Potential long-term effects of MDMA on the basal ganglia-thalamocortical circuit

A proton MR spectroscopy and diffusion-tensor imaging study

Hua Shan Liu, Ming Chung Chou, Hsiao Wen Chung, Nai Yu Cho, Shih Wei Chiang, Chao Ying Wang, Hung Wen Kao, Guo Shu Huang, Chen Yu Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To investigate the effects of 3,4-methylenedioxymethamphetamine (MDMA, commonly known as "ecstasy") on the alterations of brain metabolites and anatomic tissue integrity related to the function of the basal ganglia-thalamocortical circuit by using proton magnetic resonance (MR) spectroscopy and diffusion-tensor MR imaging. Materials and Methods: This study was approved by a local institutional review board, and written informed consent was obtained from all subjects. Thirty-one long-term (> 1 year) MDMA users and 33 healthy subjects were enrolled. Proton MR spectroscopy from the middle frontal cortex and bilateral basal ganglia and whole-brain diffusion-tensor MR imaging were performed with a 3.0-T system. Absolute concentrations of metabolites were computed, and diffusion-tensor data were registered to the International Consortium for Brain Mapping template to facilitate voxel-based group comparison. Results: The mean myo-inositol level in the basal ganglia of MDMA users (left: 4.55 mmol/L ± 2.01 [standard deviation], right: 4.48 mmol/L ± 1.33) was significantly higher than that in control subjects (left: 3.25 mmol/L ± 1.30, right: 3.31 mmol/L ± 1.19)(P <.001). Cumulative lifetime MDMA dose showed a positive correlation with the levels of choline-containing compounds (Cho) in the right basal ganglia(r = 0.47, P =.02). MDMA users also showed a significant increase in fractional anisotropy (FA) in the bilateral thalami and significant changes in water diffusion in several regions related to the basal ganglia-thalamocortical circuit as compared with control subjects(P <.05; cluster size, >50 voxels). Conclusion: Increased myo-inositol and Cho concentrations in the basal ganglia of MDMA users are suggestive of glial response to degenerating serotonergic functions. The abnormal metabolic changes in the basal ganglia may consequently affect the inhibitory effect of the basal ganglia to the thalamus, as suggested by the increased FA in the thalamus and abnormal changes in water diffusion in the corresponding basal ganglia-thalamocortical circuit.

Original languageEnglish
Pages (from-to)531-540
Number of pages10
JournalRadiology
Volume260
Issue number2
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

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N-Methyl-3,4-methylenedioxyamphetamine
Diffusion Tensor Imaging
Basal Ganglia
Diffusion Magnetic Resonance Imaging
Inositol
Thalamus
Brain Mapping
Research Ethics Committees
Brain
Frontal Lobe
Proton Magnetic Resonance Spectroscopy
Informed Consent
Neuroglia
Healthy Volunteers
Water

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Potential long-term effects of MDMA on the basal ganglia-thalamocortical circuit : A proton MR spectroscopy and diffusion-tensor imaging study. / Liu, Hua Shan; Chou, Ming Chung; Chung, Hsiao Wen; Cho, Nai Yu; Chiang, Shih Wei; Wang, Chao Ying; Kao, Hung Wen; Huang, Guo Shu; Chen, Chen Yu.

In: Radiology, Vol. 260, No. 2, 08.2011, p. 531-540.

Research output: Contribution to journalArticle

Liu, Hua Shan ; Chou, Ming Chung ; Chung, Hsiao Wen ; Cho, Nai Yu ; Chiang, Shih Wei ; Wang, Chao Ying ; Kao, Hung Wen ; Huang, Guo Shu ; Chen, Chen Yu. / Potential long-term effects of MDMA on the basal ganglia-thalamocortical circuit : A proton MR spectroscopy and diffusion-tensor imaging study. In: Radiology. 2011 ; Vol. 260, No. 2. pp. 531-540.
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