Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults

Chien Yu Lin, Hui Ling Lee, Yu Chuan Chen, Guang Wen Lien, Lain Yu Lin, Li Li Wen, Chien Chang Liao, Kuo Liong Chien, Fung Chang Sung, Pau Chung Chen, Ta Chen Su

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if urinary levels of the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine (AAMA) and the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) are associated. The mean (SD) AAMA and 8-OHdG were 76.54 (76.42). μg/L and 3.48 (2.37). μg/L, respectively. In linear regression analyses, a 1-unit increase in natural log AAMA was significantly associated with an increase in natural log 8-OHdG (μg/g creatinine) (β=0.044, SE=0.019, P=0.020) after controlling for covariates. Subpopulation analyses showed AAMA and 8-OHdG were significantly associated with males, adolescents, non-current smokers, without alcohol consumption, subjects, body mass index ≥24, and homeostasis model assessment of insulin resistance score ≥0.9. In conclusion, higher urinary AAMA concentrations were associated with increased levels of urinary 8-OHdG in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and oxidative stress.

Original languageEnglish
Pages (from-to)372-377
Number of pages6
JournalJournal of Hazardous Materials
Volume261
DOIs
Publication statusPublished - Oct 5 2013

Fingerprint

Oxidative stress
Acrylamide
Metabolites
Young Adult
metabolite
Association reactions
Oxidative Stress
Population Growth
Insulin
homeostasis
subpopulation
Smoke
Linear regression
smoke
body mass
alcohol
Animals
Alcohols
Tobacco Products
Alcohol Drinking

Keywords

  • 8-Hydroxydeoxyguanosine (8-OHdG)
  • Acrylamide
  • N-Acetyl-S-(propionamide)-cysteine (AAMA)
  • Oxidative stress

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Waste Management and Disposal
  • Environmental Chemistry
  • Environmental Engineering

Cite this

Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. / Lin, Chien Yu; Lee, Hui Ling; Chen, Yu Chuan; Lien, Guang Wen; Lin, Lain Yu; Wen, Li Li; Liao, Chien Chang; Chien, Kuo Liong; Sung, Fung Chang; Chen, Pau Chung; Su, Ta Chen.

In: Journal of Hazardous Materials, Vol. 261, 05.10.2013, p. 372-377.

Research output: Contribution to journalArticle

Lin, Chien Yu ; Lee, Hui Ling ; Chen, Yu Chuan ; Lien, Guang Wen ; Lin, Lain Yu ; Wen, Li Li ; Liao, Chien Chang ; Chien, Kuo Liong ; Sung, Fung Chang ; Chen, Pau Chung ; Su, Ta Chen. / Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. In: Journal of Hazardous Materials. 2013 ; Vol. 261. pp. 372-377.
@article{9acf96c9753f452e8b9851729cafedad,
title = "Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults",
abstract = "Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if urinary levels of the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine (AAMA) and the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) are associated. The mean (SD) AAMA and 8-OHdG were 76.54 (76.42). μg/L and 3.48 (2.37). μg/L, respectively. In linear regression analyses, a 1-unit increase in natural log AAMA was significantly associated with an increase in natural log 8-OHdG (μg/g creatinine) (β=0.044, SE=0.019, P=0.020) after controlling for covariates. Subpopulation analyses showed AAMA and 8-OHdG were significantly associated with males, adolescents, non-current smokers, without alcohol consumption, subjects, body mass index ≥24, and homeostasis model assessment of insulin resistance score ≥0.9. In conclusion, higher urinary AAMA concentrations were associated with increased levels of urinary 8-OHdG in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and oxidative stress.",
keywords = "8-Hydroxydeoxyguanosine (8-OHdG), Acrylamide, N-Acetyl-S-(propionamide)-cysteine (AAMA), Oxidative stress",
author = "Lin, {Chien Yu} and Lee, {Hui Ling} and Chen, {Yu Chuan} and Lien, {Guang Wen} and Lin, {Lain Yu} and Wen, {Li Li} and Liao, {Chien Chang} and Chien, {Kuo Liong} and Sung, {Fung Chang} and Chen, {Pau Chung} and Su, {Ta Chen}",
year = "2013",
month = "10",
day = "5",
doi = "10.1016/j.jhazmat.2013.06.069",
language = "English",
volume = "261",
pages = "372--377",
journal = "Journal of Hazardous Materials",
issn = "0304-3894",
publisher = "Elsevier",

}

TY - JOUR

T1 - Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults

AU - Lin, Chien Yu

AU - Lee, Hui Ling

AU - Chen, Yu Chuan

AU - Lien, Guang Wen

AU - Lin, Lain Yu

AU - Wen, Li Li

AU - Liao, Chien Chang

AU - Chien, Kuo Liong

AU - Sung, Fung Chang

AU - Chen, Pau Chung

AU - Su, Ta Chen

PY - 2013/10/5

Y1 - 2013/10/5

N2 - Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if urinary levels of the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine (AAMA) and the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) are associated. The mean (SD) AAMA and 8-OHdG were 76.54 (76.42). μg/L and 3.48 (2.37). μg/L, respectively. In linear regression analyses, a 1-unit increase in natural log AAMA was significantly associated with an increase in natural log 8-OHdG (μg/g creatinine) (β=0.044, SE=0.019, P=0.020) after controlling for covariates. Subpopulation analyses showed AAMA and 8-OHdG were significantly associated with males, adolescents, non-current smokers, without alcohol consumption, subjects, body mass index ≥24, and homeostasis model assessment of insulin resistance score ≥0.9. In conclusion, higher urinary AAMA concentrations were associated with increased levels of urinary 8-OHdG in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and oxidative stress.

AB - Acrylamide is present in mainstream cigarette smoke and in some foods prepared at high temperatures. Animal studies have shown that acrylamide exposure increases oxidative stress; however, it is not known if this also occurs in humans. We recruited 800 subjects (mean age, 21.3 years, range, 12-30 years) from a population-based sample of Taiwanese adolescents and young adults to determine if urinary levels of the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine (AAMA) and the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) are associated. The mean (SD) AAMA and 8-OHdG were 76.54 (76.42). μg/L and 3.48 (2.37). μg/L, respectively. In linear regression analyses, a 1-unit increase in natural log AAMA was significantly associated with an increase in natural log 8-OHdG (μg/g creatinine) (β=0.044, SE=0.019, P=0.020) after controlling for covariates. Subpopulation analyses showed AAMA and 8-OHdG were significantly associated with males, adolescents, non-current smokers, without alcohol consumption, subjects, body mass index ≥24, and homeostasis model assessment of insulin resistance score ≥0.9. In conclusion, higher urinary AAMA concentrations were associated with increased levels of urinary 8-OHdG in this cohort. Further studies are warranted to determine if there is a causal relationship between acrylamide exposure and oxidative stress.

KW - 8-Hydroxydeoxyguanosine (8-OHdG)

KW - Acrylamide

KW - N-Acetyl-S-(propionamide)-cysteine (AAMA)

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84882760234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882760234&partnerID=8YFLogxK

U2 - 10.1016/j.jhazmat.2013.06.069

DO - 10.1016/j.jhazmat.2013.06.069

M3 - Article

C2 - 23959257

AN - SCOPUS:84882760234

VL - 261

SP - 372

EP - 377

JO - Journal of Hazardous Materials

JF - Journal of Hazardous Materials

SN - 0304-3894

ER -