Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction

Jiunn Tay Lee, Chung Hsing Chou, Nai Yu Cho, Yueh Feng Sung, Fu Chi Yang, Cheng Yu Chen, Yu Hua Lai, Chun I. Chiang, Chi Ming Chu, Jiann Chyun Lin, Yaw Don Hsu, Jau Shyong Hong, Giia Sheun Peng, De Maw Chuang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Animal stroke models suggest that valproate has multiple neuroprotective mechanisms against ischemic brain damage. This study investigated whether valproate improves functional recovery in patients with acute middle cerebral artery (MCA) infarction. This was an open-label controlled trial. Three to 24 hours after acute MCA infarction, patients were assigned to either the valproate group (n = 17) or the non-valproate group (n = 17). The valproate group received intravenous valproate (400 mg) at enrollment, and then every 12 hours for three days, followed by oral valproate (500 mg) every 12 hours for three months. Neurological function, laboratory data, and brain magnetic resonance imaging were examined at stroke onset, and at two-week and three-month follow-up. No signifcant differences were observed between the groups with regard to demographics or baseline characteristics. All patients were elderly, had a high pretreatment score on the NIH stroke scale (NIHSS), and slow stroke lesion growth with a fnal large infarct volume at two-week follow-up. At the three-month follow-up, functional outcome between pre- and post-treatment had improved signifcantly in the valproate group (NIHSS, p = 0.004; modifed Rankin scale (mRS), p = 0.007; Barthel index (BI), p = 0.001). No such improvement was noted in the NIHSS or mRS for the non-valproate group, though mild improvement was seen on the BI (p = 0.022). This open-label trial is the frst to demonstrate that valproate treatment markedly improves functional outcome in patients with acute MCA infarction.

Original languageEnglish
Pages (from-to)820-830
Number of pages11
JournalAmerican Journal of Translational Research
Volume6
Issue number6
Publication statusPublished - 2014

Keywords

  • Ischemic stroke
  • Neuroprotection
  • Stroke outcome
  • Valproate

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Clinical Biochemistry
  • Molecular Medicine

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