Potential activated pathways related to progress of bladder cancer explored by protein networks with gene expression changes

F. H. Hung, H. W. Chiu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Cell signaling pathway is an important facet of biological life. The integration of protein interaction and gene expression data is suitable to uncover the regulation of pathway. However, these methods are still confined to a partial region of large-scale genomics and whole-proteomics. In previous studies for this topic, researches usually focused on the gene level or some limited groups, thus several cancer-related genes cannot appear to known pathway maps. This study presents an approach to finding potential fragments of activated pathways around known pathways between the different stages of cancers. We used a maximum score-based function that integrates genomics and proteomics information. The quantification of the strength of gene expression change was implemented and the global status pathway maps were illustrated. The resulting map shows a possible correspondence between known pathway and cancer-related genes that are not on the known pathway. Comparing diverse status pathway map reveals a global change of diverse disease states pathway level. In this study, the data of bladder cancer was analyzed to explain which potential fragments of pathway play important role at different cancer stages. The insight we gain from the pathway map of different disease statuses helps us to understand the progress of cancer.

Original languageEnglish
Title of host publicationIFMBE Proceedings
PublisherSpringer Verlag
Pages605-608
Number of pages4
Volume45
ISBN (Print)9783319111278
DOIs
Publication statusPublished - 2015
Event6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014 - Dubrovnik, Croatia
Duration: Sep 7 2014Sep 11 2014

Other

Other6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014
CountryCroatia
CityDubrovnik
Period9/7/149/11/14

Fingerprint

Gene expression
Proteins
Genes
Cell signaling
Genomics
Proteomics

Keywords

  • Bioinformatics
  • Biopathway
  • Cancer
  • Gene expression

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Potential activated pathways related to progress of bladder cancer explored by protein networks with gene expression changes. / Hung, F. H.; Chiu, H. W.

IFMBE Proceedings. Vol. 45 Springer Verlag, 2015. p. 605-608.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hung, FH & Chiu, HW 2015, Potential activated pathways related to progress of bladder cancer explored by protein networks with gene expression changes. in IFMBE Proceedings. vol. 45, Springer Verlag, pp. 605-608, 6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014, Dubrovnik, Croatia, 9/7/14. https://doi.org/10.1007/978-3-319-11128-5_151
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