Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract

Ming Fang Wu, Hsu Feng Lu, Yu Ming Hsu, Ming Chu Tang, Hsueh Chin Chen, Ching Sung Lee, Yi Yuan Yang, Ming Yang Yeh, Hsiung Kwang Chung, Yi Ping Huang, Chih Chung Wu, Jing Gung Chung

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6 Citations (Scopus)

Abstract

Agaricus blazei Murill extract (ABM) has been reported to possess antitumor effects. In this study, the role of ABM in tumor growth and metastasis in vivo was evaluated in experimental Smmu 7721 hepatoma cells in severe combined immunodeficiency (SCID) mice and B16F10 melanoma cells lung metastasis in C57BL/6 mice. For the tumor growth model, the size of the liver tumor mass was about 10 mm to 20 mm in the control group. In comparison with the control group, the tumor mass seem to grow slowly with ABM treatment, especially at the high dose. For the tumor metastasis model, after a six-week treatment, the survival rates of B6 mice were 0%, 30%, 10% and 50% for control group, low, median and high concentration ABM treatment groups, respectively. The survival rate showed that pretreatment of C57BL/6 (B6) mice with ABM lengthened their lifespan after tumor cell inoculation, which supports the notion that ABM successfully reduced lung metastasis formation by B16F10 melanoma cells. The treatment effect was dependent on the concentration of ABM for tumor growth and metastasis in these models.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalIn Vivo
Volume25
Issue number3
Publication statusPublished - May 2011

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Keywords

  • Agaricus blazei Murill
  • Antitumor effects
  • B16F10 melanoma cells
  • Smmu 7721 hepatoma cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Wu, M. F., Lu, H. F., Hsu, Y. M., Tang, M. C., Chen, H. C., Lee, C. S., Yang, Y. Y., Yeh, M. Y., Chung, H. K., Huang, Y. P., Wu, C. C., & Chung, J. G. (2011). Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract. In Vivo, 25(3), 399-404.