Power Doppler breast ultrasound: Association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma

Shou Tung Chen, Shou Jen Kuo, Hwa Koon Wu, Li Sheng Chen, Dar Ren Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Angiogenesis is a fundamental component of oncogenesis. In this study we provided morphologic evidence of vascularization by using power Doppler ultrasound to correlate the clinicopathologic features of tumorigenesis, ER/c-erbB-2 expression, and tumor grade in invasive breast carcinoma. Methods: Three indices (VI, vascularization index; FI, flow index; VFI, vascularization flow index) were used to analyze 3D power Doppler ultrasound images from 168 patients with malignant breast carcinoma and to correlate their clinicopathologic features. Results: VI (the mean tumor vascularity) was correlated with ER negativity (p <0.0029) and VFI (the overall perfusion) was correlated with ER positivity (p <0.0029). HER2 positivity was statistically significantly correlated with tumor vasculature (VI, VFI) and tumor size/volume. FI (the mean blood flow volume) was significantly correlated with tumor size/volume, but VI was not. The univariate or multivariate logistic regression analysis also showed the reverse correlations between ER expression and tumor vascularity, and positive correlations between HER2 expression and tumor vascularity as well as tumor volume. Conclusions: This morphologic evidence of vascularization is correlated with tumor angiogenesis and ER/c-erbB-2 co-expression, which could clarify the biology of breast cancer.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalBreast Cancer
Volume20
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Doppler Ultrasonography
Breast
Breast Neoplasms
Tumor Burden
Neoplasms
Carcinogenesis
Blood Volume
Perfusion
Logistic Models
Regression Analysis

Keywords

  • c-erbB-2
  • Estrogen receptor
  • Tumorigenesis
  • Vascularization

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Power Doppler breast ultrasound : Association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma. / Chen, Shou Tung; Kuo, Shou Jen; Wu, Hwa Koon; Chen, Li Sheng; Chen, Dar Ren.

In: Breast Cancer, Vol. 20, No. 2, 04.2013, p. 152-158.

Research output: Contribution to journalArticle

Chen, Shou Tung ; Kuo, Shou Jen ; Wu, Hwa Koon ; Chen, Li Sheng ; Chen, Dar Ren. / Power Doppler breast ultrasound : Association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma. In: Breast Cancer. 2013 ; Vol. 20, No. 2. pp. 152-158.
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