Possible contributions of thyroid hormone replacement to specific behaviors of cancer

Aleck Hercbergs, Paul J. Davis, Hung Yun Lin, Shaker A. Mousa

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

L-Thyroxine (T4) is the principal replacement hormone for patients who have hypothyroidism. Some preclinical and clinical evidence supports the possibility that T4 can at least permissively affect certain features of established cancers and cancer-relevant angiogenesis. Thus, in the occasional patient with hypothyroidism and concomitant cancer, it appears reasonable to consider thyroid hormone replacement exclusively with 3,3′,5-triiodo-L-thyronine (T3). This use of T3 has been shown to be effective and safe in early experience with medical induction of euthyroid hypothyroxinemia in patients with advanced solid tumors.

Original languageEnglish
Pages (from-to)655-659
Number of pages5
JournalBiomedicine and Pharmacotherapy
Volume84
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Thyroid Hormones
Hypothyroidism
Neoplasms
Thyronines
Thyroxine
Hormones

Keywords

  • 3,3′,5-Triiodo-L-thyronine (T)
  • Angiogenesis
  • Apoptosis
  • Hypothyroidism
  • L-Thyroxine (T)
  • Thyroid cancer
  • Tyrosine kinase inhibitor (TKI)

ASJC Scopus subject areas

  • Pharmacology

Cite this

Possible contributions of thyroid hormone replacement to specific behaviors of cancer. / Hercbergs, Aleck; Davis, Paul J.; Lin, Hung Yun; Mousa, Shaker A.

In: Biomedicine and Pharmacotherapy, Vol. 84, 01.12.2016, p. 655-659.

Research output: Contribution to journalReview article

Hercbergs, Aleck ; Davis, Paul J. ; Lin, Hung Yun ; Mousa, Shaker A. / Possible contributions of thyroid hormone replacement to specific behaviors of cancer. In: Biomedicine and Pharmacotherapy. 2016 ; Vol. 84. pp. 655-659.
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