Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination

Che Ming Hung, Shinn Chih Wu, Chih Ching Yen, Ming Fong Lin, Yi Wen Lai, Yu Tang Tung, Hsiao Ling Chen, Chuan Mu Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalBioMetals
Volume23
Issue number3
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Fingerprint

Lactoferrin
lactoferrin
infectious bursal disease
Immunity
Vaccination
Swine
immunity
vaccination
Communicable Diseases
swine
Antibodies
T-cells
antibodies
Chickens
dosage
T-lymphocytes
Serum
Infectious bursal disease virus
chickens
T-Lymphocytes

Keywords

  • Cytokine
  • Infectious bursal disease (IBD)
  • Lymphocyte proliferation
  • Porcine lactoferrin
  • Serum antibody titer
  • Vaccination

ASJC Scopus subject areas

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

Cite this

Hung, C. M., Wu, S. C., Yen, C. C., Lin, M. F., Lai, Y. W., Tung, Y. T., ... Chen, C. M. (2010). Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination. BioMetals, 23(3), 579-587. https://doi.org/10.1007/s10534-010-9321-5

Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination. / Hung, Che Ming; Wu, Shinn Chih; Yen, Chih Ching; Lin, Ming Fong; Lai, Yi Wen; Tung, Yu Tang; Chen, Hsiao Ling; Chen, Chuan Mu.

In: BioMetals, Vol. 23, No. 3, 06.2010, p. 579-587.

Research output: Contribution to journalArticle

Hung, CM, Wu, SC, Yen, CC, Lin, MF, Lai, YW, Tung, YT, Chen, HL & Chen, CM 2010, 'Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination', BioMetals, vol. 23, no. 3, pp. 579-587. https://doi.org/10.1007/s10534-010-9321-5
Hung, Che Ming ; Wu, Shinn Chih ; Yen, Chih Ching ; Lin, Ming Fong ; Lai, Yi Wen ; Tung, Yu Tang ; Chen, Hsiao Ling ; Chen, Chuan Mu. / Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination. In: BioMetals. 2010 ; Vol. 23, No. 3. pp. 579-587.
@article{0498a764f8f1445fbcd1bc073ba47670,
title = "Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination",
abstract = "In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0{\%} w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.",
keywords = "Cytokine, Infectious bursal disease (IBD), Lymphocyte proliferation, Porcine lactoferrin, Serum antibody titer, Vaccination",
author = "Hung, {Che Ming} and Wu, {Shinn Chih} and Yen, {Chih Ching} and Lin, {Ming Fong} and Lai, {Yi Wen} and Tung, {Yu Tang} and Chen, {Hsiao Ling} and Chen, {Chuan Mu}",
year = "2010",
month = "6",
doi = "10.1007/s10534-010-9321-5",
language = "English",
volume = "23",
pages = "579--587",
journal = "BioMetals",
issn = "0966-0844",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination

AU - Hung, Che Ming

AU - Wu, Shinn Chih

AU - Yen, Chih Ching

AU - Lin, Ming Fong

AU - Lai, Yi Wen

AU - Tung, Yu Tang

AU - Chen, Hsiao Ling

AU - Chen, Chuan Mu

PY - 2010/6

Y1 - 2010/6

N2 - In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.

AB - In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.

KW - Cytokine

KW - Infectious bursal disease (IBD)

KW - Lymphocyte proliferation

KW - Porcine lactoferrin

KW - Serum antibody titer

KW - Vaccination

UR - http://www.scopus.com/inward/record.url?scp=77953233797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953233797&partnerID=8YFLogxK

U2 - 10.1007/s10534-010-9321-5

DO - 10.1007/s10534-010-9321-5

M3 - Article

VL - 23

SP - 579

EP - 587

JO - BioMetals

JF - BioMetals

SN - 0966-0844

IS - 3

ER -