Potential prognostic biomarkers of OSBPL family genes in patients with pancreatic ductal adenocarcinoma

Cheng Wei Chou, Yu Hsiu Hsieh, Su Chi Ku, Wan Jou Shen, Gangga Anuraga, Hoang Dang Khoa Ta, Kuen Haur Lee, Yu Cheng Lee, Cheng Hsien Lin, Chih Yang Wang, Wei Jan Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDAC and OSBPL family members have not comprehensively been elucidated. In this study, we used the Oncomine and GEPIA 2 databases to analyze OSBPL transcription expressions in PDAC. The Kaplan–Meier plotter and TIMER 2.0 were used to assess the relationships between overall survival (OS) and immune-infiltration with OSBPL family members. Co-expression data from cBioPortal were downloaded to assess the correlated pathways with OSBPL gene family members using DAVID. The expressions of OSBPL3, OSBPL8, OSBPL10, and OSBPL11 were found to be highly upregulated in PDAC. Low expressions of OSBPL3, OSBPL8, and OSBPL10 indicated longer OS. The functions of OSBPL family members were mainly associated with several potential signaling pathways in cancer cells, including ATP binding, integrin binding, receptor binding, and the renin-angiotensin system (RAS) signaling pathway. The transcription levels of OSBPL gene family members were connected with several immune infiltrates. Collectively, OSBPL family members are influential biomarkers for the early diagnosis of PDAC and have prognostic value, with the promise of precise treatment of PDAC in the future.

Original languageEnglish
Article number1601
JournalBiomedicines
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Biomarker
  • OSBPL10
  • OSBPL11
  • OSBPL2
  • OSBPL3
  • OSBPL5
  • OSBPL6
  • OSBPL7
  • OSBPL8
  • OSBPL9
  • Pancreatic ductal adenocarcinoma

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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