Postirradiated neuroendocrine carcinoma of the sinonasal tract

Cheng Ping Wang, Chia Ying Hsieh, Yih Leong Chang, Pei Jen Lou, Tsung Lin Yang, Lai Lei Ting, Jenq Yuh Ko

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVES/HYPOTHESIS: Neuroendocrine carcinoma (NEC) of the sinonasal tract is rare. In this present study, we report our treatment experience with sinonasal NEC. STUDY DESIGN: Retrospective case series. METHODS: A retrospective review of the clinical outcomes and pathology of 18 patients with NEC arising from the sinonasal region. RESULTS: Ten tumors were primary NEC without previous radiation, and eight tumors were postirradiated NEC occurring within the radiation field for previous nasopharyngeal carcinoma in six patients and tonsillar lymphoma in one and neck metastasis of unknown primary origin in one, with an interval between previous radiotherapy and diagnosis of NEC from 82 to 385 months, with a mean of 197 months. Fifteen tumors were small cell carcinoma, two were atypical carcinoid, and one was typical carcinoid tumor. Fifteen patients underwent surgery with/without postoperative adjuvant chemoradiotherapy. Three patients received induction chemotherapy or primary radiotherapy with further definitive treatment. The 5-year disease-free and overall survival rates of all 18 patients were 56.1% and 62.2%, respectively. In comparing primary NEC with postirradiated NEC, they were similar in age, sex distribution, stage, pathology, and treatment, and the 5-year overall survival rates were 70% and 62.5%, respectively. CONCLUSIONS: In this series, postirradiated NEC is common, which may be the result of there being a large number of long-term nasopharyngeal carcinoma survivors. The prognoses of postirradiated NEC and primary NEC appear to be similar despite the relatively short follow-up period in the postirradiated NEC group.

Original languageEnglish
Pages (from-to)804-809
Number of pages6
JournalLaryngoscope
Volume118
Issue number5
DOIs
Publication statusPublished - May 1 2008
Externally publishedYes

Fingerprint

Neuroendocrine Carcinoma
Carcinoid Tumor
Radiotherapy
Survival Rate
Adjuvant Chemoradiotherapy
Radiation
Neoplasms
Sex Distribution
Induction Chemotherapy
Clinical Pathology
Small Cell Carcinoma
Age Distribution
Disease-Free Survival
Survivors
Lymphoma
Neck
Therapeutics

Keywords

  • Carcinoid
  • Neuroendocrine carcinoma
  • Radiation-induced malignancy
  • Radiotherapy
  • Sinonasal tract

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Wang, C. P., Hsieh, C. Y., Chang, Y. L., Lou, P. J., Yang, T. L., Ting, L. L., & Ko, J. Y. (2008). Postirradiated neuroendocrine carcinoma of the sinonasal tract. Laryngoscope, 118(5), 804-809. https://doi.org/10.1097/MLG.0b013e3181671491

Postirradiated neuroendocrine carcinoma of the sinonasal tract. / Wang, Cheng Ping; Hsieh, Chia Ying; Chang, Yih Leong; Lou, Pei Jen; Yang, Tsung Lin; Ting, Lai Lei; Ko, Jenq Yuh.

In: Laryngoscope, Vol. 118, No. 5, 01.05.2008, p. 804-809.

Research output: Contribution to journalArticle

Wang, CP, Hsieh, CY, Chang, YL, Lou, PJ, Yang, TL, Ting, LL & Ko, JY 2008, 'Postirradiated neuroendocrine carcinoma of the sinonasal tract', Laryngoscope, vol. 118, no. 5, pp. 804-809. https://doi.org/10.1097/MLG.0b013e3181671491
Wang, Cheng Ping ; Hsieh, Chia Ying ; Chang, Yih Leong ; Lou, Pei Jen ; Yang, Tsung Lin ; Ting, Lai Lei ; Ko, Jenq Yuh. / Postirradiated neuroendocrine carcinoma of the sinonasal tract. In: Laryngoscope. 2008 ; Vol. 118, No. 5. pp. 804-809.
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AU - Ting, Lai Lei

AU - Ko, Jenq Yuh

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N2 - OBJECTIVES/HYPOTHESIS: Neuroendocrine carcinoma (NEC) of the sinonasal tract is rare. In this present study, we report our treatment experience with sinonasal NEC. STUDY DESIGN: Retrospective case series. METHODS: A retrospective review of the clinical outcomes and pathology of 18 patients with NEC arising from the sinonasal region. RESULTS: Ten tumors were primary NEC without previous radiation, and eight tumors were postirradiated NEC occurring within the radiation field for previous nasopharyngeal carcinoma in six patients and tonsillar lymphoma in one and neck metastasis of unknown primary origin in one, with an interval between previous radiotherapy and diagnosis of NEC from 82 to 385 months, with a mean of 197 months. Fifteen tumors were small cell carcinoma, two were atypical carcinoid, and one was typical carcinoid tumor. Fifteen patients underwent surgery with/without postoperative adjuvant chemoradiotherapy. Three patients received induction chemotherapy or primary radiotherapy with further definitive treatment. The 5-year disease-free and overall survival rates of all 18 patients were 56.1% and 62.2%, respectively. In comparing primary NEC with postirradiated NEC, they were similar in age, sex distribution, stage, pathology, and treatment, and the 5-year overall survival rates were 70% and 62.5%, respectively. CONCLUSIONS: In this series, postirradiated NEC is common, which may be the result of there being a large number of long-term nasopharyngeal carcinoma survivors. The prognoses of postirradiated NEC and primary NEC appear to be similar despite the relatively short follow-up period in the postirradiated NEC group.

AB - OBJECTIVES/HYPOTHESIS: Neuroendocrine carcinoma (NEC) of the sinonasal tract is rare. In this present study, we report our treatment experience with sinonasal NEC. STUDY DESIGN: Retrospective case series. METHODS: A retrospective review of the clinical outcomes and pathology of 18 patients with NEC arising from the sinonasal region. RESULTS: Ten tumors were primary NEC without previous radiation, and eight tumors were postirradiated NEC occurring within the radiation field for previous nasopharyngeal carcinoma in six patients and tonsillar lymphoma in one and neck metastasis of unknown primary origin in one, with an interval between previous radiotherapy and diagnosis of NEC from 82 to 385 months, with a mean of 197 months. Fifteen tumors were small cell carcinoma, two were atypical carcinoid, and one was typical carcinoid tumor. Fifteen patients underwent surgery with/without postoperative adjuvant chemoradiotherapy. Three patients received induction chemotherapy or primary radiotherapy with further definitive treatment. The 5-year disease-free and overall survival rates of all 18 patients were 56.1% and 62.2%, respectively. In comparing primary NEC with postirradiated NEC, they were similar in age, sex distribution, stage, pathology, and treatment, and the 5-year overall survival rates were 70% and 62.5%, respectively. CONCLUSIONS: In this series, postirradiated NEC is common, which may be the result of there being a large number of long-term nasopharyngeal carcinoma survivors. The prognoses of postirradiated NEC and primary NEC appear to be similar despite the relatively short follow-up period in the postirradiated NEC group.

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