Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells

Chia-Woei Wang, Chien Kai Wang, Yu Jia Chang, Chen Yen Choong, Chi Shian Lin, Cheng Jeng Tai, Chen Jei Tai

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8 Citations (Scopus)

Abstract

Fermented wheat germ extract (FWGE) is a nutrient supplement and a potential antitumor ingredient for developing an integrated chemotherapy with standard chemotherapeutic drugs for treating ovarian cancer patients. In this study, we evaluated the tumor suppression efficiency of FWGE in human ovarian carcinoma cells, SKOV-3 and ES-2, and found the half-maximal inhibitory concentrations (IC50s) to be 643.76 g/mL and 246.11 g/mL after 48 h of FWGE treatment. FWGE treatment also induced programmed cell death by activating the caspase-7 cleavage in both SKOV-3 and ES-2 cells, but only caspase-3 and poly(adenosine diphosphate-ribose) polymerase cleavages were activated in SKOV-3 cells. Moreover, FWGE exhibited combination drug effects with cisplatin and docetaxel in SKOV-3 and ES-2 cells by enhancing the cytotoxicity of both drugs. In conclusion, we found that FWGE not only suppressed cell growth but also induced caspase-3-related and caspase-7-related cell death in human ovarian carcinoma cells. FWGE treatment further enhanced the cytotoxicity of cisplatin and docetaxel, suggesting that FWGE is a potential ingredient in the development of adjuvant chemotherapy with cisplatin or docetaxel for treating ovarian cancer patients.

Original languageEnglish
Article number570785
JournalEvidence-based Complementary and Alternative Medicine
Volume2015
DOIs
Publication statusPublished - 2015

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Drug Combinations
docetaxel
Carcinoma
Neoplasms
Cisplatin
Caspase 7
Caspase 3
Ovarian Neoplasms
Cell Death
Poly Adenosine Diphosphate Ribose
Avemar
Adjuvant Chemotherapy
Pharmaceutical Preparations
Therapeutics
Drug Therapy
Food
Growth

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

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title = "Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells",
abstract = "Fermented wheat germ extract (FWGE) is a nutrient supplement and a potential antitumor ingredient for developing an integrated chemotherapy with standard chemotherapeutic drugs for treating ovarian cancer patients. In this study, we evaluated the tumor suppression efficiency of FWGE in human ovarian carcinoma cells, SKOV-3 and ES-2, and found the half-maximal inhibitory concentrations (IC50s) to be 643.76 g/mL and 246.11 g/mL after 48 h of FWGE treatment. FWGE treatment also induced programmed cell death by activating the caspase-7 cleavage in both SKOV-3 and ES-2 cells, but only caspase-3 and poly(adenosine diphosphate-ribose) polymerase cleavages were activated in SKOV-3 cells. Moreover, FWGE exhibited combination drug effects with cisplatin and docetaxel in SKOV-3 and ES-2 cells by enhancing the cytotoxicity of both drugs. In conclusion, we found that FWGE not only suppressed cell growth but also induced caspase-3-related and caspase-7-related cell death in human ovarian carcinoma cells. FWGE treatment further enhanced the cytotoxicity of cisplatin and docetaxel, suggesting that FWGE is a potential ingredient in the development of adjuvant chemotherapy with cisplatin or docetaxel for treating ovarian cancer patients.",
author = "Chia-Woei Wang and Wang, {Chien Kai} and Chang, {Yu Jia} and Choong, {Chen Yen} and Lin, {Chi Shian} and Tai, {Cheng Jeng} and Tai, {Chen Jei}",
year = "2015",
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AU - Wang, Chia-Woei

AU - Wang, Chien Kai

AU - Chang, Yu Jia

AU - Choong, Chen Yen

AU - Lin, Chi Shian

AU - Tai, Cheng Jeng

AU - Tai, Chen Jei

PY - 2015

Y1 - 2015

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