Population-based breast cancer screening with risk-based and universal mammography screening compared with clinical breast examination: A propensity score analysis of 1 429 890 Taiwanese women

Amy Ming Fang Yen, Huei Shian Tsau, Jean Ching Yuan Fann, Sam Li Sheng Chen, Sherry Yueh Hsia Chiu, Yi Chia Lee, Shin Liang Pan, Han Mo Chiu, Wen Horng Kuo, King Jen Chang, Yi Ying Wu, Shu Lin Chuang, Chen Yang Hsu, Dun Cheng Chang, Shing Lang Koong, Chien Yuan Wu, Shu Lih Chia, Mei Ju Chen, Hsiu Hsi Chen, Shu Ti Chiou

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Abstract

Importance: Different screening strategies for breast cancer are available but have not been researched in quantitative detail. Objective: To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). Design: Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009. Asymptomatic women attending outreach screening in the community or undergoing mammography in hospitals were enrolled in the 3 screening programs. Interventions: Risk-based biennial mammography, universal biennial mammography, and annual CBE. Main Outcomes and Measures: Detection rates, stage II+ disease incidence, mortality from breast cancer, and overdiagnosis were compared using a time-dependent Cox proportional hazards regression model. Results: A total of 1 429 890 asymptomaticwomen attending outreach screening in the community or undergoing mammography in hospitalswere enrolled in the 3 screening programs. Detection rates (prevalent screen and subsequent screens per 1000)were the highest for universal biennial mammography (4.86 and 2.98, respectively), followed by risk-based mammography (2.80 and 2.77, respectively), and lowest for annual CBE (0.97 and 0.70, respectively). Universal biennial mammography screening, compared with annual CBE, was associated with a 41% mortality reduction (risk ratio, 0.59; 95%CI, 0.48-0.73) and a 30% reduction of stage II+ breast cancer (RR, 0.70; 95%CI, 0.66-0.74). Risk-based mammography screeningwas associated with an 8%reduction of stage II+ breast cancer (RR, 0.92; 95%CI, 0.86-0.99) butwas not associated with a statistically significant mortality reduction (risk ratio [RR], 0.86; 95%CI, 0.73-1.02). Estimates of overdiagnosiswere no different from CBE for risk-based screening and 13%higher than CBE for universal mammography. Conclusions and Relevance: Compared with population-based screening for breast cancer with annual CBE, universal biennial mammography resulted in a substantial reduction in breast cancer deaths, whereas risk-based biennial mammography resulted in only a modest benefit. Compared with annual CBE, risk-based and universal mammography screening did not result in significant overdiagnosis of breast cancer.

Original languageEnglish
Pages (from-to)915-921
Number of pages7
JournalJAMA oncology
Volume2
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

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Propensity Score
Mammography
Early Detection of Cancer
Breast
Breast Neoplasms
Population
Odds Ratio
Mortality
Incidence
Proportional Hazards Models

ASJC Scopus subject areas

  • Medicine(all)

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Population-based breast cancer screening with risk-based and universal mammography screening compared with clinical breast examination : A propensity score analysis of 1 429 890 Taiwanese women. / Yen, Amy Ming Fang; Tsau, Huei Shian; Fann, Jean Ching Yuan; Chen, Sam Li Sheng; Chiu, Sherry Yueh Hsia; Lee, Yi Chia; Pan, Shin Liang; Chiu, Han Mo; Kuo, Wen Horng; Chang, King Jen; Wu, Yi Ying; Chuang, Shu Lin; Hsu, Chen Yang; Chang, Dun Cheng; Koong, Shing Lang; Wu, Chien Yuan; Chia, Shu Lih; Chen, Mei Ju; Chen, Hsiu Hsi; Chiou, Shu Ti.

In: JAMA oncology, Vol. 2, No. 7, 01.07.2016, p. 915-921.

Research output: Contribution to journalArticle

Yen, AMF, Tsau, HS, Fann, JCY, Chen, SLS, Chiu, SYH, Lee, YC, Pan, SL, Chiu, HM, Kuo, WH, Chang, KJ, Wu, YY, Chuang, SL, Hsu, CY, Chang, DC, Koong, SL, Wu, CY, Chia, SL, Chen, MJ, Chen, HH & Chiou, ST 2016, 'Population-based breast cancer screening with risk-based and universal mammography screening compared with clinical breast examination: A propensity score analysis of 1 429 890 Taiwanese women', JAMA oncology, vol. 2, no. 7, pp. 915-921. https://doi.org/10.1001/jamaoncol.2016.0447
Yen, Amy Ming Fang ; Tsau, Huei Shian ; Fann, Jean Ching Yuan ; Chen, Sam Li Sheng ; Chiu, Sherry Yueh Hsia ; Lee, Yi Chia ; Pan, Shin Liang ; Chiu, Han Mo ; Kuo, Wen Horng ; Chang, King Jen ; Wu, Yi Ying ; Chuang, Shu Lin ; Hsu, Chen Yang ; Chang, Dun Cheng ; Koong, Shing Lang ; Wu, Chien Yuan ; Chia, Shu Lih ; Chen, Mei Ju ; Chen, Hsiu Hsi ; Chiou, Shu Ti. / Population-based breast cancer screening with risk-based and universal mammography screening compared with clinical breast examination : A propensity score analysis of 1 429 890 Taiwanese women. In: JAMA oncology. 2016 ; Vol. 2, No. 7. pp. 915-921.
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abstract = "Importance: Different screening strategies for breast cancer are available but have not been researched in quantitative detail. Objective: To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). Design: Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009. Asymptomatic women attending outreach screening in the community or undergoing mammography in hospitals were enrolled in the 3 screening programs. Interventions: Risk-based biennial mammography, universal biennial mammography, and annual CBE. Main Outcomes and Measures: Detection rates, stage II+ disease incidence, mortality from breast cancer, and overdiagnosis were compared using a time-dependent Cox proportional hazards regression model. Results: A total of 1 429 890 asymptomaticwomen attending outreach screening in the community or undergoing mammography in hospitalswere enrolled in the 3 screening programs. Detection rates (prevalent screen and subsequent screens per 1000)were the highest for universal biennial mammography (4.86 and 2.98, respectively), followed by risk-based mammography (2.80 and 2.77, respectively), and lowest for annual CBE (0.97 and 0.70, respectively). Universal biennial mammography screening, compared with annual CBE, was associated with a 41{\%} mortality reduction (risk ratio, 0.59; 95{\%}CI, 0.48-0.73) and a 30{\%} reduction of stage II+ breast cancer (RR, 0.70; 95{\%}CI, 0.66-0.74). Risk-based mammography screeningwas associated with an 8{\%}reduction of stage II+ breast cancer (RR, 0.92; 95{\%}CI, 0.86-0.99) butwas not associated with a statistically significant mortality reduction (risk ratio [RR], 0.86; 95{\%}CI, 0.73-1.02). Estimates of overdiagnosiswere no different from CBE for risk-based screening and 13{\%}higher than CBE for universal mammography. Conclusions and Relevance: Compared with population-based screening for breast cancer with annual CBE, universal biennial mammography resulted in a substantial reduction in breast cancer deaths, whereas risk-based biennial mammography resulted in only a modest benefit. Compared with annual CBE, risk-based and universal mammography screening did not result in significant overdiagnosis of breast cancer.",
author = "Yen, {Amy Ming Fang} and Tsau, {Huei Shian} and Fann, {Jean Ching Yuan} and Chen, {Sam Li Sheng} and Chiu, {Sherry Yueh Hsia} and Lee, {Yi Chia} and Pan, {Shin Liang} and Chiu, {Han Mo} and Kuo, {Wen Horng} and Chang, {King Jen} and Wu, {Yi Ying} and Chuang, {Shu Lin} and Hsu, {Chen Yang} and Chang, {Dun Cheng} and Koong, {Shing Lang} and Wu, {Chien Yuan} and Chia, {Shu Lih} and Chen, {Mei Ju} and Chen, {Hsiu Hsi} and Chiou, {Shu Ti}",
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TY - JOUR

T1 - Population-based breast cancer screening with risk-based and universal mammography screening compared with clinical breast examination

T2 - A propensity score analysis of 1 429 890 Taiwanese women

AU - Yen, Amy Ming Fang

AU - Tsau, Huei Shian

AU - Fann, Jean Ching Yuan

AU - Chen, Sam Li Sheng

AU - Chiu, Sherry Yueh Hsia

AU - Lee, Yi Chia

AU - Pan, Shin Liang

AU - Chiu, Han Mo

AU - Kuo, Wen Horng

AU - Chang, King Jen

AU - Wu, Yi Ying

AU - Chuang, Shu Lin

AU - Hsu, Chen Yang

AU - Chang, Dun Cheng

AU - Koong, Shing Lang

AU - Wu, Chien Yuan

AU - Chia, Shu Lih

AU - Chen, Mei Ju

AU - Chen, Hsiu Hsi

AU - Chiou, Shu Ti

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Importance: Different screening strategies for breast cancer are available but have not been researched in quantitative detail. Objective: To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). Design: Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009. Asymptomatic women attending outreach screening in the community or undergoing mammography in hospitals were enrolled in the 3 screening programs. Interventions: Risk-based biennial mammography, universal biennial mammography, and annual CBE. Main Outcomes and Measures: Detection rates, stage II+ disease incidence, mortality from breast cancer, and overdiagnosis were compared using a time-dependent Cox proportional hazards regression model. Results: A total of 1 429 890 asymptomaticwomen attending outreach screening in the community or undergoing mammography in hospitalswere enrolled in the 3 screening programs. Detection rates (prevalent screen and subsequent screens per 1000)were the highest for universal biennial mammography (4.86 and 2.98, respectively), followed by risk-based mammography (2.80 and 2.77, respectively), and lowest for annual CBE (0.97 and 0.70, respectively). Universal biennial mammography screening, compared with annual CBE, was associated with a 41% mortality reduction (risk ratio, 0.59; 95%CI, 0.48-0.73) and a 30% reduction of stage II+ breast cancer (RR, 0.70; 95%CI, 0.66-0.74). Risk-based mammography screeningwas associated with an 8%reduction of stage II+ breast cancer (RR, 0.92; 95%CI, 0.86-0.99) butwas not associated with a statistically significant mortality reduction (risk ratio [RR], 0.86; 95%CI, 0.73-1.02). Estimates of overdiagnosiswere no different from CBE for risk-based screening and 13%higher than CBE for universal mammography. Conclusions and Relevance: Compared with population-based screening for breast cancer with annual CBE, universal biennial mammography resulted in a substantial reduction in breast cancer deaths, whereas risk-based biennial mammography resulted in only a modest benefit. Compared with annual CBE, risk-based and universal mammography screening did not result in significant overdiagnosis of breast cancer.

AB - Importance: Different screening strategies for breast cancer are available but have not been researched in quantitative detail. Objective: To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). Design: Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009. Asymptomatic women attending outreach screening in the community or undergoing mammography in hospitals were enrolled in the 3 screening programs. Interventions: Risk-based biennial mammography, universal biennial mammography, and annual CBE. Main Outcomes and Measures: Detection rates, stage II+ disease incidence, mortality from breast cancer, and overdiagnosis were compared using a time-dependent Cox proportional hazards regression model. Results: A total of 1 429 890 asymptomaticwomen attending outreach screening in the community or undergoing mammography in hospitalswere enrolled in the 3 screening programs. Detection rates (prevalent screen and subsequent screens per 1000)were the highest for universal biennial mammography (4.86 and 2.98, respectively), followed by risk-based mammography (2.80 and 2.77, respectively), and lowest for annual CBE (0.97 and 0.70, respectively). Universal biennial mammography screening, compared with annual CBE, was associated with a 41% mortality reduction (risk ratio, 0.59; 95%CI, 0.48-0.73) and a 30% reduction of stage II+ breast cancer (RR, 0.70; 95%CI, 0.66-0.74). Risk-based mammography screeningwas associated with an 8%reduction of stage II+ breast cancer (RR, 0.92; 95%CI, 0.86-0.99) butwas not associated with a statistically significant mortality reduction (risk ratio [RR], 0.86; 95%CI, 0.73-1.02). Estimates of overdiagnosiswere no different from CBE for risk-based screening and 13%higher than CBE for universal mammography. Conclusions and Relevance: Compared with population-based screening for breast cancer with annual CBE, universal biennial mammography resulted in a substantial reduction in breast cancer deaths, whereas risk-based biennial mammography resulted in only a modest benefit. Compared with annual CBE, risk-based and universal mammography screening did not result in significant overdiagnosis of breast cancer.

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