Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat

T. Y. Lee, M. J. Fu, T. B.J. Kuo, P. W. Lui, S. H.H. Chan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have measured electromyographic (EMG) and systemic arterial pressure (SAP) signals during fentanyi-induced muscular rigidity in adult male Sprague-Dawley rats anaesthetized initially with ketamine 120 mg kg-1 i.p. during controlled ventilation. Fentanyl 100 μg kg-1 i.v. induced significant increase in EMG activity, recorded from the sacrococcygeus dorsi lateralis muscle. Power spectral analysis revealed that this was produced by an increase in the root mean square and a decrease in the mean power frequency values of the signals, signifying recruitment and synchronous activation of motor units. Together with transient hypotension and bradycardia, power spectral analysis of the SA P signals demonstrated a reduced but maintained power density of the frequency components that represent respiratory, baroreceptor and vasomotor activities. All these effects were only demonstrated unequivocally in rats maintained by i.v. infusion of ketamine until 10 min before the administration of fentanyl. We conclude that analysis of the temporal alterations in the spectral components of the EMG and SAP signals in rats during mechanical ventilation provides a sensitive method of measuring fentanyi-induced muscular rigidity and the accompanying alterations in haemodynamic variables. (Br. J. Anaesth. 1994; 72: 328-334)

Original languageEnglish
Pages (from-to)328-334
Number of pages7
JournalBritish Journal of Anaesthesia
Volume72
Issue number3
DOIs
Publication statusPublished - Mar 1994
Externally publishedYes

Fingerprint

Muscle Rigidity
Ketamine
Fentanyl
Arterial Pressure
Pressoreceptors
Bradycardia
Artificial Respiration
Hypotension
Sprague Dawley Rats
Ventilation
Hemodynamics
Muscles

Keywords

  • Anaesthetics, i. v.: ketamine
  • Analgesics, opioid: fentanyl
  • Complications: hypotension
  • Complications: muscular rigidity
  • Measurement techniques: arterial pressure
  • Measurement techniques: electromyography
  • Measurement techniques: spectral analysis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat. / Lee, T. Y.; Fu, M. J.; Kuo, T. B.J.; Lui, P. W.; Chan, S. H.H.

In: British Journal of Anaesthesia, Vol. 72, No. 3, 03.1994, p. 328-334.

Research output: Contribution to journalArticle

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