Abstract

Background: Curcumin is a polyphenol natural product of the plant Curcuma longa. Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment. Purpose: We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model. Study Design: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice. Methods: The novel object recognition test was used to analyze the recognition memory function. The long-term potentiation was studied using electrophysiological analysis. Western blotting was used to assess the protein expression and activation status. Results: Recognition memory deficit began as early as 4 weeks of age in both male and female Tsc2+/− mice. Oral administration with SLCP activates AMPK activity and inhibits mTOR activity in the brain tissue of Tsc2+/− mice, and can rescue the electrophysiological abnormality and object recognition memory loss in the mice. Conclusions: Our results suggest that SLCP could be an effective treatment for TSC patients.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalPhytomedicine
Volume54
DOIs
Publication statusPublished - Feb 15 2019

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Tuberous Sclerosis
Curcumin
Therapeutic Uses
Memory Disorders
Lipids
Curcuma
AMP-Activated Protein Kinases
Long-Term Potentiation
Polyphenols
Biological Products
Knockout Mice
Oral Administration
Therapeutics
Animal Models
Western Blotting
Recognition (Psychology)
Brain

Keywords

  • Curcumin
  • Solid lipid curcumin particle
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex. / Kuo, Chu Jen; Huang, Chi Chen; Chou, Szu Yi; Lo, Yu Chun; Kao, Tzu Jen; Huang, Nai Kuei; Lin, Connie; Lin, Hsin Chuan; Lin, Hui Ching; Lee, Yi Chao.

In: Phytomedicine, Vol. 54, 15.02.2019, p. 132-139.

Research output: Contribution to journalArticle

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AU - Huang, Nai Kuei

AU - Lin, Connie

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