Postoperative radiotherapy for primary early oral tongue cancer with pathologic N1 neck

Tseng Cheng Chen, Chi Te Wang, Jenq Yuh Ko, Pei Jen Lou, Tsung Lin Yang, Lai Lei Ting, Chun Wei Wang, Ya Ling Hu, Cheng Ping Wang

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Background. The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear. Methods. The medical records of all patients with pathologic T1-2/N0-1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed. Results. There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5-year disease-free survival rates were 81.2% and 53% for the patients with and without PORT, respectively (p = .03). The overall 5-year survival rates were 77% and 70.5% for the patients with and without PORT, respectively (p = .36). Multivariate analyses showed that PORT had the only protective effect (p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence (p = .03). Conclusions. Approximately one-third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease-free survival.

Original languageEnglish
Pages (from-to)555-561
Number of pages7
JournalHead and Neck
Volume32
Issue number5
DOIs
Publication statusPublished - May 1 2010

Keywords

  • Adjuvant radiotherapy
  • Extracapsular spread
  • Recurrence
  • Squamous cell carcinoma
  • Survival
  • Tongue cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

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