Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration

Ming Hwang Shyr, Chen Hsien Yang, Terry B.J. Kuo, Wynn H.T. Pan, Peter P.C. Tan, Samuel H.H. Chan

Research output: Contribution to journalArticle

21 Citations (Scopus)


Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that the minimal effective antinociceptive dose of propofol in adult, male Sprague-Dawley rats, given in an intravenous bolus manner, was 10 mg/kg. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant transient suppression of the EEG activity, primarily in the θ{symbol} and σ bands, alongside minor hypotensive and negative inotropic and chronotropic actions, but with maintained vasomotor tone. These alterations followed a time course that paralleled the plasma concentration of propofol in the arterial blood, as detected by high-performance liquid chromatography.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Issue number2
Publication statusPublished - Apr 30 1993
Externally publishedYes



  • Anesthesia
  • Electroencephalogram
  • Noxious thermal stimulation
  • Power spectral analysis
  • Propofol
  • Rat
  • Systemic arterial pressure

ASJC Scopus subject areas

  • Neuroscience(all)

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