Abstract

Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5% risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2010

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Craniocerebral Trauma
Traumatic Intracranial Hemorrhage
Skull Fractures
Intracranial Hemorrhages
Cerebrospinal Fluid Leak
Traumatic Brain Injury
Brain Injuries
Medical Records
Odds Ratio

Keywords

  • cerebrospinal fluid leakage
  • intracranial hemorrhage
  • post-traumatic amnesia
  • skull fracture
  • traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Post-traumatic Cerebrospinal Fluid Leakage: A Risk Indicator to Predict Outcome Following Traumatic Brain Injury?",
abstract = "Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5{\%} risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.",
keywords = "cerebrospinal fluid leakage, intracranial hemorrhage, post-traumatic amnesia, skull fracture, traumatic brain injury",
author = "Chiu, {Wen Ta} and Tsai, {Shin Han} and Tsai, {Wan Chen} and Lin, {Jia Wei} and Hung, {Kuo Sheng} and Lin, {Tien Jen}",
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language = "English",
volume = "2",
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T1 - Post-traumatic Cerebrospinal Fluid Leakage

T2 - A Risk Indicator to Predict Outcome Following Traumatic Brain Injury?

AU - Chiu, Wen Ta

AU - Tsai, Shin Han

AU - Tsai, Wan Chen

AU - Lin, Jia Wei

AU - Hung, Kuo Sheng

AU - Lin, Tien Jen

PY - 2010/2

Y1 - 2010/2

N2 - Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5% risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.

AB - Background/Purpose: The aim of the present study was to review the clinical manifestations, risk factors and outcome in traumatic brain injury (TBI) patients with post-traumatic cerebrospinal fluid (CSF) leakage. Methods: We reviewed the medical records of 1,323 patients who were identified with CSF leakage that occurred after head trauma. Results: Patients complicated with CSF leakage manifested a more rigorous clinical course and poorer outcome compared to patients with other TBI features: in mild head injury, patients with brain injury complicated with CSF leakage alone had a 24.5% risk ratio for developing intracranial hemorrhage, and the presence of post-traumatic CSF leakage with or without skull fracture resulted in a higher percentage of fatality. Conclusion: Post-traumatic CSF leakage amongst head injury patients has serious complications in nonfatal TBI cases, and indicates a risk of developing post-traumatic intracranial hemorrhage as the patients' final outcome.

KW - cerebrospinal fluid leakage

KW - intracranial hemorrhage

KW - post-traumatic amnesia

KW - skull fracture

KW - traumatic brain injury

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