Potential of vitamin D in treating diabetic cardiomyopathy

Ting Wei Lee, Ting I. Lee, Chun Jen Chang, Gi Shih Lien, Yu Hsun Kao, Tze Fan Chao, Yi Jen Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM), and patients with DM frequently develop diabetic cardiomyopathy. Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascular system and is associated with DM. The purpose of this review was to evaluate published research on vitamin D in diabetic cardiomyopathy by searching PubMed databases. Herein, we reviewed vitamin D metabolism; evaluated the molecular, cellular, and neuroendocrine effects in native and bioactive vitamin D; and evaluated the role of vitamin D in treating cardiovascular disease and DM. Some evidence suggests that vitamin D may improve cardiovascular outcomes in diabetes through anti-inflammatory, antioxidative, antihypertrophic, antifibrotic, and antiatherosclerotic activities and by regulating advanced glycation end-product signaling, the renin-angiotensin system, and cardiac metabolism. This clinical and laboratory evidence suggests that vitamin D may be a potential agent in treating diabetic cardiomyopathy. However, using vitamin D entails possible adverse risks of hypercalcemia, hyperphosphatemia, and vascular calcifications. Therefore, future studies should be conducted that clarify the potential benefits of vitamin D through large-scale randomized clinical trials in well-defined groups of diabetic patients.

Original languageEnglish
Pages (from-to)269-279
Number of pages11
JournalNutrition Research
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Diabetic Cardiomyopathies
Vitamin D
Diabetes Mellitus
Cardiovascular Diseases
Hyperphosphatemia
Vascular Calcification
Advanced Glycosylation End Products
Hypercalcemia
Renin-Angiotensin System
Cardiovascular System
PubMed
Anti-Inflammatory Agents
Randomized Controlled Trials
Databases
Morbidity

Keywords

  • Calcitriol
  • Cardiomyopathy
  • Diabetes mellitus
  • Heart failure
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Potential of vitamin D in treating diabetic cardiomyopathy. / Lee, Ting Wei; Lee, Ting I.; Chang, Chun Jen; Lien, Gi Shih; Kao, Yu Hsun; Chao, Tze Fan; Chen, Yi Jen.

In: Nutrition Research, Vol. 35, No. 4, 01.04.2015, p. 269-279.

Research output: Contribution to journalArticle

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