Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck

Tseng Cheng Chen, Chi Te Wang, Jenq Yuh Ko, Pei Jen Lou, Tsung Lin Yang, Lai Lei Ting, Chun Wei Wang, Ya Ling Hu, Cheng Ping Wang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background. The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear. Methods. The medical records of all patients with pathologic T1-2/N0-1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed. Results. There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5-year disease-free survival rates were 81.2% and 53% for the patients with and without PORT, respectively (p = .03). The overall 5-year survival rates were 77% and 70.5% for the patients with and without PORT, respectively (p = .36). Multivariate analyses showed that PORT had the only protective effect (p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence (p = .03). Conclusions. Approximately one-third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease-free survival.

Original languageEnglish
Pages (from-to)555-561
Number of pages7
JournalHead and Neck
Volume32
Issue number5
DOIs
Publication statusPublished - May 1 2010

Fingerprint

Tongue Neoplasms
Mouth Neoplasms
Neck
Radiotherapy
Tongue
Disease-Free Survival
Squamous Cell Carcinoma
Survival Rate
Recurrence
Neck Dissection
Medical Records
Multivariate Analysis

Keywords

  • Adjuvant radiotherapy
  • Extracapsular spread
  • Recurrence
  • Squamous cell carcinoma
  • Survival
  • Tongue cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Chen, T. C., Wang, C. T., Ko, J. Y., Lou, P. J., Yang, T. L., Ting, L. L., ... Wang, C. P. (2010). Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck. Head and Neck, 32(5), 555-561. https://doi.org/10.1002/hed.21217

Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck. / Chen, Tseng Cheng; Wang, Chi Te; Ko, Jenq Yuh; Lou, Pei Jen; Yang, Tsung Lin; Ting, Lai Lei; Wang, Chun Wei; Hu, Ya Ling; Wang, Cheng Ping.

In: Head and Neck, Vol. 32, No. 5, 01.05.2010, p. 555-561.

Research output: Contribution to journalArticle

Chen, TC, Wang, CT, Ko, JY, Lou, PJ, Yang, TL, Ting, LL, Wang, CW, Hu, YL & Wang, CP 2010, 'Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck', Head and Neck, vol. 32, no. 5, pp. 555-561. https://doi.org/10.1002/hed.21217
Chen, Tseng Cheng ; Wang, Chi Te ; Ko, Jenq Yuh ; Lou, Pei Jen ; Yang, Tsung Lin ; Ting, Lai Lei ; Wang, Chun Wei ; Hu, Ya Ling ; Wang, Cheng Ping. / Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck. In: Head and Neck. 2010 ; Vol. 32, No. 5. pp. 555-561.
@article{32a60bd71ea5494696ab46848e0aff2d,
title = "Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck",
abstract = "Background. The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear. Methods. The medical records of all patients with pathologic T1-2/N0-1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed. Results. There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5-year disease-free survival rates were 81.2{\%} and 53{\%} for the patients with and without PORT, respectively (p = .03). The overall 5-year survival rates were 77{\%} and 70.5{\%} for the patients with and without PORT, respectively (p = .36). Multivariate analyses showed that PORT had the only protective effect (p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence (p = .03). Conclusions. Approximately one-third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease-free survival.",
keywords = "Adjuvant radiotherapy, Extracapsular spread, Recurrence, Squamous cell carcinoma, Survival, Tongue cancer",
author = "Chen, {Tseng Cheng} and Wang, {Chi Te} and Ko, {Jenq Yuh} and Lou, {Pei Jen} and Yang, {Tsung Lin} and Ting, {Lai Lei} and Wang, {Chun Wei} and Hu, {Ya Ling} and Wang, {Cheng Ping}",
year = "2010",
month = "5",
day = "1",
doi = "10.1002/hed.21217",
language = "English",
volume = "32",
pages = "555--561",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck

AU - Chen, Tseng Cheng

AU - Wang, Chi Te

AU - Ko, Jenq Yuh

AU - Lou, Pei Jen

AU - Yang, Tsung Lin

AU - Ting, Lai Lei

AU - Wang, Chun Wei

AU - Hu, Ya Ling

AU - Wang, Cheng Ping

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Background. The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear. Methods. The medical records of all patients with pathologic T1-2/N0-1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed. Results. There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5-year disease-free survival rates were 81.2% and 53% for the patients with and without PORT, respectively (p = .03). The overall 5-year survival rates were 77% and 70.5% for the patients with and without PORT, respectively (p = .36). Multivariate analyses showed that PORT had the only protective effect (p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence (p = .03). Conclusions. Approximately one-third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease-free survival.

AB - Background. The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear. Methods. The medical records of all patients with pathologic T1-2/N0-1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed. Results. There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5-year disease-free survival rates were 81.2% and 53% for the patients with and without PORT, respectively (p = .03). The overall 5-year survival rates were 77% and 70.5% for the patients with and without PORT, respectively (p = .36). Multivariate analyses showed that PORT had the only protective effect (p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence (p = .03). Conclusions. Approximately one-third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease-free survival.

KW - Adjuvant radiotherapy

KW - Extracapsular spread

KW - Recurrence

KW - Squamous cell carcinoma

KW - Survival

KW - Tongue cancer

UR - http://www.scopus.com/inward/record.url?scp=77951528634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951528634&partnerID=8YFLogxK

U2 - 10.1002/hed.21217

DO - 10.1002/hed.21217

M3 - Article

C2 - 19691114

AN - SCOPUS:77951528634

VL - 32

SP - 555

EP - 561

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 5

ER -