Positive correlation of serum adipocyte fatty acid binding protein levels with metabolic syndrome in kidney transplantation patients

I. Ching Huang, Chao Chien Chang, Chung Jen Lee, Yen Cheng Chen, Ming Che Lee, Bang Gee Hsu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Adipocyte fatty acid binding protein (A-FABP) is significantly expressed in white and brown adipose tissue, monocytes, and macrophages and is a central regulator of systemic insulin sensitivity. Metabolic syndrome (MetS) is a risk factor for post-transplant diabetes mellitus (PTDM), chronic graft dysfunction, graft loss, and patient death in kidney transplantation (KT) patients. This study was undertaken to evaluate the relationship between MetS and fasting serum A-FABP concentration in KT patients. Fasting blood samples were obtained from 70 KT patients. Serum A-FABP levels were measured using a commercial enzyme-linked immunosorbent assay kit. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation. Twenty-two patients (31.4%) had MetS. KT patients with hypertension (P = 0.011), diabetes (P = 0.002), body weight (P = 0.004), body mass index (BMI, P = 0.001), waist circumference (P < 0.001), body fat mass (P < 0.001), systolic blood pressure (SBP, P = 0.017), total cholesterol (TCH, P = 0.028), triglycerides (TG, P = 0.001), blood urea nitrogen (BUN, P = 0.003), insulin (P < 0.001), homeostasis model assessment of insulin resistance (HOMA-IR, P < 0.001), and A-FABP level (P < 0.001) were higher, while high-density lipoprotein cholesterol (HDL-C, P = 0.010) was lower in KT patients with MetS. Moreover, SBP (β = 0.347, adjusted R2 change = 0.108, P = 0.001) and logarithmically transformed triglycerides (log-TG, β = 0.393, adjusted R2 change = 0.189, P < 0.001) were associated with A-FABP levels in a multivariable forward stepwise linear regression analysis among KT patients. The results of our study showed that the fasting A-FABP level was positively associated with MetS in KT patients. SBP and log-TG were independent predictors of the serum A-FABP level among KT patients.

Original languageEnglish
Pages (from-to)8727-8734
Number of pages8
JournalInternational Journal of Clinical and Experimental Pathology
Volume10
Issue number8
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Adipocyte fatty acid binding protein
  • Kidney transplantation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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