Preconditioning threshold of brief pressure overload of the left ventricle

Fei Yi Wu, Chen Yuan Hsiao, Chih Pei Ou-Yang, Chang Chi Lai, Yi You Wang, Zen Chung Weng, Cheng Hsiung Huang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We previously reported that pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits. The threshold of pressure overload was investigated in this study. Methods: Pressure overload of the left ventricle was induced by partial snare of the ascending aorta in anesthetized, open-chest rabbits. Systolic left ventricular pressure (SLVP) was elevated 50% or 30% above baseline value by varying the degree of partial snaring. Different duration of pressure overload, including 10 minutes, 5 minutes, 3 minutes, or 2 minutes, was applied to determine the threshold of protective effects. Ischemic preconditioning was elicited by two 10-minute coronary artery occlusions and reperfusions. Ten minutes after different pretreatment, 1 hour occlusion of the left anterior descending coronary artery followed by 3 hours reperfusion was done to induce MI. The size of area at risk and MI were determined by blue dye injection and triphenyl tetrazolium chloride staining after experiments. Results: Pressure overload increase of SLVP 50% above baseline value for 10 minutes, 5 minutes, and 3 minutes significantly reduced MI size (18.5±3.6%, 21.4±1.9% and 21.6±1.7%, respectively, vs. 26.6±1.0% in the control group, mean±standard deviation, p

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalJournal of the Chinese Medical Association
Volume76
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Ischemic preconditioning
  • Left ventricular pressure overload
  • Myocardial infarction
  • Rabbits

ASJC Scopus subject areas

  • Medicine(all)

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