Potential mechanism of blood vessel protection by resveratrol, a component of red wine

Huei Mei Huang, Yu Chih Liang, Tzu-Hurng Cheng, Cheng Heien Chen, Shu Hui Juan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Resveratrol-mediated heme oxgenase-1 (HO-1) induction has been shown to occur in primary neuronal cultures and has been implicated as having potential neuroprotective action. Further, antioxidant properties of resveratrol have been reported to protect against coronary heart disease. We attempted to examine the HO-1 inducing potency of resveratrol and the regulatory mechanism of its induction in rat aortic smooth muscle cells (RASMC). We showed that resveratrol-induced HO-1 expression was concentration- and time-dependent. The level of HO-1 expression and its promoter activity mediated by resveratrol was attenuated by nuclear factor-kappa B (NF-κB) inhibitors, but not by mitogen-activated protein kinase (MAPK) inhibitors. Deletion of NF-κB binding sites in the promoter region strongly reduced luciferase activity. Collectively, we suggest that resveratrol-mediated HO-1 expression occurs, at least in part, through the NF-κB pathway.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1042
DOIs
Publication statusPublished - 2005

Keywords

  • Heme oxygenase-1
  • Nuclear factor-kappa B
  • Rat aortic smooth muscle cell
  • Resveratrol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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