Posterior atrophy and medial temporal atrophy scores are associated with different symptoms in patients with Alzheimer's disease and mild cognitive impairment

Jung Lung Hsu, Wei Ju Lee, Yi Chu Liao, Rong-Long Shiu, Shuu Jiun Wang, Jong Ling Fuh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Whether the occurrence of posterior atrophy (PA) and medial temporal lobe atrophy (MTA) was correlated with cognitive and non-cognitive symptoms in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients are unclear. Methods Patients with probable AD and MCI from a medical center outpatient clinic received attention, memory, language, executive function evaluation and Mini-Mental Status Examination (MMSE). The severity of dementia was rated by the Clinical Dementia Rating (CDR) Sum of Box (CDR-SB). The neuropsychiatric inventory (NPI) subscale of agitation/aggression and mood symptoms was also applied. Magnetic resonance imaging (MRI) was scored visually for the MTA, PA and white matter hyperintensity (WMH) scores. Results We recruited 129 AD and 31MCI (mean age 78.8 years, 48%female) patients. MMSE scores, memory, language and executive function were all significantly decreased in individuals with AD than those with MCI (p <0.01). MTA and PA scores reflected significant atrophy in AD compared to MCI; however, theWMHscores did not differ. The MTA scores were significantly correlated with the frontal, parieto-occipital and globalWMHscores (p <0.01) whilethe PA scores showed a correlation with the parieto-occipital and temporalWMHscores (p <0.01). After adjusting for age, education, APOE4 gene and diagnostic group covariates, the MTA scores showed a significant association with MMSE and CDR-SB, while the right side PA scores were significantly associated with NPI-Agitation/aggression subscales (p <0.01). Conclusion Regional atrophy is related to different symptoms in patients with AD or MCI. PA score is useful as a complementary measure for non-cognitive symptom.

Original languageEnglish
Article numberA1159
JournalPLoS One
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 15 2015

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Alzheimer disease
atrophy
signs and symptoms (animals and humans)
Atrophy
Alzheimer Disease
Temporal Lobe
dementia
Data storage equipment
Dementia
Function evaluation
Executive Function
agitation
Magnetic resonance imaging
Aggression
Cognitive Dysfunction
aggression
Genes
Education
Language
Equipment and Supplies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Posterior atrophy and medial temporal atrophy scores are associated with different symptoms in patients with Alzheimer's disease and mild cognitive impairment. / Hsu, Jung Lung; Lee, Wei Ju; Liao, Yi Chu; Shiu, Rong-Long; Wang, Shuu Jiun; Fuh, Jong Ling.

In: PLoS One, Vol. 10, No. 9, A1159, 15.09.2015.

Research output: Contribution to journalArticle

Hsu, Jung Lung ; Lee, Wei Ju ; Liao, Yi Chu ; Shiu, Rong-Long ; Wang, Shuu Jiun ; Fuh, Jong Ling. / Posterior atrophy and medial temporal atrophy scores are associated with different symptoms in patients with Alzheimer's disease and mild cognitive impairment. In: PLoS One. 2015 ; Vol. 10, No. 9.
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abstract = "Background Whether the occurrence of posterior atrophy (PA) and medial temporal lobe atrophy (MTA) was correlated with cognitive and non-cognitive symptoms in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients are unclear. Methods Patients with probable AD and MCI from a medical center outpatient clinic received attention, memory, language, executive function evaluation and Mini-Mental Status Examination (MMSE). The severity of dementia was rated by the Clinical Dementia Rating (CDR) Sum of Box (CDR-SB). The neuropsychiatric inventory (NPI) subscale of agitation/aggression and mood symptoms was also applied. Magnetic resonance imaging (MRI) was scored visually for the MTA, PA and white matter hyperintensity (WMH) scores. Results We recruited 129 AD and 31MCI (mean age 78.8 years, 48{\%}female) patients. MMSE scores, memory, language and executive function were all significantly decreased in individuals with AD than those with MCI (p <0.01). MTA and PA scores reflected significant atrophy in AD compared to MCI; however, theWMHscores did not differ. The MTA scores were significantly correlated with the frontal, parieto-occipital and globalWMHscores (p <0.01) whilethe PA scores showed a correlation with the parieto-occipital and temporalWMHscores (p <0.01). After adjusting for age, education, APOE4 gene and diagnostic group covariates, the MTA scores showed a significant association with MMSE and CDR-SB, while the right side PA scores were significantly associated with NPI-Agitation/aggression subscales (p <0.01). Conclusion Regional atrophy is related to different symptoms in patients with AD or MCI. PA score is useful as a complementary measure for non-cognitive symptom.",
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T1 - Posterior atrophy and medial temporal atrophy scores are associated with different symptoms in patients with Alzheimer's disease and mild cognitive impairment

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AU - Lee, Wei Ju

AU - Liao, Yi Chu

AU - Shiu, Rong-Long

AU - Wang, Shuu Jiun

AU - Fuh, Jong Ling

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N2 - Background Whether the occurrence of posterior atrophy (PA) and medial temporal lobe atrophy (MTA) was correlated with cognitive and non-cognitive symptoms in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients are unclear. Methods Patients with probable AD and MCI from a medical center outpatient clinic received attention, memory, language, executive function evaluation and Mini-Mental Status Examination (MMSE). The severity of dementia was rated by the Clinical Dementia Rating (CDR) Sum of Box (CDR-SB). The neuropsychiatric inventory (NPI) subscale of agitation/aggression and mood symptoms was also applied. Magnetic resonance imaging (MRI) was scored visually for the MTA, PA and white matter hyperintensity (WMH) scores. Results We recruited 129 AD and 31MCI (mean age 78.8 years, 48%female) patients. MMSE scores, memory, language and executive function were all significantly decreased in individuals with AD than those with MCI (p <0.01). MTA and PA scores reflected significant atrophy in AD compared to MCI; however, theWMHscores did not differ. The MTA scores were significantly correlated with the frontal, parieto-occipital and globalWMHscores (p <0.01) whilethe PA scores showed a correlation with the parieto-occipital and temporalWMHscores (p <0.01). After adjusting for age, education, APOE4 gene and diagnostic group covariates, the MTA scores showed a significant association with MMSE and CDR-SB, while the right side PA scores were significantly associated with NPI-Agitation/aggression subscales (p <0.01). Conclusion Regional atrophy is related to different symptoms in patients with AD or MCI. PA score is useful as a complementary measure for non-cognitive symptom.

AB - Background Whether the occurrence of posterior atrophy (PA) and medial temporal lobe atrophy (MTA) was correlated with cognitive and non-cognitive symptoms in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients are unclear. Methods Patients with probable AD and MCI from a medical center outpatient clinic received attention, memory, language, executive function evaluation and Mini-Mental Status Examination (MMSE). The severity of dementia was rated by the Clinical Dementia Rating (CDR) Sum of Box (CDR-SB). The neuropsychiatric inventory (NPI) subscale of agitation/aggression and mood symptoms was also applied. Magnetic resonance imaging (MRI) was scored visually for the MTA, PA and white matter hyperintensity (WMH) scores. Results We recruited 129 AD and 31MCI (mean age 78.8 years, 48%female) patients. MMSE scores, memory, language and executive function were all significantly decreased in individuals with AD than those with MCI (p <0.01). MTA and PA scores reflected significant atrophy in AD compared to MCI; however, theWMHscores did not differ. The MTA scores were significantly correlated with the frontal, parieto-occipital and globalWMHscores (p <0.01) whilethe PA scores showed a correlation with the parieto-occipital and temporalWMHscores (p <0.01). After adjusting for age, education, APOE4 gene and diagnostic group covariates, the MTA scores showed a significant association with MMSE and CDR-SB, while the right side PA scores were significantly associated with NPI-Agitation/aggression subscales (p <0.01). Conclusion Regional atrophy is related to different symptoms in patients with AD or MCI. PA score is useful as a complementary measure for non-cognitive symptom.

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