Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients

Yao Chang Liu, Jen Pi Tsai, Li Hsuan Wang, Ming Che Lee, Bang Gee Hsu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Fibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients. Methods: The fasting blood samples of RT recipients (n = 66) were collected and analyzed. Results: A total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a higher prevalence of diabetes (P < 0.001), hypertension (P = 0.001), and metabolic syndrome (P = 0.023); longer post-RT duration (P = 0.006); higher systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.024); and higher fasting glucose (P = 0.002), total cholesterol (P = 0.049), blood urea nitrogen (P = 0.027), phosphorus (P = 0.047), and FGF-23 concentrations (P = 0.003) and FGF-23/α-klotho ratio (P < 0.001) but lower klotho concentrations (P = 0.025) than those in the control group. Moreover, FGF-23 concentration (adjusted odds ratio: 1.057, 95% confidence interval: 1.011–1.105, P = 0.015) was found to be an independent predictor of peripheral AS in RT recipients. Conclusions: Serum FGF-23 concentration was a significant predictor of peripheral AS in RT recipients.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalClinica Chimica Acta
Volume505
DOIs
Publication statusPublished - Jun 2020
Externally publishedYes

Keywords

  • Arterial stiffness
  • Fibroblast growth factor 23
  • Renal transplantation
  • α-Klotho

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint

Dive into the research topics of 'Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients'. Together they form a unique fingerprint.

Cite this