditioning threshold of brief pressure overload of the left ventricle. / Wu, Fei Yi; Hsiao, Chen Yuan; Ou-Yang, Chih Pei; Lai, Chang Chi; Wang, Yi You; Weng, Zen Chung; Huang, Cheng Hsiung.

In: Journal of the Chinese Medical Association, Vol. 76, No. 9, 09.2013, p. 497-503.

Research output: Contribution to journalArticle

Wu, FY, Hsiao, CY, Ou-Yang, CP, Lai, CC, Wang, YY, Weng, ZC & Huang, CH 2013, 'Preconditioning threshold of brief pressure overload of the left ventricle', Journal of the Chinese Medical Association, vol. 76, no. 9, pp. 497-503. https://doi.org/10.1016/j.jcma.2013.05.005
Wu, Fei Yi ; Hsiao, Chen Yuan ; Ou-Yang, Chih Pei ; Lai, Chang Chi ; Wang, Yi You ; Weng, Zen Chung ; Huang, Cheng Hsiung. / Preconditioning threshold of brief pressure overload of the left ventricle. In: Journal of the Chinese Medical Association. 2013 ; Vol. 76, No. 9. pp. 497-503.
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